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  • HIV Protease Inhibitors

    HIV Protease Inhibitors

    Activities

    This demonstration models how the HIV protease enzyme functions and how its activity is blocked by a class of anti-HIV drugs.

  • HIV Life Cycle Activities

    HIV Life Cycle Activities

    Collection

    A collection of activities and demonstrations focusing on various aspects of the human immunodeficiency virus (HIV) life cycle. They are designed to be completed individually or as part of the series...

  • Viral DNA Integration

    Viral DNA Integration

    Activities

    In this hands-on activity, students model how a double-stranded DNA copy of the HIV genome is integrated into the host cell DNA.

  • HIV Reverse Transcription and AZT

    HIV Reverse Transcription and AZT

    Activities

    Students model how the anti-HIV drug AZT (azidothymidine) interferes with the process of viral replication.

  • HIV Receptors and Co-receptors

    HIV Receptors and Co-receptors

    Activities

    This demonstration models the first step of the HIV life cycle: the binding of HIV envelope proteins to receptors on human helper T cells.

  • Structure of Dengue Virus

    Structure of Dengue Virus

    Animations

    (1 min 3 sec) The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.

  • AZT blocks reverse transcriptase

    AZT blocks reverse transcriptase

    Animations

    (1 min 46 sec) HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.