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Showing 1-23 of 23 Resources
  • How Species Coexist

    How Species Coexist

    Lecture

    (27 min 25 sec) Large herbivores in the African savanna coexist by partitioning ecological niches by time, space, and diet.

  • Mapping Genes to Traits in Dogs Using SNPs

    Mapping Genes to Traits in Dogs Using SNPs

    Activity

    In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activity

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Using DNA to Explore Lizard Phylogeny

    Using DNA to Explore Lizard Phylogeny

    Activity

    This activity supports the film The Origin of Species: Lizards in an Evolutionary Tree. Students are guided to sort the lizard species by appearance, then generate a phylogenetic tree using the lizards’ DNA sequences to evaluate whether species that appear similar are closely related to each other.

  • Dog Genomics and Dogs as Model Organisms

    Dog Genomics and Dogs as Model Organisms

    Lecture

    (28 min 54 sec) Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.

  • Creating Phylogenetic Trees from DNA Sequences

    Creating Phylogenetic Trees from DNA Sequences

    Click & Learn

    This Click and Learn explains how DNA sequences can be used to generate such trees, and how to interpret them. English version is ADA accessible.

  • Bacterial ID Virtual Lab App

    Bacterial ID Virtual Lab App

    Apps and eBooks

    Learn about the science and techniques used to identify different types of bacteria based on their DNA sequences

  • Virochip DNA Microarray

    Virochip DNA Microarray

    Click & Learn

    Answer interactive questions to explore the logic of the Virochip microarray design, particularly how evolutionary relationships can be used to detect new viruses.

  • DNA Sequence Assembly

    DNA Sequence Assembly

    Click & Learn

    Learn the principles of how DNA is sequenced and assembled into whole genomes using the Sanger method, shotgun sequencing, or ultra-deep sequencing.

  • Solving SARS and Other Viral Mysteries

    Solving SARS and Other Viral Mysteries

    Lecture

    (58 min 33 sec) The SARS epidemic was successfully halted by a global research effort to identify a new virus.

  • The Virus Hunter's Toolkit

    The Virus Hunter's Toolkit

    Lecture

    (58 min 33 sec) New technologies like the Virochip harness DNA's properties to identify and fight new viruses.

  • Viral Outbreak: The Science of Emerging Disease

    Viral Outbreak: The Science of Emerging Disease

    Lecture

    Watch two leading virus researchers explain how they use both simple and sophisticated technologies to detect and fight infectious agents.

  • Leading-Edge Bioinformatics

    Leading-Edge Bioinformatics

    Clip

    (6 min 36 sec) Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.

  • Running a Virochip Experiment

    Running a Virochip Experiment

    Animation

    (2 min 15 sec) A sample is put on a Virochip microarray, and results are compared to databases of all known viral sequences.

  • Biodiversity and Evolutionary Trees

    Biodiversity and Evolutionary Trees

    Activity

    Construct evolutionary trees by sorting seashells. To accompany the lecture series Exploring Biodiversity: The Search for New Medicines and the Sorting Seashells Click and Learn interactive.

  • Sorting Seashells

    Sorting Seashells

    Click & Learn

    Explore principles of taxonomy by sorting seashells according to their morphological characteristics and constructing an evolutionary tree.

  • DNA Gene Chip Explanation

    DNA Gene Chip Explanation

    Clip

    (1 min 41 sec) Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip.

  • Exclusion Mapping

    Exclusion Mapping

    Animation

    (32 sec) A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.

  • Shotgun sequencing

    Shotgun sequencing

    Animation

    (1 min) In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their sizes can be much larger than the small fragments.

  • Human genome sequencing

    Human genome sequencing

    Animation

    (1 min 49 sec) The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA in question, many fragments represented the same part of the genome. These were aligned by identifying overlapping regions of the sequence, and then they were assembled into the original DNA.

  • How to Analyze DNA Microarray Data

    How to Analyze DNA Microarray Data

    Click & Learn

    DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.

  • Gene Chip Manufacturing

    Gene Chip Manufacturing

    Animation

    (1 min 57 sec) Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.

  • Bacterial Identification Virtual Lab

    Bacterial Identification Virtual Lab

    Virtual Lab

    This virtual lab will familiarize you with the science and techniques used to identify different types of bacteria based on their DNA sequences.

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