Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.
Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.
Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.
Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses.
Long-term memory requires the activation of CREB, turning on specific genes that support new synaptic growth.
Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.
Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.
A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.
A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.
Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.
A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.
Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.
What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
How a nerve cell gets its identity, sends axons, and makes connections with other cells.
Understanding the neural circuits in the spinal cord that control movement.
The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice.
In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.
Dr. Hudspeth will begin by discussing how simple organisms—such as bacteria—have the capacity to detect and react to a stimulus.
Dr. Nathans will discuss how the visual process involves the detection of light by photo-receptors in the retina.
Dr. Hudspeth will explain the basis for the ear’s remarkable ability to detect sound through the hair cell, the sensory receptor found in the inner ear.
Dr. Nathans will complete the lecture series by clarifying what is known about the brain’s ability to process and integrate various elements of the visual system, such as color, motion, and depth.
The poster from the 2008 Holiday Lectures on Science, Making Your Mind: Molecules, Motion, and Memory. It illustrates the structure and function of a neuron, including how it transmits electrical and chemical signals.
(This poster is designed to printed at a maximum size of 29.5...
Genes associated with autism affect the structure and function of neuronal synapses.