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Showing 1-20 of 33 Resources
  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animations

    (2 min 31 sec) Mutations in the CFTR gene, which encodes a transmembrane ion channel, cause mucus buildup in the airways of patients with cystic fibrosis.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animations

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animations

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animations

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • The Double Helix

    The Double Helix

    Short Films

    (16 min 53 sec) The Double Helix is the story of the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. Also available in Spanish.

  • The Day the Mesozoic Died

    The Day the Mesozoic Died

    Short Films

    (33 min 43 sec) The disappearance of the dinosaurs at the end of the Cretaceous period posed one of the greatest, long-standing scientific mysteries. This three-act film tells the story of the extraordinary detective work that solved it. Also available in Spanish.

  • Lactose Digestion in Infants

    Lactose Digestion in Infants

    Animations

    (53 sec) The lactase enzyme is produced in the small intestine of infants. It digests lactose by breaking it into glucose and galactose.

  • Structure of Dengue Virus

    Structure of Dengue Virus

    Animations

    (1 min 3 sec) The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.

  • The Chemical Structure of DNA

    The Chemical Structure of DNA

    Animations

    (2 min 44 sec) DNA's chemical properties can be harnessed for a variety of biotechnology applications.

  • Polymerase chain reaction (PCR)

    Polymerase chain reaction (PCR)

    Animations

    (54 sec) PCR is a standard laboratory technique that allows amplification of specific segments of DNA based on complementarity.

  • The LUX operon controls light production

    The LUX operon controls light production

    Animations

    (2 min 25 sec) A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

  • Signal molecules trigger transcription factors

    Signal molecules trigger transcription factors

    Animations

    (2 min 4 sec) Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.

  • AZT blocks reverse transcriptase

    AZT blocks reverse transcriptase

    Animations

    (1 min 46 sec) HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.

  • PPAR-gamma Activation in the Fat Cell

    PPAR-gamma Activation in the Fat Cell

    Animations

    (2 min 49 sec) The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

  • Watson constructing base pair models

    Watson constructing base pair models

    Clips

    (1 min 42 sec) During the process of trying to elucidate the structure of DNA, Jim Watson made some cardboard models to try to understand how DNA nucleotides are paired. It helped him visualize how hydrogen atoms of paired nucleotides interact with each other to form a symmetrical structure that fits the double helix model.

  • Triplet code

    Triplet code

    Animations

    (1 min 8 sec) Once the structure of DNA was discovered, the next challenge was determining how the sequence of letters coded for the 20 amino acids. In theory, one or two letters can only code for 4 or 16 amino acids, respectively. A scheme using three letters, a triplet code, is the minimum necessary to encode for all the amino acids.

  • DNA transcription (advanced detail)

    DNA transcription (advanced detail)

    Animations

    (1 min 55 sec) The process of copying DNA into messenger RNA (mRNA) is called transcription. Transcription factors assemble at the promoter region of a gene, bringing an RNA polymerase enzyme to form the transcription initiation complex. Activator proteins at the enhancer region of DNA then activate the transcription initiation complex. RNA polymerase unzips a small portion of the DNA and copies one strand into an mRNA molecule. Also available in Spanish.

  • DNA transcription (basic detail)

    DNA transcription (basic detail)

    Animations

    (1 min 55 sec) The first phase of the process of reading DNA information to make proteins starts with a molecule unzipping the DNA. The molecule then copies one of the strands of DNA into a strand of RNA, a close cousin of DNA. This process is called transcription. Also available in Spanish.

  • Sanger method of DNA sequencing

    Sanger method of DNA sequencing

    Animations

    (52 sec) Fred Sanger developed the first technique for sequencing DNA. DNA is replicated in the presence of chemically altered versions of the A, C, G, and T bases. These bases stop the replication process when they are incorporated into the growing strand of DNA, resulting in varying lengths of short DNA. These short DNA strands are ordered by size, and by reading the end letters from the shortest to the longest piece, the whole sequence of the original DNA is revealed.

  • DNA replication (advanced detail)

    DNA replication (advanced detail)

    Animations

    (2 min 20 sec) Both strands of the DNA double helix act as templates for the new DNA strands. Incoming DNA is unraveled by the enzyme helicase, resulting in the 3' strand and the 5' strand. The 3' strands and the 5' strands are replicated by a DNA polymerase enzyme but in different ways. Also available in Spanish.

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