A sample is put on a Virochip microarray, and results are compared to databases of all known viral sequences.
The geometric structures of viruses are beautiful and can be used, along with genomic information, to identify them.
PCR is a standard laboratory technique that allows amplification of specific segments of DNA based on complementarity.
DNA's chemical properties can be harnessed for a variety of biotechnology applications.
Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for translating proteins.
Since the 1960s dengue fever has spread to many countries and total case numbers have exploded.
The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.
Infection begins when the dengue virus uses receptors on an immune cell's surface to gain entry and release its genome.
The fight against dengue fever, and the mosquitoes that carry the virus, is being carried out by "brigadistas" in Managua's neighborhoods. Spanish with English subtitles.
Charles Runckel, a graduate student in the DeRisi lab, uses the Virochip to examine the mystery of bee colony collapse disorder.
“The Assemblers” (Peter Skewes-Cox and Dr. Graham Ruby) sing about DNA and proteins.
Several members of a Nicaraguan research team describe the impact of technology transfer.
An interview with Dr. DeRisi.
An interview with Dr. Harris.
In the effort to eradicate dengue and mosquitoes, neighborhood leaders work with local conditions.
Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.
Poor management of drainage, drinking water, and wastewater, makes excellent mosquito habitat.
To prevent mosquitoes from spreading diseases, it's essential to understand their life cycle.
Reggaeton, a popular Latin music form, rallies against dengue.
Through the efforts of the Sustainable Sciences Institute, Nicaragua’s research capacity and disease-monitoring tools have improved dramatically.
Many infectious diseases affect people in Nicaragua, and identifying the pathogens is surprisingly difficult.
Katherine Sorber, a graduate student in the DeRisi lab, describes her research on malaria.
The Nicaraguan grassroots program teaches mosquito control methods to curb dengue fever epidemics.
Ben Vincent describes his summer work collecting mosquitoes for Dr. Marm Kilpatrick's research on the ecology and epidemiology of the West Nile virus.
Kate Williams, a graduate student in the Harris lab, describes her epidemiological research linking antibodies and severe dengue in Nicaragua.
Nathan Yozwiak, a graduate student in the Harris/DeRisi labs, discusses working in Nicaragua to discover a new virus infecting children.
Watch two leading virus researchers explain how they use both simple and sophisticated technologies to detect and fight infectious agents.
Learn about research aimed at thwarting dengue fever in the lab and in communities.
New technologies like the Virochip harness DNA's properties to identify and fight new viruses.
Understanding the immune response is essential to developing safe vaccines for dengue and other diseases.
The SARS epidemic was successfully halted by a global research effort to identify a new virus.
This discussion from the 2010 Holiday Lectures on Science explores the ethics of genetically-modified organisms and other topics.
West Nile virus infects mosquitoes, birds, and people—with very different consequences.
Learn about the nature of vector-borne diseases, and the life cycle of the dengue vector mosquito.
Learn the principles of how DNA is sequenced and assembled into whole genomes using the Sanger method, shotgun sequencing, or ultra-deep sequencing.
Answer interactive questions to explore the logic of the Virochip microarray design, particularly how evolutionary relationships can be used to detect new viruses.
To accompany the lecture series Viral Outbreak: The Science of Emerging Disease.
A text transcript of the 2010 Holiday Lectures on Science, Viral Outbreak: The Science of Emerging Disease.
A chapter list to accompany the DVD.
The poster from the 2010 Holiday Lectures, Viral Outbreak: The Science of Emerging Disease, illustrating the size, geometry, and different classifications of viruses.
In this activity, students rear mosquitoes in chambers and test variables that might affect the life cycle of the mosquito.
Are you a vector or a host? Play the West Nile virus game to learn how the virus spreads and how the outcome changes depending on who gets infected.
A 3D model of dengue virus.
A 3D model of nodamura virus.
A 3D model of rhinovirus, an RNA genome virus that is the main cause of the common cold in humans.