Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs.
Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.
Sickle cell anemia is a genetic disease that affects hemoglobin.
When a malaria-carrying mosquito bites a human host, the malaria parasite enters the bloodstream, multiplies in the liver cells, and is then released back into the bloodstream, where it infects and destroys red blood cells.
A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.
Why has it been so hard to develop a vaccine against HIV? How are new medicines revolutionizing AIDS treatment? Can AIDS be cured?
The genesis of AIDS, identifying HIV as the virus that causes AIDS, and the modern global epidemic.
The HIV life cycle, and how the virus destroys the immune system's ability to respond to infection.
Treating HIV infection with antiretroviral therapy, and HIV's ability to develop drug resistance.
The search for an effective HIV vaccine, and advances in genomics that may lead to a breakthrough.
Three HIV-positive individuals share their personal experiences about living with HIV.
Dr. Donald Ganem describes how epidemiologists, physicians, and microbiologists work together to identify and study pathogens.
Dr. Brett Finlay explains why bacterial diseases continue to be a major health problem worldwide, causing a third of the world's deaths every year.
Dr. Finlay showcases three types of bacteria to illustrate how molecular biology is allowing researchers to probe the molecular workings of bacterial infections.
Dr. Ganem analyses the complex causes of epidemics—how changes in the environment and in human social behavior can give rise to new infectious diseases.
The lecturers, joined by Dr. Kay Jamison of the Johns Hopkins University School of Medicine and Dr. Gerald Fischbach of the Simons Foundation, answer questions concerning autism, manic depression, and other mental illnesses.
As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge...
Although there are numerous kinds of cancer, all stem from alterations that allow cell division to outstrip cell demise.
The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.
Mutations in key genes can lay waste to the nervous system. By studying large families predisposed to developing these genetic disorders, scientists can identify the responsible altered gene.
Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.
In four lectures, Richard P. Lifton, MD, PhD, and Christine E. Seidman, MD, discuss their groundbreaking work in using genetic and molecular approaches to understand cardiovascular diseases.
The heart acts as a dual pump, sending oxygen-depleted blood to the lungs to be reinvigorated and pumping oxygen-rich blood to vital organs throughout the body.
The discovery of DNA as the basis of heredity led to an explosive growth of knowledge about the human genome and allowed the identification of genes that predispose people to different diseases.
Although heart disease typically occurs after middle age, seemingly fit and healthy young individuals can die suddenly from unrecognized heart disease.