Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.
Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.
A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.
Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.
Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.
What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new...
Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.
Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.
Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.
The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.
In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.
Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.
Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.