To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia.
Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.