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  • Teacher Guides

    Teacher Guides

    Collection

    Designed by educators, BioInteractive’s teacher guides will help you select BioInteractive resources aligned to specific topics and standards, including the AP® Biology Curriculum Framework.

  • DNA Profiling Activity

    DNA Profiling Activity

    Activity

    This multi-part lesson is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world. 

  • Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Using Genetic Evidence to Identify Ivory Poaching Hotspots

    Data Point

    A team of scientists analyzed the DNA from seized ivory to determine where the ivory from poached elephants came from.

  • CSI Wildlife

    CSI Wildlife

    Click & Learn

    In this interactive, students use DNA profiling, or fingerprinting, to solve two cases of elephant poaching. In the process they will learn about genetic markers, PCR, gel electrophoresis, allele frequencies, and population genetics.

  • Icefish Film with Quiz

    Icefish Film with Quiz

    Interactive Video

    (13 min 14 sec) Embedded quiz modules test students’ understanding as they watch the short film on the icefish—an example of how genes are reused and recycled.

  • Seeing Single Molecules Move

    Seeing Single Molecules Move

    Animation

    (1 min 40 sec) Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

  • Pulse Chase Primer: The Meselson-Stahl Experiment

    Pulse Chase Primer: The Meselson-Stahl Experiment

    Activity

    This activity can be used in conjunction with the short film The Double Helix. It introduces students to the classic experiment by Matthew Meselson and Franklin Stahl, which revealed that DNA replication follows the semiconservative model.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • Using DNA to Explore Lizard Phylogeny

    Using DNA to Explore Lizard Phylogeny

    Activity

    This activity supports the film The Origin of Species: Lizards in an Evolutionary Tree. Students are guided to sort the lizard species by appearance, then generate a phylogenetic tree using the lizards’ DNA sequences to evaluate whether species that appear similar are closely related to each other.

  • Film Guides: The Double Helix

    Film Guides: The Double Helix

    Film Guide

    The following classroom-ready resources complement The Double Helix. This short film describes the evidence that led James Watson and Francis Crick to the discovery of the double-helical structure of DNA and how the structure immediately revealed how genetic information is stored and inherited.

  • The Double Helix

    The Double Helix

    Short Film

    (16 min 53 sec) The Double Helix is the story of the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. Also available in Spanish.

  • Teacher Guide: Biotechnology

    Teacher Guide: Biotechnology

    Teacher Guide

    Topics include: PCR, DNA Sequencing, Genetic Engineering, and Microarray. This guide includes multiple classroom-ready worksheets to accompany HHMI’s virtual labs.

  • The Making of the Fittest: The Birth and Death of Genes

    The Making of the Fittest: The Birth and Death of Genes

    Short Film

    (13 min 10 sec) Scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

  • Film Guides: The Birth and Death of Genes

    Film Guides: The Birth and Death of Genes

    Film Guide

    The following classroom-ready resources complement The Making of the Fittest: The Birth and Death of Genes, which describes how scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

  • DNA Sequence Assembly

    DNA Sequence Assembly

    Click & Learn

    Learn the principles of how DNA is sequenced and assembled into whole genomes using the Sanger method, shotgun sequencing, or ultra-deep sequencing.

  • The Virus Hunter's Toolkit

    The Virus Hunter's Toolkit

    Lecture

    (58 min 33 sec) New technologies like the Virochip harness DNA's properties to identify and fight new viruses.

  • Viral Outbreak: The Science of Emerging Disease

    Viral Outbreak: The Science of Emerging Disease

    Lecture

    Watch two leading virus researchers explain how they use both simple and sophisticated technologies to detect and fight infectious agents.

  • Polymerase chain reaction (PCR)

    Polymerase chain reaction (PCR)

    Animation

    (54 sec) PCR is a standard laboratory technique that allows amplification of specific segments of DNA based on complementarity.

  • Learning from Mice: The Science of Transgenic Technology

    Learning from Mice: The Science of Transgenic Technology

    Clip

    (11 min 8 sec) What do humans, flies, and worms have in common? More than you might think. See how transgenic organisms are engineered, and how they enable researchers to study genetic diseases.

  • Watson constructing base pair models

    Watson constructing base pair models

    Clip

    (1 min 42 sec) During the process of trying to elucidate the structure of DNA, Jim Watson made some cardboard models to try to understand how DNA nucleotides are paired. It helped him visualize how hydrogen atoms of paired nucleotides interact with each other to form a symmetrical structure that fits the double helix model.

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