This animation illustrates how a small molecule binds to a protein. As a result of the binding, the protein alters its shape and becomes inactivated.
A molecular menagerie of small molecules is displayed, with two particular molecules singled out for attention: rapamycin and furrowstatin, which are discussed in the remainder of Dr. Schreiber's lectures on chemical genetics.
Microarray technology is useful for screening many small molecules at once. Automated devices have made it possible for thousands of different small molecules to be printed as an array of spots on a glass slide. A single type of protein which has been tagged with a fluorescent marker can then be...
Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressive properties. It also allows two proteins which do not normally interact to bind together in the cell, which causes problems in the nutrient-sensing pathway.
Myosin II is one of the molecules involved in furrow formation in dividing cells. This animation shows how the molecule operates, and how furrowstatin blocks the mechanism and halts division of a cell.
After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.
One technique for discovering small molecules of biological relevance is to expose cultured cells to a variety of small molecules and look for changes in the cells' appearance, behavior or other measurable qualities.
The hypothetical relationship of chemical space and biological space is plotted on a three-dimensional graph, giving a glimpse of the future direction of research at the intersections of various disciplines.
In diversity-oriented synthesis, many combinations of chemical building blocks undergo relatively few reaction steps to form a vast variety of different molecules. In this example, 45 x 45 x 45 combinations yield more than 88,000 novel molecules.
The small molecule 'furrowstatin' exemplifies the power of using small molecules to investigate life's processes. When applied to dividing cells, the furrowstatin halts cell division.
Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.
Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemisty, and biology are all used in DOS...
An interview with Manolis Kamvysselis, a scientist in Dr. Lander's lab.
An interview with Angela Koehler, a scientist in Dr. Schreiber's lab.
How a microarraying robot delivers hundreds of small molecules to a series of slides.
An interview with Dr. Schreiber.
In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.
To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.
Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.
Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?
A wide-ranging 45-minute discussion between Dr. Eric Lander, Dr. Stuart Schreiber, and four Washington DC-area high school teachers.
How both gene chips and microarray slides are created.
Small molecules are chemicals that can interact with proteins to affect their functions. Learn about the structure and biological functions of various small molecules like sugar and caffeine.
DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.
All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.