A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms.
Appropriate for: high school biology (all levels), introductory college biology.
This hands-on activity serves as an extension to the Howard Hughes Medical Institute short film The Making of the Fittest: Natural Selection in Humans. Students will construct models of sickle cell hemoglobin inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape.
NGSS (April 2013)
HS-LS1-1, HS-LS3-1, HS-LS3-2, HS-LS4-2, HS-LS4-4, HS-LS1.A, HS-LS3.B, HS-LS4.B, HS-LS4.C
Common Core (2010)
CCSS.ELA-Literacy.RST.9-10.2, CCSS.ELA-Literacy.RST.11-12.4, CCSS.ELA-Literacy.W.9-10.2, CCSS.ELA-Literacy.WHST.9-10.2, CCSS.ELA-Literacy.WHST.11-12.2
AP Biology (2012–13)
3.A.1, 3.C.1, 3.C.2, 4.A.1, 4.B.1
IB Biology (2009)
4.1, 4.3, 5.4, 6.2, 7.5