Role of p53 in the Cell Cycle

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Summary

Researchers investigated the role of p53 in cell cycle regulation by genetically engineering cell lines with disrupted alleles of the p53 gene. They exposed the cell lines to DNA-damaging radiation and observed how this exposure impacted mitosis.

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Curriculum Connections:

NGSS (2013)
HS-LS1-4
AP Biology (2015)
3.A.2, SP5, SP6
IB Biology (2016)
1.6
Common Core (2010)
ELA.RST.9-12.7, Math.S-ID.3, S-ID.1, MP2, MP5
Vision and Change (2009)
CC5, DP2