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  • HIV Protease Inhibitors

    HIV Protease Inhibitors

    Labs & Demos

    This demonstration models how the HIV protease enzyme functions and how its activity is blocked by a class of anti-HIV drugs.

  • Viral DNA Integration

    Viral DNA Integration

    Labs & Demos

    In this hands-on activity, students model how a double-stranded DNA copy of the HIV genome is integrated into the host cell DNA.

  • HIV Reverse Transcription and AZT

    HIV Reverse Transcription and AZT

    Card Activities

    Students model how the anti-HIV drug AZT (azidothymidine) interferes with the process of viral replication.

  • HIV Receptors and Co-receptors

    HIV Receptors and Co-receptors

    Labs & Demos

    This demonstration models the first step of the HIV life cycle: the binding of HIV envelope proteins to receptors on human helper T cells.

  • Ocean Acidification

    Ocean Acidification

    Labs & Demos

    In this hands-on activity, students simulate the effects of decreasing pH caused by rising levels of atmospheric carbon dioxide.

  • How We Get Our Skin Color Interactive

    How We Get Our Skin Color Interactive

    Interactive Videos

    (3 min 32 sec) This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animations

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Gleevec-Resistant Form of Kinase BCR-ABL

    Gleevec-Resistant Form of Kinase BCR-ABL

    Animations

    (2 min 14 sec) Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

  • Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Gleevec Inhibits Cancer-Causing Kinase BCR-ABL

    Animations

    (3 min 31 sec) The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

  • Film Guides: The Double Helix

    Film Guides: The Double Helix

    Film Activities

    The following classroom-ready resources complement The Double Helix. This short film describes the evidence that led James Watson and Francis Crick to the discovery of the double-helical structure of DNA and how the structure immediately revealed how genetic information is stored and inherited.

  • Lactose Intolerance: Fact or Fiction

    Lactose Intolerance: Fact or Fiction

    Lessons

    In this activity, students evaluate and discuss statements about the evolutionary relationship between milk consumption and lactose tolerance discussed in the short film Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture.

  • The Double Helix

    The Double Helix

    Short Films

    (16 min 53 sec) This film tells the story of the scientists and the evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA.

  • The Day the Mesozoic Died

    The Day the Mesozoic Died

    Short Films

    (33 min 43 sec) This film tells the story of the scientific quest to explain one of the greatest, long-standing scientific mysteries: the sudden disappearance of the dinosaurs at the end of the Cretaceous period.

  • Lactose Digestion in Infants

    Lactose Digestion in Infants

    Animations

    (53 sec) The lactase enzyme is produced in the small intestine of infants. It digests lactose by breaking it into glucose and galactose.

  • Diet and the Evolution of Salivary Amylase

    Diet and the Evolution of Salivary Amylase

    Lessons

    This activity engages students in analyzing authentic scientific data that explore the effects of different diets on the evolution of an enzyme that breaks down starch.

  • How Do Fibers Form?

    How Do Fibers Form?

    Labs & Demos

    In this activity, students construct models of sickle cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape, as described in the short film The Making of the Fittest: Natural Selection in Humans.

  • Natural Selection and Evolution of Rock Pocket Mouse Populations

    Natural Selection and Evolution of Rock Pocket Mouse Populations

    Lessons

    An activity in which students analyze amino acid data and draw conclusions about the evolution of coat color phenotypes in different rock pocket mouse populations.

  • Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Biochemistry and Cell Signaling Pathway of the Mc1r Gene

    Lessons

    An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

  • The Chemical Structure of DNA

    The Chemical Structure of DNA

    Animations

    (2 min 44 sec) DNA's chemical properties can be harnessed for a variety of biotechnology applications.

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