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  • Patterns in the Distribution of Lactase Persistence

    Patterns in the Distribution of Lactase Persistence

    Activities

    Students explore the geographic distribution of lactase persistence around the world by analyzing real data collected by scientists.

  • DNA Profiling Activity

    DNA Profiling Activity

    Activities

    This multi-part lesson is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world. 

  • CSI Wildlife

    CSI Wildlife

    Click & Learn

    In this interactive, students use DNA profiling, or fingerprinting, to solve two cases of elephant poaching. In the process they will learn about genetic markers, PCR, gel electrophoresis, allele frequencies, and population genetics.

  • Stickleback Film with Quiz

    Stickleback Film with Quiz

    Interactive Videos

    (15 min 27 sec) Embedded quiz modules test students’ understanding as they watch a short film that explains how stickleback fish let scientists study evolution in action, identify key genes, and peer deep into the evolutionary past.

  • Lactase Film with Quiz

    Lactase Film with Quiz

    Interactive Videos

    (14 min 52 sec) Embedded quiz modules test students’ understanding as they watch a short film that explores the evolution of the ability to digest lactose as adults (lactose tolerance) and the genetic changes associated with the trait.

  • The Teosinte Hypothesis

    The Teosinte Hypothesis

    Activities

    In this lesson, students work through the mathematics and concepts behind George Beadle’s claim that teosinte is the wild ancestor of maize. Also available in Spanish.

  • How We Get Our Skin Color

    How We Get Our Skin Color

    Animations

    (3 min 32 sec) This engaging animation shows how human skin cells produce the pigment melanin, which gives skin its color. 

  • Icefish Film with Quiz

    Icefish Film with Quiz

    Interactive Videos

    (13 min 14 sec) Embedded quiz modules test students’ understanding as they watch the short film on the icefish—an example of how genes are reused and recycled.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animations

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • The Eukaryotic Cell Cycle and Cancer

    The Eukaryotic Cell Cycle and Cancer

    Click & Learn

    Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

  • Pedigrees and the Inheritance of Lactose Intolerance

    Pedigrees and the Inheritance of Lactose Intolerance

    Activities

    Students explore the genetic changes associated with lactose tolerance/intolerance and how the trait is inherited in families. Also available in Spanish.

  • Mapping Genes to Traits in Dogs Using SNPs

    Mapping Genes to Traits in Dogs Using SNPs

    Activities

    In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.

  • Cancer Discovery Activities

    Cancer Discovery Activities

    Activities

    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

  • Pulse Chase Primer: The Meselson-Stahl Experiment

    Pulse Chase Primer: The Meselson-Stahl Experiment

    Activities

    This activity can be used in conjunction with the short film The Double Helix. It introduces students to the classic experiment by Matthew Meselson and Franklin Stahl, which revealed that DNA replication follows the semiconservative model.

  • Autism and the Structure and Function of Synapses

    Autism and the Structure and Function of Synapses

    Animations

    (2 min 3 sec) Genes associated with autism affect the structure and function of neuronal synapses.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animations

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animations

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Film Guides: The Double Helix

    Film Guides: The Double Helix

    Film Guides

    The following classroom-ready resources complement The Double Helix. This short film describes the evidence that led James Watson and Francis Crick to the discovery of the double-helical structure of DNA and how the structure immediately revealed how genetic information is stored and inherited.

  • Lactose Intolerance: Fact or Fiction

    Lactose Intolerance: Fact or Fiction

    Activities

    Students evaluate and discuss several statements about lactose intolerance and evolution before and after watching the film. Also available in Spanish.

  • The Double Helix

    The Double Helix

    Short Films

    (16 min 53 sec) The Double Helix is the story of the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. Also available in Spanish.

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