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Showing 1-48 of 48 Resources
  • CRISPR-Cas 9 Mechanism & Applications

    CRISPR-Cas 9 Mechanism & Applications

    Click & Learn

    Explore this dynamic interactive to learn the basic principles of how this revolutionary tool works and the many ways in which scientists are using it in their research.

  • Pelvic Evolution in Sticklebacks

    Pelvic Evolution in Sticklebacks

    Data Point

    Scientists used SNP genotyping in populations of freshwater stickleback fish to determine the genetic mutations responsible for the impaired development of pelvises and spines.

  • Central Dogma Card Activity

    Central Dogma Card Activity

    Activity

    In this hands-on activity students review the steps of eukaryotic gene expression and learn how this knowledge can be used to treat genetic disease.

  • Stalking the Genetic Basis of a Trait

    Stalking the Genetic Basis of a Trait

    Activity

    In this activity students analyze data on the expression of the tb1 gene and use it to formulate an explanation as to how a specific difference in the corn version of the gene explains the phenotype of less branching.

  • Teacher Guides

    Teacher Guides

    Collection

    Designed by educators, BioInteractive’s teacher guides will help you select BioInteractive resources aligned to specific topics and standards, including the AP® Biology Curriculum Framework.

  • Stickleback Film with Quiz

    Stickleback Film with Quiz

    Interactive Video

    (15 min 27 sec) Embedded quiz modules test students’ understanding as they watch a short film that explains how stickleback fish let scientists study evolution in action, identify key genes, and peer deep into the evolutionary past.

  • Lactase Film with Quiz

    Lactase Film with Quiz

    Interactive Video

    (14 min 52 sec) Embedded quiz modules test students’ understanding as they watch a short film that explores the evolution of the ability to digest lactose as adults (lactose tolerance) and the genetic changes associated with the trait.

  • Popped Secret Film with Quiz

    Popped Secret Film with Quiz

    Interactive Video

    (17 min 51 sec) Embedded quiz modules test students’ understanding as they watch a short film on the evolutionary origins of corn.

  • Film Guide for Popped Secret: The Mysterious Origin of Corn

    Film Guide for Popped Secret: The Mysterious Origin of Corn

    Film Guide

    The following classroom-ready resources complement the film Popped Secret: The Mysterious Origin of Corn, which tells the story of how geneticists and archaeologists have come together to determine how and where corn was domesticated nearly 9,000 years ago. Also available in Spanish.

  • The Making of the Fittest

    The Making of the Fittest

    Collection

    Each film takes students on an adventure—from the postglacial lakes in southern Alaska to the deserts of the American Southwest, and from the icy Antarctic to the highlands of East Africa, where...

  • How We Get Our Skin Color

    How We Get Our Skin Color

    Animation

    (3 min 32 sec) This engaging animation shows how human skin cells produce the pigment melanin, which gives skin its color. 

  • Popped Secret: The Mysterious Origin of Corn

    Popped Secret: The Mysterious Origin of Corn

    Short Film

    (17 min 51 sec) Where did corn come from? Genetic and archeological data point to what may seem like an unlikely ancestor: a wild Mexican grass called teosinte. Also available in Spanish.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animation

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • Stickleback Evolution Virtual Lab App

    Stickleback Evolution Virtual Lab App

    Apps and eBooks

    App version of the popular virtual lab, introducing you to the science and techniques used to analyze the threespine stickleback fish.

  • Lactose Intolerance: Fact or Fiction

    Lactose Intolerance: Fact or Fiction

    Activity

    Students evaluate and discuss several statements about lactose intolerance and evolution before and after watching the film. Also available in Spanish.

  • Got Lactase? Blood Glucose Data Analysis

    Got Lactase? Blood Glucose Data Analysis

    Activity

    Students interpret the results of two different tests for lactase persistence.

  • Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Activity

    A hands-on activity in which students interpret molecular diagrams and build physical models of eukaryotic gene regulation.

  • Teacher Guide: Gene Regulation

    Teacher Guide: Gene Regulation

    Teacher Guide

    Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.

  • The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

    The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture

    Short Film

    (14 min 52 sec) Follow human geneticist Spencer Wells, Director of the Genographic Project of the National Geographic Society, as he tracks down the genetic changes associated with the ability to digest lactose as adults. Also available in Spanish.

  • Film Guides: Evolving Switches, Evolving Bodies

    Film Guides: Evolving Switches, Evolving Bodies

    Film Guide

    These classroom-ready resources complement the short film Evolving Switches, Evolving Bodies, which tells the story of the dramatic transformation of stickleback fish as they adapted to living in freshwater habitats drastically different from the ocean.

  • Teacher Guide: AP Biology

    Teacher Guide: AP Biology

    Teacher Guide

    This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework. 

  • The Making of the Fittest: Evolving Switches, Evolving Bodies

    The Making of the Fittest: Evolving Switches, Evolving Bodies

    Short Film

    (15 min 27 sec) After the end of the last ice age 10,000 years ago, populations of marine stickleback fish became stranded in freshwater lakes dotted throughout the Northern Hemisphere in places like Alaska and British Columbia. These fish have adapted to a freshwater environment drastically different than the ocean.

  • Regulation of the Lactase Gene

    Regulation of the Lactase Gene

    Click & Learn

    Lactase persistence results from a mutation that changes how transcription factors interact, thereby affecting gene expression.

  • Recent Adaptations in Humans

    Recent Adaptations in Humans

    Click & Learn

    Lactose tolerance, sickle cell anemia, and bitter taste perception are three examples of recently evolved human traits.

  • The Making of the Fittest: Natural Selection and Adaptation

    The Making of the Fittest: Natural Selection and Adaptation

    Short Film

    (10 min 25 sec) The rock pocket mouse is a living example of Darwin’s process of natural selection. Also available in Spanish.

  • Film Guides: Got Lactase? The Co-evolution of Genes and Culture

    Film Guides: Got Lactase? The Co-evolution of Genes and Culture

    Film Guide

    The following classroom-ready resources complement Got Lactase? The Co-evolution of Genes and Culture, which tells the story of the evolution of the ability to digest lactose, a genetic trait that arose in humans within the last 10,000 years in some pastoralist cultures.

  • Genetics of Human Origins and Adaptation

    Genetics of Human Origins and Adaptation

    Lecture

    (58 min 31 sec) Genetic evidence shows that humans evolved in Africa and continue to evolve.

  • Bones, Stones, and Genes: The Origin of Modern Humans

    Bones, Stones, and Genes: The Origin of Modern Humans

    Lecture

    Where and when did humans arise? What distinguishes us from other species? Did our distant ancestors look and behave like us?

  • Regulation of Eukaryotic DNA Transcription

    Regulation of Eukaryotic DNA Transcription

    Animation

    (2 min 5 sec) General transcription factors, activators, and repressors interact to regulate the transcription of eukaryotic DNA into RNA.

  • Bacterial Quorum Sensing

    Bacterial Quorum Sensing

    Click & Learn

    Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animation

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • The molecular cascade in bacterial quorum sensing

    The molecular cascade in bacterial quorum sensing

    Animation

    (3 min 20 sec) Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.

  • Classroom Activities: Gene Switches

    Classroom Activities: Gene Switches

    Activity

    To accompany the lecture series Evolution: Constant Change and Common Threads.

  • Genetic Switches

    Genetic Switches

    Click & Learn

    Learn about how gene switches can control expression of genes in different tissues.

  • Evolution: Constant Change and Common Threads

    Evolution: Constant Change and Common Threads

    Lecture

    How has the amazing diversity of plants and animals evolved? What can fossils, butterflies, and stickleback fish tell us about the deep common ancestry of all living forms?

  • Gene Switch

    Gene Switch

    Animation

    (1 min 15 sec) Regulatory "switches" are found upstream from a gene. Regulatory molecules bind to the switches and recruit RNA polymerase to bind to the gene's promoter region, increasing the transcription of the gene into messenger RNA.

  • Paintbrush Gene

    Paintbrush Gene

    Animation

    (49 sec) In two related Drosophila species, a so-called paintbrush gene is activated to "paint" the pigment on the body. In one species, an extra switch activates the gene, resulting in spotted wings.

  • Pitx1 Expression

    Pitx1 Expression

    Animation

    (55 sec) In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch that normally turns on the Pitx1 gene is either missing or non-functional.

  • PPAR-delta Activation in the Muscle Cell

    PPAR-delta Activation in the Muscle Cell

    Animation

    (1 min 45 sec) The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animation

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • MECP2

    MECP2

    Animation

    (43 sec) This animation shows how the protein MECP2, in conjuction with another protein complex, can act as an "on-off' switch for gene expression.

  • p53

    p53

    Animation

    (26 sec) A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.

  • X Inactivation

    X Inactivation

    Animation

    (55 sec) This animation shows how the random deactivation of one of the X chromosomes in a pair can lead to a mozaicism in the expression genes. 

  • The Meaning of Sex: Genes and Gender

    The Meaning of Sex: Genes and Gender

    Lecture

    Four talks focus on sex determination—the molecular and genetic mechanisms that determine whether an organism will be male, female or a hermaphrodite.

  • Clockwork Genes: Discoveries in Biological Time

    Clockwork Genes: Discoveries in Biological Time

    Lecture

    Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.

  • The Drosophila Molecular Clock Model

    The Drosophila Molecular Clock Model

    Animation

    (7 min 35 sec) Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.

  • The Mammalian Molecular Clock Model

    The Mammalian Molecular Clock Model

    Animation

    (3 min 41 sec) This animation shows the molecular interactions involved in the negative feedback loop responsible for circadian rhythms in mammals.

  • RNA Interference

    RNA Interference

    Click & Learn

    RNA interference is an exciting new research tool for shutting down genes. It could also yield new medical treatments.

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