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  • Animated Life: Seeing the Invisible

    Animated Life: Seeing the Invisible

    Animated Short

    (6 min 31 sec) This animated feature celebrates 17th-century citizen-scientist Antonie van Leeuwenhoek, whose discoveries of microbes changed our view of the biological world. Also available in Spanish.

  • The Deep History of a Living Planet

    The Deep History of a Living Planet

    Lecture

    (1 hr 28 min 29 sec) Microbes have been the dominant life form throughout Earth's history. Eukaryotes and animals evolved only after microbes evolved oxygen-generating photosynthesis.

  • Poster: Winogradsky Column—Microbial Evolution in a Bottle

    Poster: Winogradsky Column—Microbial Evolution in a Bottle

    Poster

    A poster from the 2012 Holiday Lectures on Science, Changing Planet: Past, Present, Future. It shows the different organisms and metabolic diversity that results in a miniature model called a Winogradsky column.

  • Winogradsky columns: Microbial ecology in the classroom

    Winogradsky columns: Microbial ecology in the classroom

    Activity

    An activity that recreates zones of microbial activity in a glass column. To accompany the lecture series Changing Planet: Past, Present, Future.

  • Bacterial ID Virtual Lab App

    Bacterial ID Virtual Lab App

    Apps and eBooks

    Learn about the science and techniques used to identify different types of bacteria based on their DNA sequences

  • Q&A on Quorum Sensing

    Q&A on Quorum Sensing

    Lecture

    (12 min 59 sec) In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.

  • Eavesdropping on Tiny Conspiracies

    Eavesdropping on Tiny Conspiracies

    Lecture

    (58 min 29 sec) The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.

  • Shedding Light on an Invisible World

    Shedding Light on an Invisible World

    Lecture

    (58 min 29 sec) Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.

  • Exploring Biodiversity: The Search for New Medicines

    Exploring Biodiversity: The Search for New Medicines

    Lecture

    What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new medicines.

  • Demonstration: Quorum sensing molecules

    Demonstration: Quorum sensing molecules

    Clip

    (50 sec) Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.

  • Demonstration: Glowing bacteria in a flask

    Demonstration: Glowing bacteria in a flask

    Clip

    (52 sec) Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animation

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • The molecular cascade in bacterial quorum sensing

    The molecular cascade in bacterial quorum sensing

    Animation

    (3 min 20 sec) Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.

  • Genetic engineering

    Genetic engineering

    Animation

    (1 min 13 sec) A new gene can be inserted into a loop of bacterial DNA called a plasmid. This is done by cutting the plasmid DNA with a restriction enzyme, which allows a new piece of DNA to be inserted. The ends of the new piece of DNA are stitched together by an enzyme called DNA ligase. The genetically engineered bacteria will now manufacture any protein coded by genes on the newly inserted DNA.

  • Bacterial Identification Virtual Lab

    Bacterial Identification Virtual Lab

    Virtual Lab

    This virtual lab will familiarize you with the science and techniques used to identify different types of bacteria based on their DNA sequences.

  • 2000 and Beyond: Confronting the Microbe Menace

    2000 and Beyond: Confronting the Microbe Menace

    Lecture

    (57 min 36 sec) In four presentations, Donald E. Ganem, MD, and B. Brett Finlay, PhD, discuss the latest advances in understanding how pathogens invade the body and how this knowledge is leading to the development of new therapies. They also explain how new infectious diseases are recognized and how epidemics arise.

  • Size Analogies of Bacteria and Viruses

    Size Analogies of Bacteria and Viruses

    Clip

    (1 min 44 sec) Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.

  • Penicillin acting on bacteria

    Penicillin acting on bacteria

    Clip

    (34 sec) Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.

  • Bacterial Growth

    Bacterial Growth

    Clip

    (54 sec) Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.

  • E. coli Infection Strategy

    E. coli Infection Strategy

    Animation

    (2 min 53 sec) Watch this animation to see the molecular tricks that an infectious strain of Escherichia coli uses to infect your gut.

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