More About Leptin Neuronal Rewiring
This animation illustrates how providing leptin to an obese mouse rapidly rewires its hypothalamus neurons.
Leptin Neuronal Rewiring Background
When obese mice were given leptin injections, researchers found that the neurons in their hypothalamus were actually being rapidly rewired. Less excitatory inputs and more inhibitory inputs were connected to those neurons responsible for encouraging feeding (called NPY), and the opposite occurred for those neurons responsible for discouraging feeding (called POMC).
From Lecture Four of the 2004 Holiday Lectures Series "The Science of Fat."
Leptin Neuronal Rewiring Teaching Tips
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The 2004 Holiday Lectures Series "The Science of Fat"
Leptin Neuronal Rewiring Credits
Scientific Direction: Jeffrey Friedman, M.D.
Animator: Joe Alexander, New Media and Design, The Rockefeller University