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Data PointsResearchers investigated the role of p53 in cell cycle regulation by genetically engineering cell lines with disrupted alleles of the p53 gene. They exposed the cell lines to DNA-damaging radiation and observed how this exposure impacted mitosis.
Data PointsCancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.
Data PointsDr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.
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