Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease

Alzheimer familial genealogy

Summary

A team of scientists built a pedigree of a large extended family in Antioquia, Colombia, that has a high prevalence of early-onset familial Alzheimer’s disease due to a mutation in the PSEN1 gene. Worksheets also available in Spanish.

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Curriculum Connections:

NGSS (2013) LS
HS-LS3-3
AP Biology (2015)
3.A.3, SP5, SP6
AP Environmental Science (2013)
III.B
IB Biology (2016)
3.4
Common Core (2010)
ELA.RST.9-12.7, Math.S-ID.3, S-IC.1, MP2, MP5
Vision and Change (2009)
CC1, CC3, DP2