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  • Role of p53 in the Cell Cycle

    Role of p53 in the Cell Cycle

    Data Points

    Researchers investigated the role of p53 in cell cycle regulation by genetically engineering a cell line with deleted copies of the p53 gene. They exposed the cell lines to DNA-damaging radiation and observed how this exposure impacted mitosis. Worksheets also available in Spanish.

  • Cell Division and Cancer Risk

    Cell Division and Cancer Risk

    Data Points

    Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.

  • Efficacy of a Treatment for Chronic Myeloid Leukemia

    Efficacy of a Treatment for Chronic Myeloid Leukemia

    Data Points

    Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.