The following classroom-ready resources complement The Making of the Fittest: Natural Selection in Humans, which describes the connection between malaria and sickle cell anemia—one of the best-understood examples of natural selection in humans. Also available in Spanish.
- NGSS (2013) LS
- LS1.A, LS2.A, LS2.C, LS3.A, LS3.B, LS4.B, LS4.B, LS4.C
- AP Biology (2012-2013)
- 1.A.1, 1.A.2, 3.C.1, 3.C.2, 4.C.1
- IB Biology (2009)
- 4.1, 4.3, 5.4, D.2
721ActivitiesMendelian Genetics, Probability, Pedigree, and Chi-Square StatisticsA lesson that requires students to work through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria. These questions will probe students' understanding of Mendelian genetics, probability, pedigree analysis, and chi-square statistics. Also available in Spanish.
27ActivitiesHow Do Fibers Form?A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms. Also available in Spanish.