Scientists are gaining a greater understanding of the genetic and molecular bases of cardiovascular diseases, knowledge that can lead to new tests and therapies. In four lectures, Dr. Christian E. Seidman and Dr. Richard P. Lifton discuss their groundbreaking research. Dr. Seidman explains how heart circulation works and discusses her research in identifying the mutant genes that cause hypertrophic cardiomyopathy, the most common cause of sudden cardiac death in young athletes. Dr. Lifton discusses his work on the genetics of hypertension and other diseases affected by the kidney's ability to regulate salt. The lectures feature an animation on the anatomy of the human heart and questions from the student audience.