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  • Pelvic Evolution in Sticklebacks

    Pelvic Evolution in Sticklebacks

    Data Points

    Scientists used SNP genotyping in populations of freshwater stickleback fish to determine the genetic mutations responsible for the impaired development of pelvises and spines.

  • Stickleback Film with Quiz

    Stickleback Film with Quiz

    Interactive Videos

    (15 min 27 sec) Embedded quiz modules test students’ understanding as they watch a short film that explains how stickleback fish let scientists study evolution in action, identify key genes, and peer deep into the evolutionary past.

  • The Making of the Fittest

    The Making of the Fittest

    Collection

    Each film takes students on an adventure—from the postglacial lakes in southern Alaska to the deserts of the American Southwest, and from the icy Antarctic to the highlands of East Africa, where...

  • Lactose Intolerance: Fact or Fiction

    Lactose Intolerance: Fact or Fiction

    Activities

    Students evaluate and discuss several statements about lactose intolerance and evolution before and after watching the film. Also available in Spanish.

  • Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish

    Activities

    A hands-on activity in which students interpret molecular diagrams and build physical models of eukaryotic gene regulation.

  • Film Guides: Evolving Switches, Evolving Bodies

    Film Guides: Evolving Switches, Evolving Bodies

    Film Guides

    These classroom-ready resources complement the short film Evolving Switches, Evolving Bodies, which tells the story of the dramatic transformation of stickleback fish as they adapted to living in freshwater habitats drastically different from the ocean.

  • Teacher Guide: AP Biology

    Teacher Guide: AP Biology

    Resource Guides

    This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework. 

  • The Making of the Fittest: Evolving Switches, Evolving Bodies

    The Making of the Fittest: Evolving Switches, Evolving Bodies

    Short Films

    (15 min 27 sec) After the end of the last ice age 10,000 years ago, populations of marine stickleback fish became stranded in freshwater lakes dotted throughout the Northern Hemisphere in places like Alaska and British Columbia. These fish have adapted to a freshwater environment drastically different than the ocean.

  • The Making of the Fittest: Natural Selection and Adaptation

    The Making of the Fittest: Natural Selection and Adaptation

    Short Films

    (10 min 25 sec) The rock pocket mouse is a living example of Darwin’s process of natural selection. Also available in Spanish.

  • Genetic Switches

    Genetic Switches

    Click & Learn

    Learn about how gene switches can control expression of genes in different tissues.

  • Paintbrush Gene

    Paintbrush Gene

    Animations

    (49 sec) In two related Drosophila species, a so-called paintbrush gene is activated to "paint" the pigment on the body. In one species, an extra switch activates the gene, resulting in spotted wings.

  • Pitx1 Expression

    Pitx1 Expression

    Animations

    (55 sec) In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch that normally turns on the Pitx1 gene is either missing or non-functional.

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