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Showing 1-20 of 24 Resources
  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animation

    (2 min 31 sec) Mutations in the CFTR gene, which encodes a transmembrane ion channel, cause mucus buildup in the airways of patients with cystic fibrosis.

  • HIV Protease Inhibitors

    HIV Protease Inhibitors

    Activity

    This demonstration models how the HIV protease enzyme functions and how its activity is blocked by a class of anti-HIV drugs.

  • HIV Life Cycle Activities

    HIV Life Cycle Activities

    Collection

    A collection of activities and demonstrations focusing on various aspects of the human immunodeficiency virus (HIV) life cycle. They are designed to be completed individually or as part of the series...

  • Viral DNA Integration

    Viral DNA Integration

    Activity

    In this hands-on activity, students model how a double-stranded DNA copy of the HIV genome is integrated into the host cell DNA.

  • HIV Reverse Transcription and AZT

    HIV Reverse Transcription and AZT

    Activity

    Students model how the anti-HIV drug AZT (azidothymidine) interferes with the process of viral replication.

  • HIV Receptors and Co-receptors

    HIV Receptors and Co-receptors

    Activity

    This demonstration models the first step of the HIV life cycle: the binding of HIV envelope proteins to receptors on human helper T cells.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Point

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animation

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Model

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animation

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animation

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • How Do Fibers Form?

    How Do Fibers Form?

    Activity

    A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms. Also available in Spanish.

  • Natural Selection and Evolution of Rock Pocket Mouse Populations

    Natural Selection and Evolution of Rock Pocket Mouse Populations

    Activity

    An activity in which students analyze amino acid data and draw conclusions about the evolution of coat color phenotypes in different rock pocket mouse populations.

  • Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Activity

    An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

  • Structure of Dengue Virus

    Structure of Dengue Virus

    Animation

    (1 min 3 sec) The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.

  • Biodiversity at a Snail's Pace

    Biodiversity at a Snail's Pace

    Lecture

    (58 min 29 sec) Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animation

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

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