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Showing 1-20 of 69 Resources
  • Cystic Fibrosis Mechanism and Treatment

    Cystic Fibrosis Mechanism and Treatment

    Animations

    (2 min 31 sec) Mutations in the CFTR gene, which encodes a transmembrane ion channel, cause mucus buildup in the airways of patients with cystic fibrosis.

  • EarthViewer

    EarthViewer

    Click & Learn

    Download the accompanying student worksheet under "Downloads." What did Earth look like 250 million years ago? Or 1 billion years ago? Or 4.5 billion years ago? EarthViewer is an interactive tool that allows you to explore the science of Earth's deep history.

  • HIV Protease Inhibitors

    HIV Protease Inhibitors

    Activities

    This demonstration models how the HIV protease enzyme functions and how its activity is blocked by a class of anti-HIV drugs.

  • HIV Life Cycle Activities

    HIV Life Cycle Activities

    Collection

    A collection of activities and demonstrations focusing on various aspects of the human immunodeficiency virus (HIV) life cycle. They are designed to be completed individually or as part of the series...

  • Viral DNA Integration

    Viral DNA Integration

    Activities

    In this hands-on activity, students model how a double-stranded DNA copy of the HIV genome is integrated into the host cell DNA.

  • HIV Reverse Transcription and AZT

    HIV Reverse Transcription and AZT

    Activities

    Students model how the anti-HIV drug AZT (azidothymidine) interferes with the process of viral replication.

  • HIV Receptors and Co-receptors

    HIV Receptors and Co-receptors

    Activities

    This demonstration models the first step of the HIV life cycle: the binding of HIV envelope proteins to receptors on human helper T cells.

  • Ocean Acidification

    Ocean Acidification

    Activities

    In this hands-on activity, students simulate the effects of decreasing pH caused by rising levels of atmospheric carbon dioxide.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Points

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

  • How We Get Our Skin Color Interactive

    How We Get Our Skin Color Interactive

    Interactive Videos

    (3 min 32 sec) This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

  • Chemistry of Life

    Chemistry of Life

    Collection

    Resources related to chemistry, biochemistry, and biological macromolecules such as DNA, RNA, proteins, carbohydrates, and lipids.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animations

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • BCR-ABL: Cancer Protein Structure and Function

    BCR-ABL: Cancer Protein Structure and Function

    Click & Learn

    This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

  • Dasatinib

    Dasatinib

    3D Models

    A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.


  • Imatinib (Gleevec)

    Imatinib (Gleevec)

    3D Models

    A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.

  • Adenosine Triphosphate (ATP)

    Adenosine Triphosphate (ATP)

    3D Models

    A 3D model of adenosine triphosphate, or ATP.

  • Gleevec-resistant BCR-ABL: ABL Kinase Domain

    Gleevec-resistant BCR-ABL: ABL Kinase Domain

    3D Models

    A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

  • BCR-ABL: ABL Kinase Domain

    BCR-ABL: ABL Kinase Domain

    3D Models

    A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

  • Earth Systems Activity

    Earth Systems Activity

    Activities

    This activity guides students through building a conceptual model of how carbon dioxide affects Earth's climate

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Science Talks

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

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