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  • The Search for a Mutated Gene

    The Search for a Mutated Gene

    Scientists at Work

    (8 min 54 sec) How do you identify the disease-causing mutation in a patient with an inherited disease? This video illustrates the steps involved—testing for genes that are the “usual suspects,” searching for mutations in novel genes, and assessing links between genotype and phenotype.

  • Think Like a Scientist: Natural Selection in an Outbreak

    Think Like a Scientist: Natural Selection in an Outbreak

    Scientists at Work

    (7 min 29 sec) This video brings us to the front lines of the 2013–2015 Ebola outbreak in west Africa and explains how scientists monitored the evolution of the virus by analyzing its genome.

  • Genetically Modified Mosquitoes

    Genetically Modified Mosquitoes

    Scientists at Work

    (8 min 35 sec) Learn the process by which a line of genetically modified mosquitoes was engineered to reduce populations of Aedes aegypti mosquitoes in the wild.

  • How Species Coexist

    How Species Coexist

    Lecture

    (27 min 25 sec) Large herbivores in the African savanna coexist by partitioning ecological niches by time, space, and diet.

  • Ocean Species Respond to Climate Change

    Ocean Species Respond to Climate Change

    Lecture

    (29 min 39 sec) Coral reefs, how they are threatened by climate change, and how to protect them.

  • Rescuing Species

    Rescuing Species

    Lecture

    (29 min 1 sec) How to preserve genetic diversity that is threatened by habitat loss.

  • Holiday Lecture 2004 Update—Jeff Friedman

    Holiday Lecture 2004 Update—Jeff Friedman

    Clip

    (3 min 52 sec) HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.

  • Cancer as a Genetic Disease: Video Highlights

    Cancer as a Genetic Disease: Video Highlights

    Clip

    (8 min 32 sec) In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

  • Dante's Story

    Dante's Story

    Clip

    (6 min 6 sec) Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.

  • DNA Sequence Technology Improves Cancer Treatment

    DNA Sequence Technology Improves Cancer Treatment

    Clip

    (2 min 6 sec) Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

  • The Search for Genetic Mutations that Cause Autism

    The Search for Genetic Mutations that Cause Autism

    Clip

    (2 min 5 sec) Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

  • Meet Dante—A Young Boy with Hemimegalencephaly

    Meet Dante—A Young Boy with Hemimegalencephaly

    Clip

    (2 min 33 sec) Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.

  • Dog Genomics and Dogs as Model Organisms

    Dog Genomics and Dogs as Model Organisms

    Lecture

    (28 min 54 sec) Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.

  • Genomic Medicine, Autism, and Cancer

    Genomic Medicine, Autism, and Cancer

    Lecture

    (37 min 26 sec) A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

  • From Cancer Genomics to Cancer Drugs

    From Cancer Genomics to Cancer Drugs

    Lecture

    (58 min 46 sec) Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

  • Decoding the Autism Puzzle

    Decoding the Autism Puzzle

    Lecture

    (58 min 5 sec) Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.

  • Cancer As a Genetic Disease

    Cancer As a Genetic Disease

    Lecture

    (58 min 33 sec) Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

  • Sizing Up the Brain Gene By Gene

    Sizing Up the Brain Gene By Gene

    Lecture

    (59 min 32 sec) Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

  • Meet Charles Sawyers

    Meet Charles Sawyers

    Clip

    (2 min 27 sec) Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer. 

  • Meet Chris Walsh

    Meet Chris Walsh

    Clip

    (2 min 3 sec) Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

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