Title Biointeractive Type Biointeractive Topics Post date Summary
Rett Syndrome Mouse /biointeractive/rett-syndrome-mouse Clip Neuroscience, Behavior Saturday, February 1, 2003 - 2:08pm

Dr. Zoghbi shows how a mouse that has been given the gene responsible for Rett syndrome exhibits some of the same neurological symptoms as human Rett patients.

Evolution of the Y Chromosome /biointeractive/evolution-y-chromosome Animation Mechanisms of evolution, Mendelian inheritance Thursday, February 1, 2001 - 2:15pm

How did the human Y chromosome become so small relative to its X counterpart? This animation depicts the 300-million-year odyssey of the sex chromosomes that began when the proto X and Y were an identical pair.

The Y Chromosome /biointeractive/y-chromosome Animation Mechanisms of evolution, DNA Thursday, February 1, 2001 - 2:25pm

The Y chromosome has been likened to a hall of mirrors because its sequence contains many sections that appear to be palindromes. These palindromes provide a clue to some interesting events that may have occurred during the course of the chromosome's evolution.

X Inactivation /biointeractive/x-inactivation Animation Gene regulation, Developmental biology, Cell growth and division Tuesday, February 4, 2003 - 2:40pm

This animation shows how the random deactivation of one of the X chromosomes in a pair can lead to a mozaicism in the expression genes. 

Zebrafish Heart Regeneration /biointeractive/zebrafish-heart-regeneration Animation Circulation, Cell growth and division, Cell signaling Saturday, February 4, 2006 - 2:49pm

The zebrafish heart is similar to the human heart in many respects. But unlike the human heart, the fish heart closes wounds rapidly and then regenerates to nearly full function. Fibroblast growth factor (FGF) is an important molecule in the regeneration process.

Wing Morph /biointeractive/wing-morph Animation Mechanisms of evolution, Gene regulation Friday, February 4, 2005 - 2:55pm

This "morph" animation demonstrates how the expression of a particular toolkit gene in a butterfly larva corresponds to the location of the wing eyespots in an adult butterfly.

Running a Virochip Experiment /biointeractive/running-virochip-experiment Animation Bioinformatics, Infectious disease, Biotechnology Thursday, February 4, 2010 - 3:16pm

A sample is put on a Virochip microarray, and results are compared to databases of all known viral sequences.

Viral Lifecycle /biointeractive/viral-lifecycle Animation Virus, Infectious disease Thursday, February 4, 1999 - 3:52pm

Delivering a single virus to a cell allows the virus to infect the cell, replicate, and give rise to many progeny viruses. These viruses can then infect many neighboring cells. Also available in Spanish.

Viral Geometry and Structural Diversity /biointeractive/viral-geometry-and-structural-diversity Animation Virus, Infectious disease Thursday, February 4, 2010 - 3:55pm

The geometric structures of viruses are beautiful and can be used, along with genomic information, to identify them.

VEGF /biointeractive/vegf Animation Cancer, Cell signaling Tuesday, February 4, 2003 - 3:59pm

This animation shows how a growing tumor can recruit nearby blood vessels in order to gain a supply of blood.

Using Small Molecules to Modulate a Protein /biointeractive/using-small-molecules-modulate-protein Animation Chemistry, Proteins Monday, February 4, 2002 - 4:04pm

This animation illustrates how a small molecule binds to a protein. As a result of the binding, the protein alters its shape and becomes inactivated.

Using p53 to Fight Cancer /biointeractive/using-p53-fight-cancer Animation Virus, Cancer, Biotechnology Tuesday, February 4, 2003 - 4:07pm

This animation demonstrates how cancerous cells could be destroyed using a modified virus.

U.S. AIDS epidemic /biointeractive/us-aids-epidemic Animation Virus, Infectious disease, Science and society Sunday, February 4, 2007 - 4:10pm

A visual representation of the U.S. AIDS epidemic from 1981 to 1997. Each dot represents 30 cases.

Tri Nucleotide Repeat /biointeractive/tri-nucleotide-repeat Animation DNA, Genetic basis of disease Tuesday, February 4, 2003 - 4:14pm

Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs. 

Cloning an Army of T Cells for Immune Defense /biointeractive/cloning-army-t-cells-immune-defense Animation Immunology, Cell signaling Monday, February 4, 2013 - 4:19pm

View the animation to see how one type of immune cell—the helper T cell—interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.

Fossil Record of Stickleback Evolution /biointeractive/fossil-record-stickleback-evolution Clip Mechanisms of evolution, Paleobiology, Skin, muscles, and bones Friday, February 4, 2005 - 4:24pm

A quarry site in Nevada carries the evolutionary history of a population of stickleback fish that resided there when it was a freshwater lake.

Stickleback CT Scan /biointeractive/stickleback-ct-scan Animation Skin, muscles, and bones Friday, February 4, 2005 - 4:34pm

This animation shows a rotating 3-D image of a stickleback skeleton. The pelvic region, including the pelvic spines, is highlighted in red. Armored plating covers the flanks of the fish. The three prominent dorsal spines give the fish its name.

Diversity of Small Molecules /biointeractive/diversity-small-molecules Animation Chemistry, Biotechnology Monday, February 4, 2002 - 4:47pm

A molecular menagerie of small molecules is displayed, with two particular molecules singled out for attention: rapamycin and furrowstatin, which are discussed in the remainder of Dr. Schreiber's lectures on chemical genetics.

Small-Molecule Microarrays /biointeractive/small-molecule-microarrays Animation Chemistry, Biotechnology Monday, February 4, 2002 - 4:50pm

Microarray technology is useful for screening many small molecules at once. Automated devices have made it possible for thousands of different small molecules to be printed as an array of spots on a glass slide. A single type of protein which has been tagged with a fluorescent marker can then be washed across the array. Any small molecule that binds to the protein can be detected by scanning for spots that are fluorescent.

Signal molecules trigger transcription factors /biointeractive/signal-molecules-trigger-transcription-factors Animation Biochemistry, Developmental biology, Neuroscience, Cell signaling Monday, February 4, 2008 - 4:53pm

Varying concentrations of a signaling molecule activate different transcription factors and determine cell fate.

Somatic Cell Nuclear Transfer Animation /biointeractive/somatic-cell-nuclear-transfer-animation Animation Developmental biology, Stem cells, Biotechnology Saturday, February 4, 2006 - 4:56pm

Somatic cell nuclear transfer (SCNT) is a technique for cloning. The nucleus is removed from a healthy egg. This egg becomes the host for a nucleus that is transplanted from another cell, such as a skin cell. The resulting embryo can be used to generate embryonic stem cells with a genetic match to the nucleus donor (therapeutic cloning), or can be implanted into a surrogate mother to create a cloned individual, such as Dolly the sheep (reproductive cloning).

The Human Suprachiasmatic Nucleus /biointeractive/human-suprachiasmatic-nucleus Animation Neuroscience, Behavior Friday, February 4, 2000 - 5:02pm

In mammals, the controlling clock component that generates a 24-hour rhythm is the suprachiasmatic nucleus (SCN), located in a part of the brain called the hypothalamus. The SCN produces a signal that can keep the rest of the body on an approximately 24-hour schedule. This animation illustrates the location of the SCN in the human brain.

SCA1 Pedigree /biointeractive/sca1-pedigree Animation Mendelian inheritance, Neuroscience Tuesday, February 4, 2003 - 5:11pm

Illustrates how studying one family's pedigree can reveal an entire history of passing on a genetic disorder such as SCA1.

Intracellular Infection by Salmonella /biointeractive/intracellular-infection-salmonella Animation Bacteria, Infectious disease Thursday, February 4, 1999 - 5:13pm

In this animation, you can see how one S. typhimurium invades an epithelial cell of the intestinal tract, survives the intracellular defense mechanisms of the host cell, and multiplies.

RNA Folding /biointeractive/rna-folding Animation Nucleic acids, RNA Saturday, February 4, 1995 - 5:17pm

Since RNA is single-stranded, it can fold upon itself and form structures that are protein-like in both appearance and functionality.

AZT blocks reverse transcriptase /biointeractive/azt-blocks-reverse-transcriptase Animation Biochemistry, Virus, RNA, Infectious disease Sunday, February 4, 2007 - 5:20pm

HIV's reverse transcriptase mistakes AZT for thymidine. Once incorporated, AZT stops reverse transcription.

Repellant ephrin signals guide limb innervations /biointeractive/repellant-ephrin-signals-guide-limb-innervations Animation Skin, muscles, and bones, Developmental biology, Neuroscience, Cell signaling Monday, February 4, 2008 - 5:24pm

The growth cone of a neuron avoids repellant molecules and navigates to innervate the appropriate muscle.

Recombination of Viral Genome /biointeractive/recombination-viral-genome Animation Virus, RNA, Infectious disease Thursday, February 4, 1999 - 5:27pm

When two different strains of influenza infect a single cell, their genetic material can mix freely, resulting in a new third strain of influenza.

Rapamycin /biointeractive/rapamycin Animation Chemistry, Proteins Monday, February 4, 2002 - 5:34pm

Rapamycin is a small molecule originally isolated from nature. It has antibiotic and immunosuppressive properties. It also allows two proteins which do not normally interact to bind together in the cell, which causes problems in the nutrient-sensing pathway.

Meiosis /biointeractive/meiosis Animation DNA, Developmental biology, Cell growth and division Sunday, February 4, 2001 - 5:37pm

Meiosis, the form of cell division unique to egg and sperm production, sets the stage for sex determination by creating sperm that carry either an X or a Y sex chromosome. But what is it about the X or Y that determines sex? Also available in Spanish.

Mismatch Repair /biointeractive/mismatch-repair Animation Nucleic acids, DNA Tuesday, February 4, 2003 - 5:41pm

This animation illustrates how mistakes made during DNA replication are repaired.

The molecular cascade in bacterial quorum sensing /biointeractive/molecular-cascade-bacterial-quorum-sensing Animation Bacteria, Gene regulation, Cell signaling Wednesday, February 4, 2009 - 5:44pm

Quorum sensing regulates gene expression by a protein phosphorylation cascade that controls transcription.

The Proteasome /biointeractive/proteasome Animation Proteins, Cell structure Tuesday, February 4, 2003 - 5:48pm

A 3D animation showing how proteins in the cell are tagged for disposal and degraded by the proteasome.

Protease inhibitors /biointeractive/protease-inhibitors Animation Gene expression, Immunology, Infectious disease Sunday, February 4, 2007 - 5:54pm

Protease inhibitors prevent maturation of viral proteins inside HIV particles.

Prialt blocks pain signaling in mice /biointeractive/prialt-blocks-pain-signaling-mice Animation Phylogeny and classification, Skin, muscles, and bones, Neuroscience, Cell signaling Wednesday, February 4, 2009 - 5:57pm

Prialt does not block the mammalian motor synapse, but blocks the pain pathway in the spinal cord.

Prialt blocks motor synapse in fish /biointeractive/prialt-blocks-motor-synapse-fish Animation Skin, muscles, and bones, Neuroscience, Cell signaling Wednesday, February 4, 2009 - 6:00pm

Prialt, a drug derived from cone snail venom, paralyzes fish by blocking calcium channels at a motor synapse.

PPAR-gamma Activation in the Fat Cell /biointeractive/ppar-gamma-activation-fat-cell Animation Proteins, Gene regulation, Nutrition, Cell signaling Wednesday, February 4, 2004 - 6:04pm

The PPAR-gamma receptor activates certain genes in a fat cell, resulting in the storage of fat and changes in hormone levels.

PPAR-delta Activation in the Muscle Cell /biointeractive/ppar-delta-activation-muscle-cell Animation Proteins, Gene regulation, Nutrition Wednesday, February 4, 2004 - 6:08pm

The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat.

Pocket Mouse and Predation /biointeractive/pocket-mouse-and-predation Animation Mechanisms of evolution, Natural selection Friday, February 4, 2005 - 6:14pm

The rock pocket mouse is found in two color variants, or morphs: light and dark. In different environments, their visibility to predators such as owls varies. The dark morph is more vulnerable on light sandy desert, and the light morph on dark lava rock.

Pocket Mouse Evolution /biointeractive/pocket-mouse-evolution Animation Mechanisms of evolution, Natural selection, Evolution of populations Friday, February 4, 2005 - 6:16pm

This simulation shows the spread of a favorable mutation through a population of pocket mice. Even a small selective advantage can lead to a rapid evolution of the population.

Pitx1 Expression /biointeractive/pitx1-expression Animation Mechanisms of evolution, Gene regulation, Developmental biology Friday, February 4, 2005 - 6:20pm

In the stickleback fish, pelvic-fin reduction resulted from changes in the regulatory switch elements of the Pitx1 gene. In the marine ancestor, the Pitx1 gene is activated in the pelvic-fin region during development to generate the fin. In the pelvic-reduced stickleback, the regulatory switch that normally turns on the Pitx1 gene is either missing or non-functional.

Polymerase chain reaction (PCR) /biointeractive/polymerase-chain-reaction-pcr Animation Biochemistry, DNA, Biotechnology Thursday, February 4, 2010 - 6:24pm

PCR is a standard laboratory technique that allows amplification of specific segments of DNA based on complementarity.

Paintbrush Gene /biointeractive/paintbrush-gene Animation Mechanisms of evolution, Gene regulation Friday, February 4, 2005 - 6:27pm

In two related Drosophila species, a so-called paintbrush gene is activated to "paint" the pigment on the body. In one species, an extra switch activates the gene, resulting in spotted wings.

p53 /biointeractive/p53 Animation Gene regulation, Cancer Tuesday, February 4, 2003 - 6:30pm

A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA.

Newt Limb Regeneration /biointeractive/newt-limb-regeneration Animation Cell growth and division, Stem cells Saturday, February 4, 2006 - 6:33pm

Urodele amphibians—newts and salamanders—are able to regenerate fully functional limbs in response to amputation. Cells in and near the limb stump dedifferentiate to form a mass of stemlike cells that can produce all the specialized tissues of the limb, such as muscle, nerves, and blood vessels.

Neurons in parietal cortex are active during straddling /biointeractive/neurons-parietal-cortex-are-active-during-straddling Animation Neuroscience, Behavior Monday, February 4, 2008 - 6:38pm

Neurons in the cortical area 5 are active when a cat is straddling an obstacle.

Myosin II Mechanism /biointeractive/myosin-ii-mechanism Animation Proteins, Biochemistry, Cell growth and division Monday, February 4, 2002 - 6:43pm

Myosin II is one of the molecules involved in furrow formation in dividing cells. This animation shows how the molecule operates, and how furrowstatin blocks the mechanism and halts division of a cell.

Motor cabal toxins block motor neuron synapses /biointeractive/motor-cabal-toxins-block-motor-neuron-synapses Animation Skin, muscles, and bones, Neuroscience, Biotechnology Wednesday, February 4, 2009 - 6:46pm

Multiple cone snail toxins attack different molecules of the nervous system and cause paralysis.

Molecular Screening /biointeractive/molecular-screening Animation Genomics, Biotechnology Monday, February 4, 2002 - 6:57pm

After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be "screened." Conceptually, screening is like using proteins as a custom filter to catch potentially useful small molecules.

Molecular Mechanism of Synaptic Function /biointeractive/molecular-mechanism-synaptic-function Animation Neuroscience, Cell signaling Monday, February 4, 2008 - 7:00pm

Electrical and chemical signals are used by neurons to communicate with one another at contact points called synapses. Also available in Spanish.

MIX-1 /biointeractive/mix-1 Animation Gene regulation, Developmental biology, Cell growth and division Sunday, February 4, 2001 - 7:04pm

This animation shows how MIX-1 facilitates both chromosome condensation and dosage compensation.

MECP2 /biointeractive/mecp2 Animation DNA, Gene regulation Wednesday, February 5, 2003 - 10:17am

This animation shows how the protein MECP2, in conjuction with another protein complex, can act as an "on-off' switch for gene expression.

The Mammalian Molecular Clock Model /biointeractive/mammalian-molecular-clock-model Animation Gene regulation, Behavior Saturday, February 5, 2000 - 10:21am

This animation shows the molecular interactions involved in the negative feedback loop responsible for circadian rhythms in mammals.

Measuring Circadian Activity in Drosophila /biointeractive/measuring-circadian-activity-drosophila Animation Behavior, Scientific methodology Saturday, February 5, 2000 - 10:48am

This animation series shows four experiments that compare the activity patterns of a wild-type fly keeping a normal schedule with those of a mutant fly apparently following a 19-hour internal clock.

Angiogenesis /biointeractive/angiogenesis Animation Cell growth and division, Cell signaling, Cancer Wednesday, February 5, 2003 - 10:51am

A cancer tumor forms in a bed of healthy cells. The animation goes on to show how the tumor recruits blood vessels and how metastasis occurs. Also available in Spanish.

Antigen presentation and CTL /biointeractive/antigen-presentation-and-ctl Animation Immunology, Infectious disease, Cell signaling Monday, February 5, 2007 - 10:56am

How a cell infected by a virus signals cytotoxic T lymphocytes to kill the cell before the virus replicates and spreads.

Molecular activity in Aplysia long-term memory /biointeractive/molecular-activity-aplysia-long-term-memory Animation Neuroscience, Cell signaling Tuesday, February 5, 2008 - 10:59am

Long-term memory requires the activation of CREB, turning on specific genes that support new synaptic growth.

Molecular activity in Aplysia short-term memory /biointeractive/molecular-activity-aplysia-short-term-memory Animation Neuroscience, Cell signaling Tuesday, February 5, 2008 - 11:04am

Short-term memory relies on serotonin activating a protein kinase to modify existing synaptic strength.

Body Mass Index (BMI) /biointeractive/body-mass-index-bmi Animation Nutrition, Science and society Thursday, February 5, 2004 - 11:11am

Comparison of the change in BMI for a given height and varying weights.

Cellular Screening /biointeractive/cellular-screening Animation Biotechnology Tuesday, February 5, 2002 - 11:14am

One technique for discovering small molecules of biological relevance is to expose cultured cells to a variety of small molecules and look for changes in the cells' appearance, behavior or other measurable qualities.

The Chemical Structure of DNA /biointeractive/chemical-structure-dna Animation Biochemistry, Nucleic acids, DNA Friday, February 5, 2010 - 11:17am

DNA's chemical properties can be harnessed for a variety of biotechnology applications.

Chemspace /biointeractive/chemspace Animation Chemistry, Science and society Tuesday, February 5, 2002 - 11:20am

The hypothetical relationship of chemical space and biological space is plotted on a three-dimensional graph, giving a glimpse of the future direction of research at the intersections of various disciplines.

The Cochlea /biointeractive/cochlea Animation Neuroscience Wednesday, February 5, 1997 - 11:26am

A dramatic illustration of how hearing happens in the ear. Also available in Spanish.

Bacterial Conjugation /biointeractive/bacterial-conjugation Animation Bacteria, Infectious disease, Cell signaling Friday, February 5, 1999 - 11:41am

Bacteria can transfer genetic material, and thus drug resistance, to other bacteria via conjugation.

Creating Embryonic Stem Cell Lines /biointeractive/creating-embryonic-stem-cell-lines Animation Developmental biology, Cell growth and division, Cell signaling, Stem cells Sunday, February 5, 2006 - 11:43am

The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells.

Cytoplasmic Factors /biointeractive/cytoplasmic-factors Animation Gene regulation, Developmental biology, Stem cells, Cell signaling Sunday, February 5, 2006 - 11:45am

Cytoplasmic factors play a significant part in determining how a cell develops. This segment discusses their importance in turning the appropriate genes on and off for proper development.

Dengue Virus Life Cycle /biointeractive/dengue-virus-life-cycle Animation Virus, RNA, Gene expression, Infectious disease Friday, February 5, 2010 - 3:33pm

Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for translating proteins.

Dengue Fever Re-Emergence in the Americas /biointeractive/dengue-fever-re-emergence-americas Animation Infectious disease, Science and society Friday, February 5, 2010 - 3:36pm

Since the 1960s dengue fever has spread to many countries and total case numbers have exploded.

Structure of Dengue Virus /biointeractive/structure-dengue-virus Animation Proteins, Virus, Infectious disease Friday, February 5, 2010 - 3:40pm

The dengue virus's outer envelope proteins form symmetrical units and overlay the lipid envelope, capsid, and the RNA genome.

Dengue Virus Enters a Cell /biointeractive/dengue-virus-enters-cell Animation Virus, Infectious disease, Cell structure Friday, February 5, 2010 - 3:43pm

Infection begins when the dengue virus uses receptors on an immune cell's surface to gain entry and release its genome.

Development of the human embryonic brain /biointeractive/development-human-embryonic-brain Animation Developmental biology, Neuroscience Tuesday, February 5, 2008 - 3:54pm

The fetal brain grows enormously during pregnancy, both in terms of its size and the number of neurons it has.

Differentiation and the Fate of Cells /biointeractive/differentiation-and-fate-cells Animation Developmental biology, Stem cells Sunday, February 5, 2006 - 3:57pm

As a human embryo develops, its cells become progressively restricted in the types of specialized cells that they can produce. Inner cell mass (ICM) cells of the blastocyst can make any type of body cell. Gastrula-stage cells can give rise to the cells of a given germ layer. Later, cells become even more restricted. For example, the pancreatic bud of the endoderm layer can only make the cells of the pancreas.

Diffusion Across Membranes /biointeractive/diffusion-across-membranes Animation Biochemistry, Cell structure Thursday, February 5, 1998 - 4:00pm

This animation describes two different ways by which chemicals migrate through membranes: passive diffusion and active transport.

Regulation of Eukaryotic DNA Transcription /biointeractive/regulation-eukaryotic-dna-transcription Animation DNA, RNA, Gene regulation Saturday, February 5, 2011 - 4:04pm

General transcription factors, activators, and repressors interact to regulate the transcription of eukaryotic DNA into RNA.

Building blocks of DNA /biointeractive/building-blocks-dna Animation Biochemistry, Nucleic acids, DNA Wednesday, February 5, 2003 - 4:06pm

Adenine (A), cytosine (C), guanine (G), and thymine (T) are the components of nucleic acid that make up DNA.

Chargaff's Ratio /biointeractive/chargaffs-ratio Animation Biochemistry, Nucleic acids, DNA Wednesday, February 5, 2003 - 4:09pm

In 1950, Erwin Chargaff published a paper stating that in the DNA of any given species, the ratio of adenine to thymine is equal, as is the ratio of cytosine to guanine. This became known as Chargaff's ratio, and it was an important clue for solving the structure of DNA.

CML and Gleevec /biointeractive/cml-and-gleevec Animation Proteins, Biochemistry, Cancer Wednesday, February 5, 2003 - 4:13pm

Chronic myeloid leukemia (CML) is caused by a mutation that leads to an abnormal protein that is always active. The drug Gleevec has a shape that fits into the active site of the abnormal protein and stops its harmful effects.

Coding sequences in DNA /biointeractive/coding-sequences-dna Animation Nucleic acids, DNA Wednesday, February 5, 2003 - 4:16pm

Of the 3 billion letters in the human genome, only 1% directly code for proteins. Of the rest, about 25% make up genes and their regulatory elements. The functions of the remaining letters are still unclear.

Damage to DNA leads to mutation /biointeractive/damage-dna-leads-mutation Animation Biochemistry, Nucleic acids, DNA Wednesday, February 5, 2003 - 4:24pm

Reactive molecules, such as free radicals, and solar ultraviolet radiation can lead to mutations in DNA. Most mutations are corrected, but in rare cases mutations can accumulate and cause diseases such as cancer.

Genetic engineering /biointeractive/genetic-engineering Animation Bacteria, DNA, Biotechnology Wednesday, February 5, 2003 - 4:27pm

A new gene can be inserted into a loop of bacterial DNA called a plasmid. This is done by cutting the plasmid DNA with a restriction enzyme, which allows a new piece of DNA to be inserted. The ends of the new piece of DNA are stitched together by an enzyme called DNA ligase. The genetically engineered bacteria will now manufacture any protein coded by genes on the newly inserted DNA.

Human chromosomes /biointeractive/human-chromosomes Animation DNA, Cell structure Wednesday, February 5, 2003 - 4:30pm

The human genome is organized into structures called chromosomes, consisting of 22 matching pairs and one pair of sex chromosomes.

Human genome sequencing /biointeractive/human-genome-sequencing Animation DNA, Genomics, Bioinformatics Wednesday, February 5, 2003 - 4:32pm

The public Human Genome Project started by identifying unique marker sequences distributed throughout the genome. Then, many copies of a small section of DNA were randomly cleaved into smaller fragments, and each small fragment was sequenced. Because there were originally many copies of the DNA in question, many fragments represented the same part of the genome. These were aligned by identifying overlapping regions of the sequence, and then they were assembled into the original DNA.

mRNA splicing /biointeractive/mrna-splicing Animation RNA Wednesday, February 5, 2003 - 4:34pm

Once a gene has been transcribed into messenger RNA (mRNA), it is edited in a process called splicing. Noncoding regions called introns are removed, leaving protein-coding regions called exons.

DNA packaging /biointeractive/dna-packaging Animation Proteins, Nucleic acids, DNA Wednesday, February 5, 2003 - 4:37pm

DNA is tightly packed in the nucleus of every cell. DNA wraps around special proteins called histones, which form loops of DNA called nucleosomes. These nucleosomes coil and stack together to form fibers called chromatin. Chromatin in turn forms larger loops and coils to form chromosomes.

Paired DNA strands /biointeractive/paired-dna-strands Animation Chemistry, Nucleic acids, DNA Wednesday, February 5, 2003 - 4:39pm

DNA has a double helix structure. If untwisted, DNA looks like two parallel strands. Each strand has a linear sequence of A, C, G, and T. The precise order of the letters carries the coded instructions. One strand is a complementary image of the other: A always pairs with T, and C always pairs with G.

Pauling triple helix model /biointeractive/pauling-triple-helix-model Animation Nucleic acids, Biochemistry, History of science Wednesday, February 5, 2003 - 4:42pm

One of the failed hypothetical models of DNA is Linus Pauling's triple helix model. This structure would be unstable under normal cellular conditions.

Polymerase chain reaction /biointeractive/polymerase-chain-reaction Animation Biochemistry, DNA, Biotechnology Wednesday, February 5, 2003 - 4:44pm

Polymerase chain reaction, or PCR, is a technique for making many copies of a specific DNA sequence. DNA is repeatedly heated and cooled in the presence of primers that bracket the desired sequence and of the enzyme Tac polymerase. In as few as 30 cycles, a billion copies of the target sequence can be made.

DNA replication (schematic) /biointeractive/dna-replication-schematic Animation Nucleic acids, DNA Wednesday, February 5, 2003 - 4:48pm

The structure of DNA, discovered by James Watson and Francis Crick, suggests a mechanism of replication. The double helix unwinds, and each strand acts as a template for the construction of the new DNA molecule. Also available in Spanish.

DNA replication (basic detail) /biointeractive/dna-replication-basic-detail Animation Nucleic acids, DNA Wednesday, February 5, 2003 - 4:51pm

Using information from molecular research, this 3-D animation shows how DNA is replicated at the molecular level. It involves an enzyme that unwinds the DNA, and other enzymes that copy the two resulting strands. Also available in Spanish.

DNA replication (advanced detail) /biointeractive/dna-replication-advanced-detail Animation Nucleic acids, DNA Wednesday, February 5, 2003 - 4:56pm

Both strands of the DNA double helix act as templates for the new DNA strands. Incoming DNA is unraveled by the enzyme helicase, resulting in the 3' strand and the 5' strand. The 3' strands and the 5' strands are replicated by a DNA polymerase enzyme but in different ways. Also available in Spanish.

Sanger method of DNA sequencing /biointeractive/sanger-method-dna-sequencing Animation Nucleic acids, DNA, Biotechnology Wednesday, February 5, 2003 - 4:59pm

Fred Sanger developed the first technique for sequencing DNA. DNA is replicated in the presence of chemically altered versions of the A, C, G, and T bases. These bases stop the replication process when they are incorporated into the growing strand of DNA, resulting in varying lengths of short DNA. These short DNA strands are ordered by size, and by reading the end letters from the shortest to the longest piece, the whole sequence of the original DNA is revealed.

Shotgun sequencing /biointeractive/shotgun-sequencing Animation DNA, Genomics, Bioinformatics, Biotechnology Wednesday, February 5, 2003 - 5:01pm

In shotgun sequencing many copies of the entire genome are "blown up" into millions of small fragments. Each small fragment is sequenced. Powerful computers then assemble the individual fragments into the original configuration. Repeat sequences pose a problem for this approach because their sizes can be much larger than the small fragments.

Sickle Cell Anemia /biointeractive/sickle-cell-anemia Animation DNA, Genetic basis of disease, Circulation Wednesday, February 5, 2003 - 5:04pm

Sickle cell anemia is a genetic disease that affects hemoglobin.

DNA transcription (basic detail) /biointeractive/dna-transcription-basic-detail Animation Nucleic acids, DNA, RNA Wednesday, February 5, 2003 - 5:06pm

The first phase of the process of reading DNA information to make proteins starts with a molecule unzipping the DNA. The molecule then copies one of the strands of DNA into a strand of RNA, a close cousin of DNA. This process is called transcription. Also available in Spanish.

DNA transcription (advanced detail) /biointeractive/dna-transcription-advanced-detail Animation Nucleic acids, DNA, RNA Wednesday, February 5, 2003 - 5:09pm

The process of copying DNA into messenger RNA (mRNA) is called transcription. Transcription factors assemble at the promoter region of a gene, bringing an RNA polymerase enzyme to form the transcription initiation complex. Activator proteins at the enhancer region of DNA then activate the transcription initiation complex. RNA polymerase unzips a small portion of the DNA and copies one strand into an mRNA molecule. Also available in Spanish.

Translation (basic detail) /biointeractive/translation-basic-detail Animation RNA, Gene expression Wednesday, February 5, 2003 - 5:11pm

The ribosome is a molecular factory that translates the genetic information in RNA into a string of amino acids that becomes a protein. Inside the ribosome, the genetic code of the RNA is read three letters at a time and compared with the corresponding code on a transfer molecule. When a match occurs between the codes, the amino acid carried by the transfer molecule is added to the growing protein chain. Also available in Spanish.

Translation (advanced detail) /biointeractive/translation-advanced-detail Animation RNA Wednesday, February 5, 2003 - 5:13pm

Messenger RNA (mRNA) carries DNA's genetic information to the ribosome, where it is translated into a sequence of amino acids. mRNA is fed into the ribosome, and it is positioned so that it can be read in groups of three letters, known as codons. Each mRNA codon is matched against the transfer RNA molecule's anti-codon. If there is a match, the amino acid carried by the transfer RNA is added to the growing protein chain. Also available in Spanish.

Triplet code /biointeractive/triplet-code Animation Proteins, DNA Wednesday, February 5, 2003 - 5:15pm

Once the structure of DNA was discovered, the next challenge was determining how the sequence of letters coded for the 20 amino acids. In theory, one or two letters can only code for 4 or 16 amino acids, respectively. A scheme using three letters, a triplet code, is the minimum necessary to encode for all the amino acids.

Watson constructing base pair models /biointeractive/watson-constructing-base-pair-models Clip Biochemistry, Nucleic acids, DNA, History of science Wednesday, February 5, 2003 - 5:17pm

During the process of trying to elucidate the structure of DNA, Jim Watson made some cardboard models to try to understand how DNA nucleotides are paired. It helped him visualize how hydrogen atoms of paired nucleotides interact with each other to form a symmetrical structure that fits the double helix model.

DOS Matrix /biointeractive/dos-matrix Animation Chemistry Tuesday, February 5, 2002 - 5:20pm

In diversity-oriented synthesis, many combinations of chemical building blocks undergo relatively few reaction steps to form a vast variety of different molecules. In this example, 45 x 45 x 45 combinations yield more than 88,000 novel molecules.

The Drosophila Molecular Clock Model /biointeractive/drosophila-molecular-clock-model Animation Gene regulation, Behavior, Cell signaling Saturday, February 5, 2000 - 5:23pm

Watch these animations display the dynamic orchestration of the molecular events of the Drosophila biological clock.

Molecular basis of early LTP (short-term memory) /biointeractive/molecular-basis-early-ltp-short-term-memory Animation Neuroscience, Cell signaling Tuesday, February 5, 2008 - 5:28pm

Early LTP (short-term memory) depends on a calcium-dependent protein kinase to strengthen an existing synapse.

E. coli Infection Strategy /biointeractive/e-coli-infection-strategy Animation Bacteria, Infectious disease Friday, February 5, 1999 - 5:31pm

Watch this animation to see the molecular tricks that an infectious strain of Escherichia coli uses to infect your gut.

Exclusion Mapping /biointeractive/exclusion-mapping Animation Bioinformatics, Mendelian inheritance, Genetic basis of disease, Scientific methodology Wednesday, February 5, 2003 - 5:34pm

A useful technique for narrowing down the location of a gene involves comparing the chromosomes of affected siblings. Two sisters with Rett syndrome allow researchers an opportunity to map the most likely location of the gene by excluding areas of the chromosome that are not alike.

The Fate of Fat /biointeractive/fate-fat Animation Nutrition Thursday, February 5, 2004 - 5:37pm

An overview of how dietary fat gets digested, packaged, and sent to various tissues for storage or energy.

Furrowstatin /biointeractive/furrowstatin Clip Chemistry, Cell growth and division Tuesday, February 5, 2002 - 5:39pm

The small molecule 'furrowstatin' exemplifies the power of using small molecules to investigate life's processes. When applied to dividing cells, the furrowstatin halts cell division.

Gene Chip Manufacturing /biointeractive/gene-chip-manufacturing Animation Genomics, Bioinformatics, Biotechnology Tuesday, February 5, 2002 - 5:42pm

Gene chips, also called DNA microarrays, have a broad range of applications in current research, including enabling researchers to measure the activity of thousands of genes simultaneously. Dr. Eric Lander describes the process used to manufacture gene chips.

Gene Switch /biointeractive/gene-switch Animation Mechanisms of evolution, Gene regulation Saturday, February 5, 2005 - 5:44pm

Regulatory "switches" are found upstream from a gene. Regulatory molecules bind to the switches and recruit RNA polymerase to bind to the gene's promoter region, increasing the transcription of the gene into messenger RNA.

Gleevec /biointeractive/gleevec Animation Proteins, Biochemistry, Genetic basis of disease, Cancer Wednesday, February 5, 2003 - 6:20pm

Gleevec is a drug designed to interfere with the stimulation of growth in leukemia cells. This 3D animation shows how this is achieved.

Obesity-Related Health Problems /biointeractive/obesity-related-health-problems Animation Nutrition, Circulation Thursday, February 5, 2004 - 6:23pm

A timeline illustrating the gradual effects of obesity on the body, including diabetes, atherosclerosis, and heart attack.

How a Heart Attack Occurs /biointeractive/how-heart-attack-occurs Animation Nutrition, Circulation Thursday, February 5, 2004 - 6:26pm

A 3-D animation that shows how plaques form in a blood vessel, leading to blockage and a heart attack.

Heart Function /biointeractive/heart-function Animation Circulation Thursday, February 5, 1998 - 6:28pm

The job of the human heart—in fact of all vertebrate hearts—is to pump oxygenated blood throughout the cells of the body and to return deoxygenated blood to lungs or gills for replenishment.

HIV life cycle /biointeractive/hiv-life-cycle Animation Virus, RNA, Gene expression, Infectious disease, Cell structure Monday, February 5, 2007 - 6:31pm

How HIV infects a cell and replicates itself using reverse transcriptase and the host's cellular machinery.

Human Embryonic Development /biointeractive/human-embryonic-development Animation Developmental biology, Stem cells Sunday, February 5, 2006 - 6:40pm

Human embryonic development depends on stem cells. During the course of development, cells divide, migrate, and specialize. Early in development, a group of cells called the inner cell mass (ICM) forms. These cells are able to produce all the tissues of the body. Later in development, during gastrulation, the three germ layers form, and most cells become more restricted in the types of cells that they can produce.

Location of the Hypothalamus /biointeractive/location-hypothalamus Animation Neuroscience, Nutrition Thursday, February 5, 2004 - 6:45pm

A 3-D animation that shows the location of the hypothalamus in a mouse's brain.

Lactose Digestion in Infants /biointeractive/lactose-digestion-infants Animation Biochemistry, Carbohydrates, Nutrition Wednesday, March 7, 2012 - 6:47pm

The lactase enzyme is produced in the small intestine of infants. It digests lactose by breaking it into glucose and galactose.

Natural Selection of Lactose Tolerance /biointeractive/natural-selection-lactose-tolerance Animation Evolution of populations, Population genetics Saturday, February 5, 2011 - 6:50pm

Environmental and cultural factors can affect whether a new human mutation becomes common in a population.

Molecular basis of late LTP (long-term memory) /biointeractive/molecular-basis-late-ltp-long-term-memory Animation Neuroscience, Cell signaling Tuesday, February 5, 2008 - 6:52pm

Late LTP (long-term memory) involves dopamine activation of CREB to support new synaptic growth.

Leptin Feedback Control System /biointeractive/leptin-feedback-control-system Animation Nutrition, Behavior, Cell signaling Thursday, February 5, 2004 - 6:54pm

Demonstrates how changes in the amount of fat tissue lead to changes in leptin levels and thus changes in appetite.

Leptin Neuronal Rewiring /biointeractive/leptin-neuronal-rewiring Animation Neuroscience, Nutrition Thursday, February 5, 2004 - 6:57pm

Illustrates how providing leptin to an obese mouse rapidly rewires its hypothalamus neurons.

Lightning-strike cabal acts like a Taser /biointeractive/lightning-strike-cabal-acts-taser Animation Biochemistry, Neuroscience Thursday, February 5, 2009 - 7:00pm

Some cone snail toxins chemically hyperactivate neurons and immobilize prey, much like a Taser.

The LUX operon controls light production /biointeractive/lux-operon-controls-light-production Animation Biochemistry, Bacteria, Gene regulation, Cell signaling Thursday, February 5, 2009 - 7:02pm

A single transcription factor controls this operon, which contains five genes necessary to produce bioluminescence.

Malaria: Human Host /biointeractive/malaria-human-host Animation Protists, Infectious disease Tuesday, February 5, 2013 - 7:04pm

When a malaria-carrying mosquito bites a human host, the malaria parasite enters the bloodstream, multiplies in the liver cells, and is then released back into the bloodstream, where it infects and destroys red blood cells.

Malaria: Mosquito Host /biointeractive/malaria-mosquito-host Animation Protists, Infectious disease Tuesday, February 5, 2013 - 7:06pm

A mosquito becomes infected with malaria when it sucks the blood from an infected human. Once inside the mosquito, the parasites reproduce in the gut and accumulate in the salivary glands, ready to infect another human host with the next bite.

Adhering to an antiretroviral regimen /biointeractive/adhering-antiretroviral-regimen Clip Virus, Infectious disease Tuesday, February 6, 2007 - 10:25am

Adam Barrett describes his seven-drug antiretroviral regimen and the importance of adherence.

Demo: Meet a live Aplysia californica /biointeractive/demo-meet-live-aplysia-californica Clip Animals, Neuroscience Wednesday, February 6, 2008 - 10:28am

Aplysia californica is a marine snail with a simple nervous system suitable for research on learning and memory.

Aplysia's gill-withdrawal reflex and sensitization /biointeractive/aplysias-gill-withdrawal-reflex-and-sensitization Clip Animals, Neuroscience, Behavior Wednesday, February 6, 2008 - 10:31am

A touch to the Aplysia's siphon causes a gill withdrawal, a simple reflex for studying memory.

Interview with Dr. Huda Zoghbi /biointeractive/interview-dr-huda-zoghbi Interview Careers in science Thursday, February 6, 2003 - 10:35am

An interview with Dr. Zoghbi.

Demo: Electrical measurement of muscle activity /biointeractive/demo-electrical-measurement-muscle-activity Clip Skin, muscles, and bones, Neuroscience, Cell signaling Wednesday, February 6, 2008 - 11:17am

A live recording of muscle activity from Dr. Jessell's biceps and triceps muscles.

Interview with Kwame Atsina /biointeractive/interview-kwame-atsina Interview Careers in science Tuesday, February 6, 2007 - 11:21am

An interview with Kwame Atsina, an undergraduate who discusses what it's like to be in a lab doing scientific research.

Bacterial Growth /biointeractive/bacterial-growth Clip Bacteria, Cell growth and division Saturday, February 6, 1999 - 11:23am

Dr. Brett Finlay shows how bacteria can grow rapidly to incredible numbers, and also explains what limits this explosive growth.

Regulation of Sex Determination in C. elegans /biointeractive/regulation-sex-determination-c-elegans Clip Gene regulation, Reproduction, Cell signaling Tuesday, February 6, 2001 - 11:25am

A demonstration by Dr. Meyer showing how a balance of molecular elements trigger genetic pathways that determine the sex of a C. elegans worm.

Which Balloon Has Hydrogen? /biointeractive/which-balloon-has-hydrogen Clip Chemistry, Scientific methodology Monday, February 6, 1995 - 11:27am

Air is an invisible gas as are hydrogen and helium. How can you tell if a balloon contains hydrogen? Hydrogen has particular physical and chemical properties that can be tested. Dr. Cech enlists student volunteers to show how a chemical reaction can be used to identify a substance.

Interview with Grant Barish /biointeractive/interview-grant-barish Interview Careers in science Friday, February 6, 2004 - 11:31am

An interview with Grant Barish, a scientist in Dr. Evans's lab.

Adherence and resistance /biointeractive/adherence-and-resistance Clip Virus, Neuroscience Tuesday, February 6, 2007 - 11:33am

Adam Barrett, a nurse who is HIV positive, discusses his first symptoms and the challenges of adhering to a drug regimen.

Barrios Battling Dengue /biointeractive/barrios-battling-dengue Clip Infectious disease, Science and society Saturday, February 6, 2010 - 11:36am

The fight against dengue fever, and the mosquitoes that carry the virus, is being carried out by "brigadistas" in Managua's neighborhoods. Spanish with English subtitles.

Interview with Bonnie Bassler /biointeractive/interview-bonnie-bassler Interview Careers in science Friday, February 6, 2009 - 11:39am

An interview with Dr. Bassler.

Bee Colony Collapse Disorder /biointeractive/bee-colony-collapse-disorder Clip Virus, Animals, Infectious disease Saturday, February 6, 2010 - 12:28pm

Charles Runckel, a graduate student in the DeRisi lab, uses the Virochip to examine the mystery of bee colony collapse disorder.

Benefits of an antiretroviral regimen /biointeractive/benefits-antiretroviral-regimen Clip Virus, Infectious disease Tuesday, February 6, 2007 - 12:32pm

Zinhle Thabethe describes how antiretroviral therapy has changed her life.

Interview with Dr. Seymour Benzer /biointeractive/interview-dr-seymour-benzer Interview Behavior Sunday, February 6, 2000 - 12:46pm

Are you a night owl or a morning lark? Noted researcher Dr. Seymour Benzer discusses how the difference between he and his wife sparked his interest in the topic of biological clocks.

Bobtail squid swimming and burrowing /biointeractive/bobtail-squid-swimming-and-burrowing Clip Animals, Behavior Friday, February 6, 2009 - 12:48pm

The bobtail squid swims during the night to hunt. During the day, it burrows to hide from predators.

Dosage Compensation in C. elegans /biointeractive/dosage-compensation-c-elegans Clip Reproduction, Developmental biology, Cell signaling Tuesday, February 6, 2001 - 12:50pm

A demonstration by Dr. Barbara Meyer of how a branched genetic pathway can be affected by mutations in different parts of the pathway.

Breeding Corn from Teosinte /biointeractive/breeding-corn-teosinte Clip Artificial selection, Plants Sunday, February 6, 2005 - 12:51pm

Corn was originally bred from the teosinte plant by native Mexican farmers. The morphologies of modern-day corn and teosinte plants are compared to illustrate how artificial selection can bring about dramatic changes in plants.

Interview with Silvia Caballero /biointeractive/interview-silvia-caballero Interview Infectious disease, Cell signaling, Careers in science Tuesday, February 6, 2007 - 12:53pm

An interview with Silvia Caballero, an undergraduate who discusses what it's like to be in a lab doing scientific research.

Interview with Josh Carlson /biointeractive/interview-josh-carlson Interview Careers in science Sunday, February 6, 2011 - 12:55pm

Mr. Carlson outlines the path that he took to becoming a graduate student in the White lab, including his experience as a chef.

Interview with Sean Carroll /biointeractive/interview-sean-carroll Interview Mechanisms of evolution, Careers in science Sunday, February 6, 2005 - 12:57pm

An interview with Dr. Carroll.

Cat remembers obstacle location for many minutes /biointeractive/cat-remembers-obstacle-location-many-minutes Clip Neuroscience, Behavior Wednesday, February 6, 2008 - 12:59pm

Even when distracted by food, the cat's brain encodes and retains the location of an obstacle.

Oxalate Catalysis /biointeractive/oxalate-catalysis Clip Chemistry Monday, February 6, 1995 - 1:01pm

Without an appropriate catalyst some chemical reactions would be so slow as to appear not to occur at all on the human timescale. However, when catalyzed, these reactions can be very dramatic.

On Becoming a Scientist: Dr. Thomas Cech /biointeractive/becoming-scientist-dr-thomas-cech Interview Science and society Monday, February 6, 1995 - 1:04pm

HHMI President Dr. Thomas Cech discusses the path he took to become a scientist and his reaction to receiving the Nobel Prize.

Embryonic Cell Division in C. elegans /biointeractive/embryonic-cell-division-c-elegans Clip Reproduction, Developmental biology, Cell growth and division Tuesday, February 6, 2001 - 1:05pm

Time-lapse microscopy showing cell division from 1 to 2 to 4 cell stages in C. elegans with fluorescent chromosomes.

From Fertilization to Egg Laying in C. elegans /biointeractive/fertilization-egg-laying-c-elegans Clip Animals, Behavior, Reproduction, Developmental biology Tuesday, February 6, 2001 - 1:08pm

Video of the fertilization of the C. elegans oocyte, the fusion of the egg and sperm nuclei, and the egg laying.

C. elegans Mating /biointeractive/c-elegans-mating Clip Animals, Behavior, Reproduction Tuesday, February 6, 2001 - 1:10pm

Video microscopy of mating between a male and a hermaphrodite C. elegans roundworm.

Amoeboid Sperm of C. elegans /biointeractive/amoeboid-sperm-c-elegans Clip Animals, Reproduction, Cell structure Tuesday, February 6, 2001 - 1:13pm

Video closeup of the C. elegans sperm that moves like an amoeba.

The Central Dogma Song /biointeractive/central-dogma-song Clip DNA, Gene expression Saturday, February 6, 2010 - 1:15pm

“The Assemblers” (Peter Skewes-Cox and Dr. Graham Ruby) sing about DNA and proteins.

Cheek Cells and Bacteria /biointeractive/cheek-cells-and-bacteria Clip Bacteria Saturday, February 6, 1999 - 1:18pm

Dr. Brett Finlay enlists a student volunteer to show the surprisingly high amount of bacteria found in his own mouth.

Rett Syndrome /biointeractive/rett-syndrome Clip Neuroscience, Behavior, Developmental biology Thursday, February 6, 2003 - 1:20pm

Dr. Zoghbi introduces the topic of Rett syndrome by showing how development usually progresses in a young girl. She then shows an excerpt from Silent Angels, introduced by Julia Roberts, which shows how Rett syndrome affects development.

Clonal vs Sexual Reproduction /biointeractive/clonal-vs-sexual-reproduction Clip Mechanisms of evolution, Reproduction Tuesday, February 6, 2001 - 1:22pm

What does a stack of fruits and vegetables have to do with the theoretical advantages of sexual reproduction? Find out in this demonstration with student audience members and Dr. David Page.

Polyp Removal /biointeractive/polyp-removal Clip Cancer Thursday, February 6, 2003 - 1:24pm

Dr. Vogelstein shows video taken during a colonoscopy and the removal of a polyp.

Computer analysis of human movement /biointeractive/computer-analysis-human-movement Clip Skin, muscles, and bones, Neuroscience, Behavior Wednesday, February 6, 2008 - 1:27pm

Dr. Jessell's leg muscle activation patterns are recorded during walking.

A patient with conduction aphasia /biointeractive/patient-conduction-aphasia Clip Neuroscience Wednesday, February 6, 2008 - 1:29pm

A patient can both comprehend and articulate language, but cannot verbalize what is a clear idea in her mind.

Demonstration: Live Cone Snail /biointeractive/demonstration-live-cone-snail Clip Biodiversity, Animals Friday, February 6, 2009 - 1:31pm

Dr. Olivera demonstrates a live specimen of Conus striatus.

Contact repulsion of a growth cone /biointeractive/contact-repulsion-growth-cone Clip Developmental biology, Neuroscience, Cell signaling Wednesday, February 6, 2008 - 1:33pm

A growth cone contacts a repellant molecule on another axon, collapses, and withdraws.

Conus bullatus "lightning strike" /biointeractive/conus-bullatus-lightning-strike Clip Biodiversity, Animals, Behavior Friday, February 6, 2009 - 1:37pm

This species of cone snail immobilizes its prey in a split second with lightning-strike cabal toxins.

Conus catus strikes a fish /biointeractive/conus-catus-strikes-fish Clip Biodiversity, Animals, Behavior Friday, February 6, 2009 - 1:39pm

A fish-hunting cone snail strikes its prey with a venomous harpoon, causes paralysis, and eats it.

Demonstration: Conus geographus can kill you /biointeractive/demonstration-conus-geographus-can-kill-you Clip Biodiversity, Animals, Neuroscience Friday, February 6, 2009 - 1:41pm

Larger cone snails produce more venom and are more dangerous to human beings in an accidental stinging.

Conus imperialis strikes a worm /biointeractive/conus-imperialis-strikes-worm Clip Biodiversity, Animals, Behavior Friday, February 6, 2009 - 1:44pm

A worm-hunting cone snail species feeds on fireworms, and is unaffected by the prey's sharp bristles.

Conus striatus strikes a fish /biointeractive/conus-striatus-strikes-fish Clip Biodiversity, Animals, Behavior Friday, February 6, 2009 - 1:46pm

A species of fish-hunting cone snail quickly immobilizes its prey and swallows it.

Conus textile strikes a snail /biointeractive/conus-textile-strikes-snail Clip Biodiversity, Animals, Behavior Friday, February 6, 2009 - 1:49pm

A snail-hunting species of cone snail stings its prey repeatedly, inducing the prey to thrash about.

Conus tulipa hunts fish by net /biointeractive/conus-tulipa-hunts-fish-net Clip Biodiversity, Animals, Behavior Friday, February 6, 2009 - 1:53pm

Unlike a hook-and-line type fish-hunter, a net-hunting cone snail lures its prey into its wide mouth.

CTL killing a target cell /biointeractive/ctl-killing-target-cell Clip Immunology, Cell signaling Tuesday, February 6, 2007 - 1:55pm

Video microscopy of a cytotoxic T lymphocyte in action.

Antlers and Mammalian Regeneration /biointeractive/antlers-and-mammalian-regeneration Clip Stem cells, Cell growth and division Monday, February 6, 2006 - 1:57pm

Dr. Rosenthal describes how antlers are one of the few examples of complete mammalian regeneration.

Demo: Student adherence activity /biointeractive/demo-student-adherence-activity Clip Infectious disease, Science and society Tuesday, February 6, 2007 - 1:58pm

Using tic tac mints as anti-HIV drug stand-ins, students experience the challenges of adhering to an antiretroviral regimen.

Demo: Rapid AIDS virus test /biointeractive/demo-rapid-aids-virus-test Clip Infectious disease, Science and society, Biotechnology Tuesday, February 6, 2007 - 2:02pm

A live demonstration of how a rapid antibody-based HIV test works.

Impact of Nicaraguan Dengue Project /biointeractive/impact-nicaraguan-dengue-project Clip Infectious disease, Science and society Saturday, February 6, 2010 - 2:04pm

Several members of a Nicaraguan research team describe the impact of technology transfer.

Interview with Joe DeRisi PhD /biointeractive/interview-joe-derisi-phd Interview Infectious disease, Careers in science, Biotechnology Saturday, February 6, 2010 - 2:07pm

An interview with Dr. DeRisi.

Dog Breeding /biointeractive/dog-breeding Clip Artificial selection, Animals Sunday, February 6, 2005 - 2:09pm

The many forms of dogs that exist today were all created through selective breeding from the dog's ancestor, the wolf. In a span of less than 10,000 years, breeders have changed traits and body shapes of dogs by artificial selection-for example, emphasizing different aspects of hunting and herding behavior.

Diversity-Oriented Synthesis /biointeractive/diversity-oriented-synthesis Clip Chemistry, Biotechnology Wednesday, February 6, 2002 - 2:11pm

Diversity-oriented synthesis (DOS) is a strategy used by chemical biologists to create a huge diversity of small molecules with potentially useful properties. A scientist working in Dr. Stuart Schreiber's lab shows us how engineering, computer science, chemisty, and biology are all used in DOS.

Dung Beetles and their Fossilized Evidence /biointeractive/dung-beetles-and-their-fossilized-evidence Clip Paleobiology, Behavior Sunday, February 6, 2011 - 2:13pm

Fossilized dung beetle balls are part of a comprehensive fossil collection project to reconstruct the habitat of Ardipithecus ramidus.

Echocardiogram /biointeractive/echocardiogram Clip Circulation Friday, February 6, 1998 - 2:15pm

Dr. Christine Seidman describes a live demonstration of an echocardiogram, with a description of the parts of the heart that are visualized.

Interview with Dr. Ronald Evans /biointeractive/interview-dr-ronald-evans Interview Careers in science Friday, February 6, 2004 - 2:17pm

An interview with Dr. Evans.

Interview with Jennifer Everhart /biointeractive/interview-jennifer-everhart Interview Careers in science Sunday, February 6, 2011 - 2:19pm

Ms. Everhart recounts her fieldwork experiences as a member of the Shea lab and the results of her first flintknapping attempt.

Interview with Brett Finlay /biointeractive/interview-brett-finlay Interview Careers in science Saturday, February 6, 1999 - 2:20pm

An interview with Dr. Finlay.

Making Stone Tools by Flintknapping /biointeractive/making-stone-tools-flintknapping Clip Paleobiology, Human evolution Sunday, February 6, 2011 - 2:23pm

Stone tools similar to those found at prehistoric archaeological sites can be made by fracturing rocks, a technique known as flintknapping.

Floods Supply Sediments for Fossil Formation /biointeractive/floods-supply-sediments-fossil-formation Clip Paleobiology, Scientific methodology Sunday, February 6, 2011 - 2:25pm

The floor of a rift valley is prone to periodic floods that carry in fine silt--the sedimentary matter responsible for fossil formation.

Fruit Fly Courtship /biointeractive/fruit-fly-courtship Clip Animals, Behavior Sunday, February 6, 2005 - 2:35pm

Male courtship dances in two fruit fly species show that the wing spots play a prominent role.

The Delicate Process of Excavating and Cleaning Fossils /biointeractive/delicate-process-excavating-and-cleaning-fossils Clip Paleobiology, Scientific methodology Sunday, February 6, 2011 - 3:21pm

Fossils are extremely fragile. Scientists remove them in a protective layer of plaster and clean sand away one grain at a time.

Interview with Dr. Jeffrey Friedman /biointeractive/interview-dr-jeffrey-friedman Interview Careers in science Friday, February 6, 2004 - 3:23pm

An interview with Dr. Friedman.

Galapagos Creatures /biointeractive/galapagos-creatures Clip Evolutionary theory, Biodiversity, Animals Sunday, February 6, 2005 - 3:25pm

These are some of the animal species Charles Darwin would have seen when he visited the Galapagos Islands.

Interview with Don Ganem /biointeractive/interview-don-ganem Interview Careers in science Saturday, February 6, 1999 - 3:26pm

An interview with Dr. Ganem.

Interview with Jennifer Gatchel /biointeractive/interview-jennifer-gatchel Interview Careers in science Thursday, February 6, 2003 - 3:29pm

An interview with Jennifer Gatchel, a scientist in Dr. Zoghbi's lab.

Living with HIV /biointeractive/living-hiv Clip Virus, Infectious disease, Science and society Tuesday, February 6, 2007 - 3:31pm

Catherine Gaynes, an HIV-positive patients, discusses her HIV diagnosis, how her family reacted, and avoiding HIV infection.

Demonstration: Glowing bacteria in a flask /biointeractive/demonstration-glowing-bacteria-flask Clip Bacteria, Cell signaling Friday, February 6, 2009 - 3:33pm

Dr. Bassler demonstrates the bioluminescence of a culture of Vibrio harveyi.

Interview with Felicia Gomez /biointeractive/interview-felicia-gomez Interview Careers in science Sunday, February 6, 2011 - 3:36pm

Ms. Gomez explains her research in the Tishkoff lab and how it may help in understanding malaria resistance.

First AIDS patients /biointeractive/first-aids-patients Clip Infectious disease, History of science Tuesday, February 6, 2007 - 3:38pm

Dr. Michael Gottlieb was the first physician to notice the new disease of AIDS.

Interview with Amy Greenwood and Alice Chen /biointeractive/interview-amy-greenwood-and-alice-chen Interview Careers in science Monday, February 6, 2006 - 3:40pm

An interview with Amy Greenwood and Alice Chen, two scientists in Dr. Melton's lab.

Growth cones in action /biointeractive/growth-cones-action Clip Developmental biology, Neuroscience, Cell growth and division Wednesday, February 6, 2008 - 3:42pm

The growth cones of two neurons sense and interact with one another.

Origin of HIV /biointeractive/origin-hiv Clip Virus, Genetic basis of disease Tuesday, February 6, 2007 - 3:44pm

Dr. Beatrice Hahn's research has traced the origin of HIV to chimpanzees in Cameroon.

Interview with Dr. Adam Hantman /biointeractive/interview-dr-adam-hantman Interview Careers in science Wednesday, February 6, 2008 - 3:46pm

An interview with Dr. Adam Hantman, a post-doctoral student in Thomas Jessell's lab.

Hardening Fragile Fossils for Extraction /biointeractive/hardening-fragile-fossils-extraction Clip Paleobiology, Scientific methodology Sunday, February 6, 2011 - 3:48pm

Due to the delicate nature of fossils, a hardening chemical is dripped onto every fossil before it is removed from the soil.

Interview with Eva Harris PhD /biointeractive/interview-eva-harris-phd Interview Careers in science, Science and society Saturday, February 6, 2010 - 3:50pm

An interview with Dr. Harris.

Health Brigades in Managua's Neighborhoods /biointeractive/health-brigades-managuas-neighborhoods Clip Infectious disease, Science and society Saturday, February 6, 2010 - 3:51pm

In the effort to eradicate dengue and mosquitoes, neighborhood leaders work with local conditions.

Heart Attack and Blocked Arteries /biointeractive/heart-attack-and-blocked-arteries Clip Circulation Monday, February 6, 2006 - 3:53pm

Dr. Rosenthal uses a model of a heart and an artery to describe how blockages lead to heart attack and tissue damage.

Interview with Tessa Hirschfeld-Stoler /biointeractive/interview-tessa-hirschfeld-stoler Interview Careers in science Wednesday, February 6, 2008 - 3:57pm

An interview with Tessa Hirschfeld-Stoler, a lab technician in Eric Kandel's lab.

Interview with Chris Hittinger /biointeractive/interview-chris-hittinger Interview Careers in science Sunday, February 6, 2005 - 3:59pm

An interview with Chris Hittinger, a scientist in Dr. Carroll's lab.

HIV's origins in Africa /biointeractive/hivs-origins-africa Clip Virus, Infectious disease Tuesday, February 6, 2007 - 4:03pm

Dr. Beatrice Hahn discusses how HIV originated in Africa by cross-species transmission from chimpanzees to humans.

Comparing Human and Chimpanzee Tool Use /biointeractive/comparing-human-and-chimpanzee-tool-use Clip Human evolution, Animals, Behavior Monday, February 7, 2011 - 1:42pm

Chimpanzees are capable of using rocks as tools to crack nuts for eating. But they don't appear to use sharp-edged tools.

Cultured Human Embryonic Stem Cells /biointeractive/cultured-human-embryonic-stem-cells Clip Stem cells, Cell growth and division Tuesday, February 7, 2006 - 1:48pm

Cell cultures derived from human embryonic stem cells can reproduce indefinitely and also differentiate into specialized cell types, including beating heart cells.

Ian Waterman: Compensating for proprioceptive loss /biointeractive/ian-waterman-compensating-proprioceptive-loss Clip Neuroscience, Behavior Thursday, February 7, 2008 - 1:51pm

In the absence of proprioceptive feedback, some individuals can compensate by using visual feedback.

Intracytoplasmic Sperm Injection (ICSI) /biointeractive/intracytoplasmic-sperm-injection-icsi Clip Reproduction, Developmental biology, Biotechnology Wednesday, February 7, 2001 - 1:54pm

Video microscopy demonstrating how sperm from an infertile male can be injected into a female egg.

Listeria Infection Demonstration /biointeractive/listeria-infection-demonstration Clip Bacteria, Infectious disease Sunday, February 7, 1999 - 1:57pm

Dr. Finlay and a student volunteer show how Listeria infects a cell, using a marble and some yellow gelatin.

Salmonella Infection Demonstration /biointeractive/salmonella-infection-demonstration Clip Bacteria, Infectious disease Sunday, February 7, 1999 - 2:01pm

Dr. Finlay and another student volunteer illustrate how Salmonella infects a cell, using a marble, plastic wrap, and some yellow gelatin.

Interview with Dr. Thomas Jessell /biointeractive/interview-dr-thomas-jessell Interview Careers in science Thursday, February 7, 2008 - 2:05pm

An interview with Dr. Jessell.

Muscle activity during walking and hopping /biointeractive/muscle-activity-during-walking-and-hopping Clip Skin, muscles, and bones, Neuroscience, Behavior Thursday, February 7, 2008 - 2:08pm

Electrical activity recorded from the leg muscles reveals different patterns of activation during different gaits.

Interview with Jose Gonzales /biointeractive/interview-jose-gonzales Interview Careers in science Tuesday, February 7, 2006 - 2:15pm

An interview with Dr. Jose Gonzales, Manager of the Laboratory Animal Resources and Knockout Mouse Facility at EMBL in Monterotondo Italy.

Interview with Manolis Kamvysselis /biointeractive/interview-manolis-kamvysselis Interview Careers in science Thursday, February 7, 2002 - 2:19pm

An interview with Manolis Kamvysselis, a scientist in Dr. Lander's lab.

Interview with Dr. Eric Kandel /biointeractive/interview-dr-eric-kandel Interview Neuroscience, Careers in science Thursday, February 7, 2008 - 2:21pm

An interview with Dr. Kandel.

Kidney Function /biointeractive/kidney-function Clip Circulation Saturday, February 7, 1998 - 2:23pm

Dr. Richard Lifton, along with student volunteers, uses an aquarium and salt to illustrate the amount of work the kidney performs each day to maintain proper levels of ions in the body.

Interview with David Kingsley /biointeractive/interview-david-kingsley Interview Skin, muscles, and bones, Careers in science Monday, February 7, 2005 - 2:26pm

An interview with Dr. Kingsley.

Interview with Angela Koehler /biointeractive/interview-angela-koehler Interview Careers in science Thursday, February 7, 2002 - 2:29pm

An interview with Angela Koehler, a scientist in Dr. Schreiber's lab.

Interview with Dr. Ron Konopka /biointeractive/interview-dr-ron-konopka Interview Gene regulation, Behavior Monday, February 7, 2000 - 2:31pm

Dr. Benzer is joined by Dr. Ron Konopka for a brief discussion of how the per gene is involved in mammalian clocks.

Interview with Dr. Eric Lander /biointeractive/interview-dr-eric-lander Interview Careers in science Thursday, February 7, 2002 - 2:39pm

An interview with Dr. Lander.

Long-distance neuronal path-finding /biointeractive/long-distance-neuronal-path-finding Clip Developmental biology, Neuroscience, Cell signaling Thursday, February 7, 2008 - 2:42pm

Retinal axons travel across the brain, reading navigation cues, to find appropriate targets.

Leading-Edge Bioinformatics /biointeractive/leading-edge-bioinformatics Clip Genomics, Bioinformatics, Careers in science Sunday, February 7, 2010 - 2:45pm

Peter Skewes-Cox, and Dr. Graham Ruby, both in the DeRisi lab, explain state-of-the-art DNA sequencing and bioinformatic technologies.

Listeria Video /biointeractive/listeria-video Clip Bacteria, Infectious disease Sunday, February 7, 1999 - 2:48pm

This microscope video shows how live Listeria move via actin filaments in an infected cell.

Salmonella Video /biointeractive/salmonella-video Clip Bacteria, Infectious disease Sunday, February 7, 1999 - 2:56pm

Salmonella are a common bacteria associated with food poisoning. Dr. Finlay shows live Salmonella under the microscope to demonstrate how far and fast they can move.

Managua: Rapid, Unplanned Urbanization /biointeractive/managua-rapid-unplanned-urbanization Clip Science and society Sunday, February 7, 2010 - 2:58pm

Poor management of drainage, drinking water, and wastewater, makes excellent mosquito habitat.

Surrounded by the Ocean: Philippine Maritime Culture, Biodiversity, and Research /biointeractive/surrounded-ocean-philippine-maritime-culture-biodiversity-and-research Scientists at Work Biodiversity, Human impacts, Science and society Saturday, February 7, 2009 - 3:01pm

A mini-documentary illustrating the importance of the ocean to the Filipino way of life, and how that close connection helps biodiversity research.

Interview with Michael McIntosh /biointeractive/interview-michael-mcintosh Interview Biodiversity, Neuroscience, Careers in science Saturday, February 7, 2009 - 3:03pm

An interview with Dr. Michael McIntosh, who discovered the drug Prialt while working as an undergraduate in Dr. Olivera's lab.

Interview with Douglas Melton /biointeractive/interview-douglas-melton Interview Careers in science Tuesday, February 7, 2006 - 3:06pm

An interview with Dr. Melton.

Interview with Dr. Barbara Meyer /biointeractive/interview-dr-barbara-meyer Interview Careers in science Wednesday, February 7, 2001 - 3:09pm

A brief interview with Dr. Meyer.

Mice navigate a Barnes maze to test spatial learning /biointeractive/mice-navigate-barnes-maze-test-spatial-learning Clip Neuroscience, Behavior Thursday, February 7, 2008 - 3:12pm

Mice can be trained to use spatial cues to navigate a maze that tests their ability to remember specific locations.

Mouse Activity /biointeractive/mouse-activity Clip Behavior, Nutrition Saturday, February 7, 2004 - 3:14pm

Dr. Evans compares the activity of a normal mouse to one with a mutation in a key gene controlling obesity.

Mutant mice with crossed excitation hop /biointeractive/mutant-mice-crossed-excitation-hop Clip DNA, Neuroscience, Behavior Thursday, February 7, 2008 - 3:16pm

Kangaroo-like hopping when spinal cord excitatory interneurons cross the midline to stimulate both sides.

Microarrayer In Action /biointeractive/microarrayer-action Clip Genomics, Scientific methodology, Biotechnology Thursday, February 7, 2002 - 3:22pm

How a microarraying robot delivers hundreds of small molecules to a series of slides.

Interview with Olivier Mirabeau /biointeractive/interview-olivier-mirabeau Interview Careers in science Tuesday, February 7, 2006 - 3:24pm

An interview with Olivier Mirabeau, a scientist in Dr. Rosenthal's lab.

The Mosquito Life Cycle /biointeractive/mosquito-life-cycle Clip Virus, Behavior, Infectious disease Sunday, February 7, 2010 - 3:27pm

To prevent mosquitoes from spreading diseases, it's essential to understand their life cycle.

Mosquito Reggaeton, a Dengue Rap Song /biointeractive/mosquito-reggaeton-dengue-rap-song Clip Virus, Infectious disease, Science and society Sunday, February 7, 2010 - 3:29pm

Reggaeton, a popular Latin music form, rallies against dengue.

Mr. Lincoln Glows /biointeractive/mr-lincoln-glows Clip Chemistry Tuesday, February 7, 1995 - 4:19pm

Dr. Cech uses a penny and a beaker of acetone to illustrate how a catalyst works.

Interview with Mumna Al Banchaabouchi /biointeractive/interview-mumna-al-banchaabouchi Interview Careers in science Tuesday, February 7, 2006 - 4:21pm

An interview with Dr Mumna Al Banchaabouchi, researcher in the Mouse Phenotyping Core at EMBL in Monterotondo Italy.

Nicaragua and Sustainable Science /biointeractive/nicaragua-and-sustainable-science Scientists at Work Infectious disease, Science and society Sunday, February 7, 2010 - 4:24pm

Through the efforts of the Sustainable Sciences Institute, Nicaragua’s research capacity and disease-monitoring tools have improved dramatically.

Many Pathogens Affect Patients at a Nicaraguan Clinic /biointeractive/many-pathogens-affect-patients-nicaraguan-clinic Clip Infectious disease, Science and society Sunday, February 7, 2010 - 4:26pm

Many infectious diseases affect people in Nicaragua, and identifying the pathogens is surprisingly difficult.

Interview with Stephanie Nuñez /biointeractive/interview-stephanie-nu%C3%B1ez Interview Skin, muscles, and bones, Careers in science Monday, February 7, 2005 - 4:29pm

An interview with Stephanie Nuñez, a student in Dr. Kingsley's lab.

Interview with Tobi Ogbechie /biointeractive/interview-tobi-ogbechie Interview Careers in science Wednesday, February 7, 2007 - 4:38pm

An interview with Tobi Ogbechie, an undergraduate who discusses what it's like to be in a lab doing scientific research.

Interview with Bisola Ojikutu /biointeractive/interview-bisola-ojikutu Interview Careers in science Wednesday, February 7, 2007 - 4:40pm

An interview with Dr. Ojikutu.

Interview with Toto Olivera /biointeractive/interview-toto-olivera Interview Careers in science, Science and society Saturday, February 7, 2009 - 4:43pm

An interview with Dr. Olivera.

Interview with Dr. David Page /biointeractive/interview-dr-david-page Interview Careers in science Wednesday, February 7, 2001 - 4:45pm

A brief interview with Dr. Page.

Penicillin acting on bacteria /biointeractive/penicillin-acting-bacteria Clip Bacteria, Infectious disease Sunday, February 7, 1999 - 4:48pm

Penicillin, as shown in this video, causes the cell walls of bacteria to rupture.

Interview with Kristen Pepe /biointeractive/interview-kristen-pepe Interview Paleobiology, Careers in science Monday, February 7, 2011 - 6:05pm

Ms. Pepe talks about her experiences doing field work with the Shea lab as an undergraduate at Stony Brook University.

Philippines Biodiversity /biointeractive/philippines-biodiversity Clip Ecosystems, Communities, Biodiversity, Science and society Saturday, February 7, 2009 - 6:08pm

The Philippines archipelago is rich in marine biodiversity, including venomous octopus and venomous snails.

Demo: Phrenology /biointeractive/demo-phrenology Clip Neuroscience Thursday, February 7, 2008 - 6:10pm

Dr. Kandel illustrates the practice of the now-debunked theory of phrenology.

Pima Indians /biointeractive/pima-indians Clip Nutrition, Science and society Saturday, February 7, 2004 - 6:12pm

A clip about the Pima Indian tribe and how environment has affected them.

Interview with Shirly Pinto /biointeractive/interview-shirly-pinto Interview Careers in science Saturday, February 7, 2004 - 6:15pm

An interview with Shirly Pinto, a scientist in Dr. Friedman's lab.

Planarian Regeneration and Stem Cells /biointeractive/planarian-regeneration-and-stem-cells Scientists at Work Developmental biology, Stem cells Tuesday, February 7, 2006 - 6:17pm

A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.

Interview with Audra Pompeani /biointeractive/interview-audra-pompeani Interview Careers in science, Science and society Saturday, February 7, 2009 - 6:20pm

An interview with Dr. Audra Pompeani, a graduate student in Bonnie Bassler's lab.

Marathon Mouse /biointeractive/marathon-mouse Clip Behavior, Skin, muscles, and bones, Nutrition Saturday, February 7, 2004 - 6:23pm

Dr. Ronald Evans discusses the so-called "marathon" mouse, with a mutation in the PPAR-gamma gene, and its performance on a treadmill relative to a normal mouse.

Demo: Proprioception makes raising a mug easy /biointeractive/demo-proprioception-makes-raising-mug-easy Clip Neuroscience, Behavior Thursday, February 7, 2008 - 6:26pm

The average person has no difficulty raising a coffee mug.

Behavior of mice that lack proprioception /biointeractive/behavior-mice-lack-proprioception Clip Neuroscience, Behavior Thursday, February 7, 2008 - 6:28pm

Genetically engineered mice lacking proprioceptive sensory axons are not capable of well-coordinated walking.

Demonstration: Quorum sensing molecules /biointeractive/demonstration-quorum-sensing-molecules Clip Biochemistry, Bacteria, Cell signaling Saturday, February 7, 2009 - 6:31pm

Quorum sensing signal molecules have parts that are common between species as well as species-specific parts.

Interview with Harith Rajagopalan /biointeractive/interview-harith-rajagopalan Interview Careers in science Friday, February 7, 2003 - 6:34pm

An interview with Harith Rajagopalan, a scientist in Dr. Vogelstein's lab.

Interview with Priya Rajasethupathy /biointeractive/interview-priya-rajasethupathy Interview Careers in science Thursday, February 7, 2008 - 6:36pm

An interview with Priya Rajasethupathy, an MD/PhD student in Eric Kandel's lab.

Demo: Testing a student's proprioceptive reflex /biointeractive/demo-testing-students-proprioceptive-reflex Clip Skin, muscles, and bones, Neuroscience Thursday, February 7, 2008 - 6:38pm

A knee-jerk reflex depends on a simple circuit of proprioceptive sensory neurons and spinal motor neurons.

Enzymes That Are Not Proteins: The Discovery of Ribozymes /biointeractive/enzymes-are-not-proteins-discovery-ribozymes Clip Biochemistry, RNA Wednesday, February 8, 1995 - 11:47am

Listen to past HHMI President Dr. Thomas Cech discussing his Nobel Prize-winning discovery of RNA's catalytic properties.

Rift Valleys of Africa and Plate Tectonics /biointeractive/rift-valleys-africa-and-plate-tectonics Clip Paleobiology, Earth processes Tuesday, February 8, 2011 - 11:50am

African rift valleys were formed by the separation of tectonic plates. Water flows down to the valley floors, creating rivers and lakes.

Screening chemical libraries with robotics /biointeractive/screening-chemical-libraries-robotics Clip Chemistry, Biotechnology Sunday, February 8, 2009 - 11:52am

Robotic equipment makes it possible to screen massive chemical libraries in just a matter of days.

Interview with Dr. Michael Rosbash /biointeractive/interview-dr-michael-rosbash Interview Careers in science, Science and society Tuesday, February 8, 2000 - 11:54am

A brief interview with Dr. Rosbash.

Interview with Nadia Rosenthal /biointeractive/interview-nadia-rosenthal Interview Careers in science Wednesday, February 8, 2006 - 11:58am

An interview with Dr. Rosenthal.

South Africa: The "gogo" (grandmother) /biointeractive/south-africa-gogo-grandmother Clip Infectious disease, Science and society Thursday, February 8, 2007 - 12:00pm

When parents die of AIDS, the orphans often go to live with a "gogo," the Zulu word for grandmother.

South Africa: St. Mary's Hospital /biointeractive/south-africa-st-marys-hospital Clip Infectious disease, Science and society Thursday, February 8, 2007 - 12:02pm

How a South African hospital is coping with the HIV/AIDS epidemic and its many related healthcare issues.

South Africa: Traditional healers /biointeractive/south-africa-traditional-healers Clip Infectious disease, Science and society Thursday, February 8, 2007 - 12:04pm

Doctors hope to encourage healers to direct their patients to clinics for TB and AIDS-related diseases.

South Africa: Tuberculosis /biointeractive/south-africa-tuberculosis Clip Infectious disease, Science and society Thursday, February 8, 2007 - 12:05pm

A glimpse of the TB ward at a South African hospital, illustrating an illness associated with the AIDS epidemic.

South Africa: Umndeni "Family" Care Program /biointeractive/south-africa-umndeni-family-care-program Clip Infectious disease, Science and society Thursday, February 8, 2007 - 12:07pm

A program designed to provide health care and housing to South Africans living in poverty.

South Africa: WhizzKids /biointeractive/south-africa-whizzkids Clip Infectious disease, Science and society Thursday, February 8, 2007 - 12:09pm

Using soccer to teach children how to make important life choices and how to avoid HIV infection.

SCA1 Mouse on Rotarod /biointeractive/sca1-mouse-rotarod Clip Genetic basis of disease, Neuroscience, Behavior Saturday, February 8, 2003 - 12:11pm

Dr. Zoghbi demonstrates how mice that have been given the gene responsible for spinocerebellar ataxia 1 (SCA1) are tested on a device called a rotarod to quantify the amount of ataxia present.

Interview with Dr. Stuart Schreiber /biointeractive/interview-dr-stuart-schreiber Interview Careers in science Friday, February 8, 2002 - 12:13pm

An interview with Dr. Schreiber.

Somatic Cell Nuclear Transfer Video /biointeractive/somatic-cell-nuclear-transfer-video Clip Stem cells, Biotechnology Wednesday, February 8, 2006 - 12:15pm

Somatic cell nuclear transfer (SCNT) is performed looking through a microscope and using small glass pipettes to handle human eggs and to remove and transfer nuclei from one cell to another.

Interview with John Shea, PhD /biointeractive/interview-john-shea-phd Interview Paleobiology, Careers in science Tuesday, February 8, 2011 - 12:17pm

Dr. Shea discusses his early interest in anthropology, how field work has changed over the years, and his outside interests.

Demo: SHH concentration and eye position /biointeractive/demo-shh-concentration-and-eye-position Clip Developmental biology, Neuroscience, Cell signaling Friday, February 8, 2008 - 12:19pm

A reduction in the level of sonic hedgehog (SHH) gene expression can lead to cyclopia.

Size Analogies of Bacteria and Viruses /biointeractive/size-analogies-bacteria-and-viruses Clip Virus, Bacteria, Infectious disease Monday, February 8, 1999 - 12:20pm

Dr. Finlay and Dr. Richard Ganem use physical analogies to compare the size of bacteria and viruses relative to a standard mammalian cell.

Interview with Katherine Sorber /biointeractive/interview-katherine-sorber Interview Genomics, Infectious disease, Scientific methodology Monday, February 8, 2010 - 12:22pm

Katherine Sorber, a graduate student in the DeRisi lab, describes her research on malaria.

Demo: Using spatial memory to clear an obstacle /biointeractive/demo-using-spatial-memory-clear-obstacle Clip Neuroscience, Behavior Friday, February 8, 2008 - 12:26pm

Even without visual feedback, we are able to negotiate an obstacle using spatial memory.

Sperm Motility /biointeractive/sperm-motility Clip Reproduction, Developmental biology, Cell structure Thursday, February 8, 2001 - 12:28pm

Video microscopy of sperm motility in an average human male and an infertile male.

Spinocerebellar Ataxia Case Study /biointeractive/spinocerebellar-ataxia-case-study Clip Neuroscience, Skin, muscles, and bones Saturday, February 8, 2003 - 12:30pm

Dr. Huda Zoghbi interviews Milan Cloud, a patient who has inherited the neurological disorder spinocerebellar ataxia 1, or SCA1.

Stickleback Environment /biointeractive/stickleback-environment Clip Mechanisms of evolution, Paleobiology, Animals Tuesday, February 8, 2005 - 12:36pm

At the end of the ice age, the retreating ice sheet created many new lakes, some of which were colonized by sticklebacks.

Stickleback Fish on Jeopardy! /biointeractive/stickleback-fish-jeopardy Clip Animals, Science and society Tuesday, February 8, 2005 - 12:40pm

The identity of the stickleback fish stumps the contestants on the game show.

Stickleback Fossil Primer /biointeractive/stickleback-fossil-primer Scientists at Work Paleobiology, Scientific methodology Tuesday, February 8, 2005 - 12:43pm

A brief introduction to how stickleback fossils are collected and used to study evolution. It also shows the students who attended the 2005 Holiday Lectures taking part in a fossil-collecting activity.

Classifying Stone Tools /biointeractive/classifying-stone-tools Clip Paleobiology, Human evolution Tuesday, February 8, 2011 - 12:44pm

Prehistoric stone tools are classified into six broad technological modes by the level of sophistication and method of fabrication.

Stratigraphic Principles /biointeractive/stratigraphic-principles Clip Paleobiology, Geology, Earth processes, Scientific methodology Tuesday, February 8, 2011 - 12:46pm

Dr. John Shea demonstrates the two main principles in the study of rock layers: superposition and association.

Interview with Lee Swem /biointeractive/interview-lee-swem Interview Careers in science Sunday, February 8, 2009 - 12:47pm

An interview with Dr. Lee Swem, a post-doctoral fellow in Bonnie Bassler's lab.

Symptoms of acute HIV infection /biointeractive/symptoms-acute-hiv-infection Clip Virus, Infectious disease Thursday, February 8, 2007 - 12:49pm

Adam Barrett remembers his symptoms of acute HIV infection.

Interview with Dr. Joseph Takahashi /biointeractive/interview-dr-joseph-takahashi Interview Behavior, Careers in science Tuesday, February 8, 2000 - 12:51pm

A brief interview with Dr. Takahashi.

A Taser causes rigid paralysis /biointeractive/taser-causes-rigid-paralysis Clip Skin, muscles, and bones, Neuroscience Sunday, February 8, 2009 - 12:52pm

A Taser hyperexcites the nervous system to cause a rigid immobilization of its target.

Transmission of Disease on an Airplane /biointeractive/transmission-disease-airplane Clip Infectious disease, Scientific methodology Monday, February 8, 1999 - 12:54pm

Dr. Finlay, using his student audience, gives a live demonstration of how an antibiotic-resistant strain of tuberculosis managed to spread through the passengers on an airplane.

Demo: Touching thumb to fingers with proprioception /biointeractive/demo-touching-thumb-fingers-proprioception Clip Skin, muscles, and bones, Neuroscience Friday, February 8, 2008 - 12:56pm

Proprioceptive feedback makes it easy to touch one's thumb to one's fingers without looking.

Human Circadian Activity /biointeractive/human-circadian-activity Clip Behavior Tuesday, February 8, 2000 - 12:58pm

This time-lapse videoclip shows human circadian activity while assembling a T. rex skeleton.

Mouse Circadian Activity /biointeractive/mouse-circadian-activity Clip Behavior Tuesday, February 8, 2000 - 1:01pm

This time-lapse videoclip illustrates a mouse's nocturnal behavior.

Interview with Sarah Tishkoff, PhD /biointeractive/interview-sarah-tishkoff-phd Interview Careers in science, Scientific methodology Tuesday, February 8, 2011 - 1:03pm

Dr. Tishkoff explains how studying genetic diversity can shed light on modern-day diseases, such as diabetes and obesity.

Learning from Mice: The Science of Transgenic Technology /biointeractive/learning-mice-science-transgenic-technology Clip DNA, Scientific methodology, Biotechnology Saturday, February 8, 2003 - 1:05pm

What do humans, flies, and worms have in common? More than you might think. See how transgenic organisms are engineered, and how they enable researchers to study genetic diseases.

Deep nets to harvest Turrids /biointeractive/deep-nets-harvest-turrids Clip Biodiversity Sunday, February 8, 2009 - 1:06pm

Fishermen harvest deep-sea species of venomous snails by retrieving a net that had been deployed months ago.

DNA Gene Chip Explanation /biointeractive/dna-gene-chip-explanation Clip Bioinformatics, Biotechnology Wednesday, February 8, 2006 - 1:08pm

Dr. Melton describes the process used to extract DNA from a cell and to analyze it on a gene chip.

Mosquito Vector Education Program in Nicaragua /biointeractive/mosquito-vector-education-program-nicaragua Clip Infectious disease, Science and society Monday, February 8, 2010 - 1:10pm

The Nicaraguan grassroots program teaches mosquito control methods to curb dengue fever epidemics.

Cone Snails: Versatile Hunters /biointeractive/cone-snails-versatile-hunters Clip Biodiversity, Animals, Neuroscience, Behavior Sunday, February 8, 2009 - 1:12pm

Dr. Jason Biggs of the University of Guam Marine Laboratory discusses the anatomy of cone snails and introduces us to a variety of cone snail species with different tactics to hunt and capture their prey.

Vacuuming Mosquitoes /biointeractive/vacuuming-mosquitoes Interview Infectious disease, Careers in science, Scientific methodology Monday, February 8, 2010 - 1:13pm

Ben Vincent describes his summer work collecting mosquitoes for Dr. Marm Kilpatrick's research on the ecology and epidemiology of the West Nile virus.

Virulence Injection Simulation /biointeractive/virulence-injection-simulation Clip Bacteria, Infectious disease Monday, February 8, 1999 - 1:15pm

Using a bagel, a syringe, and blue dye to illustrate how some virulent strains of bacteria inject virulence factors into a cell.

Visualizing learning /biointeractive/visualizing-learning Clip Neuroscience, Behavior, Cell signaling, Scientific methodology Friday, February 8, 2008 - 1:16pm

Dr. Harshad Vishwasrao guides you through a collection of images showing neuronal growth and synaptic formation representative of anatomical changes that occur during learning.

Interview with Dr. Bert Vogelstein /biointeractive/interview-dr-bert-vogelstein Interview Careers in science Saturday, February 8, 2003 - 1:18pm

An interview with Dr. Vogelstein.

Interview with Bruce Walker /biointeractive/interview-bruce-walker Interview Careers in science, Science and society Thursday, February 8, 2007 - 1:19pm

An interview with Dr. Walker.

Walking versus hopping /biointeractive/walking-versus-hopping Clip Skin, muscles, and bones, Neuroscience, Behavior Friday, February 8, 2008 - 1:21pm

In a giraffe's walk, left and right limbs move alternately, while in a kangaroo's hop, opposing limbs move together.

Waterman touching thumb to fingers without feedback /biointeractive/waterman-touching-thumb-fingers-without-feedback Clip Neuroscience, Behavior Friday, February 8, 2008 - 1:24pm

In the absence of proprioception and visual feedback, it is impossible to touch thumb to fingers accurately.

Clive Wearing plays piano despite memory deficit /biointeractive/clive-wearing-plays-piano-despite-memory-deficit Clip Neuroscience Friday, February 8, 2008 - 1:26pm

Even though Clive Wearing cannot remember people or events, his piano-playing skills are intact.

Clive Wearing: A man without memory /biointeractive/clive-wearing-man-without-memory Clip Neuroscience, Behavior Friday, February 8, 2008 - 1:28pm

Clive Wearing has lost his ability to remember and lives in a perpetual state of having just awoken.

Interview with Tim White, PhD /biointeractive/interview-tim-white-phd Interview Careers in science, Science and society Tuesday, February 8, 2011 - 1:30pm

Dr. White talks about his passion both for his fieldwork and for educating the scientists of tomorrow.

Interview with Kate Williams /biointeractive/interview-kate-williams Interview Careers in science, Science and society Monday, February 8, 2010 - 1:31pm

Kate Williams, a graduate student in the Harris lab, describes her epidemiological research linking antibodies and severe dengue in Nicaragua.

Without proprioception, raising a mug is difficult /biointeractive/without-proprioception-raising-mug-difficult Clip Skin, muscles, and bones, Neuroscience Friday, February 8, 2008 - 1:33pm

A person with a disease that kills proprioceptive neurons has severe problems with the simplest of movements.

Interview with Nathan Yozwiak /biointeractive/interview-nathan-yozwiak Interview Careers in science, Science and society Monday, February 8, 2010 - 1:34pm

Nathan Yozwiak, a graduate student in the Harris/DeRisi labs, discusses working in Nicaragua to discover a new virus infecting children.

Interview with Dr. Laskaro Zagoraiou /biointeractive/interview-dr-laskaro-zagoraiou Interview Neuroscience, Science and society Friday, February 8, 2008 - 1:36pm

An interview with Dr. Laskaro Zagoraiou, a post-doctoral student in Thomas Jessell's lab.

Interview with Katie Walter /biointeractive/interview-katie-walter Interview Immunology, Infectious disease, Careers in science Thursday, February 8, 2007 - 1:37pm

An interview with Katie Walter, an undergraduate who discusses what it's like to be in a lab doing scientific research.

Bones, Stones, and Genes: The Origin of Modern Humans /biointeractive/bones-stones-and-genes-origin-modern-humans Lecture Paleobiology, Human evolution, Gene regulation, History of science, Scientific methodology Saturday, February 19, 2011 - 3:33pm

Where and when did humans arise? What distinguishes us from other species? Did our distant ancestors look and behave like us?

Human Evolution and the Nature of Science /biointeractive/human-evolution-and-nature-science Lecture Paleobiology, Human evolution, Scientific methodology Saturday, February 19, 2011 - 3:36pm

How reasoning and evidence are used to understand human evolution.

Genetics of Human Origins and Adaptation /biointeractive/genetics-human-origins-and-adaptation Lecture Human evolution, DNA, Gene regulation, Genomics Sunday, February 20, 2011 - 2:02pm

Genetic evidence shows that humans evolved in Africa and continue to evolve.

Stone Tools and the Evolution of Human Behavior /biointeractive/stone-tools-and-evolution-human-behavior Lecture Paleobiology, Human evolution, Scientific methodology Sunday, February 20, 2011 - 2:16pm

Stone tools are well-preserved evidence of past human activity.

Hominid Paleobiology /biointeractive/hominid-paleobiology Lecture Paleobiology, Human evolution, Skin, muscles, and bones, Scientific methodology Sunday, February 20, 2011 - 2:23pm

The hominid fossil record of the past six million years gives us surprising insights into the path of human evolution.

Genetics of Bitter Taste Perception /biointeractive/genetics-bitter-taste-perception Lecture Human evolution, Mendelian inheritance, Neuroscience, Careers in science Sunday, February 20, 2011 - 2:29pm

How humans perceive bitter taste, and the evolution of taste perception.

Reporting Scientific Results to the Public /biointeractive/reporting-scientific-results-public Lecture Science and society Sunday, February 20, 2011 - 2:33pm

Second discussion in the 2011 Holiday Lectures on human evolution, on how to effectively report scientific results to the general public.

Evolution: Constant Change and Common Threads /biointeractive/evolution-constant-change-and-common-threads Lecture Evolutionary theory, Mechanisms of evolution, Paleobiology, Gene regulation, History of science, Scientific methodology Sunday, February 20, 2005 - 2:43pm

How has the amazing diversity of plants and animals evolved? What can fossils, butterflies, and stickleback fish tell us about the deep common ancestry of all living forms?

Endless Forms Most Beautiful /biointeractive/endless-forms-most-beautiful Lecture Evolutionary theory, Paleobiology, History of science Sunday, February 20, 2005 - 2:55pm

How Darwin came to publish The Origin of Species, and examples of how quickly evolution can change a population.

Selection in Action /biointeractive/selection-action Lecture Mechanisms of evolution, Natural selection, Artificial selection, Gene regulation, Skin, muscles, and bones Sunday, February 20, 2005 - 3:14pm

Comparing the artificial selection of dogs and corn with the natural selection of the stickleback fish.

Fossils, Genes, and Embryos /biointeractive/fossils-genes-and-embryos Lecture Evolutionary theory, Paleobiology, Mechanisms of evolution, Gene regulation, Skin, muscles, and bones Sunday, February 20, 2005 - 3:19pm

The genetic mechanisms by which evolution occurs, and an overview of the evidence for evolutionary theory.

From Butterflies to Humans /biointeractive/butterflies-humans Lecture Paleobiology, Mechanisms of evolution, Animals, Gene regulation Sunday, February 20, 2005 - 3:29pm

How and why butterflies and fruit flies got their spots, and the fossil record for human evolution.

Reconciling Religion and Science /biointeractive/reconciling-religion-and-science Lecture Evolutionary theory, Science and society Sunday, February 20, 2005 - 4:04pm

A discussion on reconciling religion and science with students, the lecturers, and guest speakers.

Evolution: Fossils, Genes, and Mousetraps /biointeractive/evolution-fossils-genes-and-mousetraps Lecture Evolutionary theory, Paleobiology, Science and society, Scientific methodology Monday, February 20, 2006 - 4:12pm

Leading evolution educator Ken Miller discusses the controversy surrounding the teaching of evolution.

Fossils, Genes, and Mousetraps /biointeractive/fossils-genes-and-mousetraps Lecture Evolutionary theory, Paleobiology, Mechanisms of evolution, Science and society Monday, February 20, 2006 - 4:17pm

Leading evolution educator Ken Miller discusses the controversy surrounding the teaching of evolution.

Viral Outbreak: The Science of Emerging Disease /biointeractive/viral-outbreak-science-emerging-disease Lecture Virus, DNA, Bioinformatics, Immunology, Infectious disease, Biotechnology Saturday, February 20, 2010 - 4:47pm

Watch two leading virus researchers explain how they use both simple and sophisticated technologies to detect and fight infectious agents.

Dengue Fever: Breaking Epidemic Cycles /biointeractive/dengue-fever-breaking-epidemic-cycles Lecture Virus, Infectious disease, Science and society Saturday, February 20, 2010 - 4:53pm

Learn about research aimed at thwarting dengue fever in the lab and in communities.

The Virus Hunter's Toolkit /biointeractive/virus-hunters-toolkit Lecture Virus, DNA, Genomics, Bioinformatics, Infectious disease, Biotechnology Saturday, February 20, 2010 - 4:59pm

New technologies like the Virochip harness DNA's properties to identify and fight new viruses.

Fighting Viruses in the Lab and Beyond /biointeractive/fighting-viruses-lab-and-beyond Lecture Immunology, Infectious disease, Science and society, Biotechnology Saturday, February 20, 2010 - 5:05pm

Understanding the immune response is essential to developing safe vaccines for dengue and other diseases.

Solving SARS and Other Viral Mysteries /biointeractive/solving-sars-and-other-viral-mysteries Lecture Virus, Genomics, Bioinformatics, Infectious disease, Biotechnology Saturday, February 20, 2010 - 5:12pm

The SARS epidemic was successfully halted by a global research effort to identify a new virus.

Biology of the Mosquito Vector /biointeractive/biology-mosquito-vector Lecture Virus, Infectious disease, Biotechnology Saturday, February 20, 2010 - 5:15pm

This discussion from the 2010 Holiday Lectures on Science explores the ethics of genetically-modified organisms and other topics.

AIDS: Evolution of an Epidemic /biointeractive/aids-evolution-epidemic Lecture Virus, Immunology, Infectious disease, Cell signaling, Science and society Wednesday, February 21, 2007 - 10:42am

Why has it been so hard to develop a vaccine against HIV? How are new medicines revolutionizing AIDS treatment? Can AIDS be cured?

From Outbreak to Epidemic /biointeractive/outbreak-epidemic Lecture Virus, Immunology, Infectious disease, History of science Wednesday, February 21, 2007 - 10:54am

The genesis of AIDS, identifying HIV as the virus that causes AIDS, and the modern global epidemic.

AIDS and the HIV Life Cycle /biointeractive/aids-and-hiv-life-cycle Lecture Virus, Immunology, Infectious disease, Cell signaling Wednesday, February 21, 2007 - 10:59am

The HIV life cycle, and how the virus destroys the immune system's ability to respond to infection.

Drugs and HIV Evolution /biointeractive/drugs-and-hiv-evolution Lecture Virus, Infectious disease, Science and society Wednesday, February 21, 2007 - 11:05am

Treating HIV infection with antiretroviral therapy, and HIV's ability to develop drug resistance.

Vaccines and HIV Evolution /biointeractive/vaccines-and-hiv-evolution Lecture Mechanisms of evolution, Immunology, Infectious disease, Science and society Wednesday, February 21, 2007 - 11:13am

The search for an effective HIV vaccine, and advances in genomics that may lead to a breakthrough.

Students Fighting the HIV Epidemic /biointeractive/students-fighting-hiv-epidemic Lecture Virus, Infectious disease, Careers in science, Science and society Wednesday, February 21, 2007 - 11:17am

A discussion with three students who are helping in the global fight against HIV and AIDS.

Discussion: Living with HIV /biointeractive/discussion-living-hiv Lecture Infectious disease, Science and society Wednesday, February 21, 2007 - 11:23am

Three HIV-positive individuals share their personal experiences about living with HIV.

2000 and Beyond: Confronting the Microbe Menace /biointeractive/2000-and-beyond-confronting-microbe-menace Lecture Virus, Bacteria, Immunology, Infectious disease, Cell signaling Sunday, February 21, 1999 - 11:56am

In four presentations, Donald E. Ganem, MD, and B. Brett Finlay, PhD, discuss the latest advances in understanding how pathogens invade the body and how this knowledge is leading to the development of new therapies. They also explain how new infectious diseases are recognized and how epidemics arise.

Microbe Hunters: Tracking Infectious Agents /biointeractive/microbe-hunters-tracking-infectious-agents Lecture Virus, Infectious disease, History of science, Scientific methodology Sunday, February 21, 1999 - 12:05pm

Dr. Donald Ganem describes how epidemiologists, physicians, and microbiologists work together to identify and study pathogens.

The Microbes Strike Back /biointeractive/microbes-strike-back Lecture Bacteria, Genomics, Infectious disease Sunday, February 21, 1999 - 12:08pm

Dr. Brett Finlay explains why bacterial diseases continue to be a major health problem worldwide, causing a third of the world's deaths every year.

Outwitting Bacteria's Wily Ways /biointeractive/outwitting-bacterias-wily-ways Lecture Bacteria, Infectious disease, Cell signaling Sunday, February 21, 1999 - 12:11pm

Dr. Finlay showcases three types of bacteria to illustrate how molecular biology is allowing researchers to probe the molecular workings of bacterial infections.

Emerging Infections: How Epidemics Arise /biointeractive/emerging-infections-how-epidemics-arise Lecture Mechanisms of evolution, Virus, DNA, Infectious disease Sunday, February 21, 1999 - 12:14pm

Dr. Ganem analyses the complex causes of epidemics—how changes in the environment and in human social behavior can give rise to new infectious diseases.

Exploring Biodiversity: The Search for New Medicines /biointeractive/exploring-biodiversity-search-new-medicines Lecture Biodiversity, Bacteria, Skin, muscles, and bones, Neuroscience, Cell signaling Saturday, February 21, 2009 - 1:52pm

What medical secrets do venomous snails hold? How can listening in on bacterial conversations help develop new antibiotics? In four presentations, Dr. Bonnie L. Bassler and Dr. Baldomero M. Olivera reveal how a deeper understanding of nature and biodiversity informs their research into new medicines.

From Venoms to Drugs /biointeractive/venoms-drugs Lecture Biodiversity, Neuroscience, Behavior, Cell signaling Saturday, February 21, 2009 - 1:54pm

Venomous carniverous cone snails are a rich source of molecules for scientific research and potential drug development.

Shedding Light on an Invisible World /biointeractive/shedding-light-invisible-world Lecture Biodiversity, Bacteria, Cell signaling Saturday, February 21, 2009 - 1:57pm

Bacteria are capable of communicating and coordinating their activities with a molecular signaling system called quorum sensing.

Biodiversity at a Snail's Pace /biointeractive/biodiversity-snails-pace Lecture Biodiversity, Proteins, Skin, muscles, and bones, Neuroscience, Cell signaling Saturday, February 21, 2009 - 1:59pm

Cone snails have evolved many different toxins for different uses. Total molecular biodiversity may number in the millions.

Eavesdropping on Tiny Conspiracies /biointeractive/eavesdropping-tiny-conspiracies Lecture Biodiversity, Biochemistry, Bacteria, Cell signaling Saturday, February 21, 2009 - 2:02pm

The quorum sensing system is a target for a new class of drugs that interfere with virulence without killing bacteria.

Biodiversity Discussion /biointeractive/biodiversity-discussion Lecture Biodiversity, Human impacts, Science and society Saturday, February 21, 2009 - 2:08pm

A discussion on biodiversity, endangered habitats, and how best to preserve the Earth's ecosystems, presented by the lecturers along with Dr. E.O. Wilson and Dr. Eric Chivian.

Q&A on Quorum Sensing /biointeractive/qa-quorum-sensing Lecture Bacteria, Cell signaling Saturday, February 21, 2009 - 2:11pm

In this 13-minute Q&A session, Dr. Bonnie Bassler answers questions on quorum sensing and other topics related to bacteria.

Q&A on Cone Snails /biointeractive/qa-cone-snails Lecture Biodiversity, Neuroscience, Behavior Saturday, February 21, 2009 - 2:13pm

In this ten-minute Q&A session, Dr. Olivera answers questions on cone snail behavior, venoms, and biodiversity.

Making Your Mind: Molecules, Motion, and Memory /biointeractive/making-your-mind-molecules-motion-and-memory Lecture Neuroscience, Behavior, History of science Thursday, February 21, 2008 - 2:29pm

What is mind? Can molecular biology help us understand mental function?

Mapping Memory in the Brain /biointeractive/mapping-memory-brain Lecture Neuroscience, Behavior, History of science Thursday, February 21, 2008 - 2:33pm

The history of localization of function in the brain, and research that led to the understanding of localization of memory.

Building Brains: The Molecular Logic of Neural Circuits /biointeractive/building-brains-molecular-logic-neural-circuits Lecture Developmental biology, Neuroscience, Cell signaling Thursday, February 21, 2008 - 2:36pm

How a nerve cell gets its identity, sends axons, and makes connections with other cells.

Plan of Action: How the Spinal Cord Controls Movement /biointeractive/plan-action-how-spinal-cord-controls-movement Lecture Skin, muscles, and bones, Neuroscience, Behavior, Cell signaling Thursday, February 21, 2008 - 2:38pm

Understanding the neural circuits in the spinal cord that control movement.

Memories are Made of This /biointeractive/memories-are-made Lecture Neuroscience, Behavior, Cell signaling Thursday, February 21, 2008 - 2:42pm

The cellular and molecular nature of learning and memory, investigated in simpler sea slugs and more-complex mice. Molecular basis of Alzheimer's disease.

Neurobiology and Mental Illness /biointeractive/neurobiology-and-mental-illness Lecture Neuroscience Thursday, February 21, 2008 - 2:44pm

The lecturers, joined by Dr. Kay Jamison of the Johns Hopkins University School of Medicine and Dr. Gerald Fischbach of the Simons Foundation, answer questions concerning autism, manic depression, and other mental illnesses.

Learning from Patients: The Science of Medicine /biointeractive/learning-patients-science-medicine Lecture Genetic basis of disease, Neuroscience, Cancer Friday, February 21, 2003 - 2:59pm

As part of the 2003 Holiday Lectures on Science, Dr. Bert Vogelstein and Dr. Huda Y. Zoghbi discuss how their patients have led to a deeper understanding of the genetic and molecular bases of neurological disorders and cancer. Thanks to these patients, researchers can now apply the knowledge gained to diagnosis, prevention, and the search for cures.

Research Mechanics: Putting the Brakes on Cancer /biointeractive/research-mechanics-putting-brakes-cancer Lecture Genetic basis of disease, DNA, Cancer Friday, February 21, 2003 - 3:11pm

Although there are numerous kinds of cancer, all stem from alterations that allow cell division to outstrip cell demise.

Chaos to Cure: Bringing Basic Research to Patients /biointeractive/chaos-cure-bringing-basic-research-patients Lecture Genetic basis of disease, Cancer, Biotechnology Friday, February 21, 2003 - 3:13pm

The identification of hundreds of genes involved in the formation and spread of cancer is leading to promising new methods for diagnosis, prevention, and treatment.

A Healthy Nervous System: A Delicate Balance /biointeractive/healthy-nervous-system-delicate-balance Lecture Proteins, Mendelian inheritance, Genetic basis of disease, Neuroscience, Cell signaling Friday, February 21, 2003 - 3:18pm

Mutations in key genes can lay waste to the nervous system. By studying large families predisposed to developing these genetic disorders, scientists can identify the responsible altered gene.

The Strength of Families: Solving Rett Syndrome /biointeractive/strength-families-solving-rett-syndrome Lecture Genetic basis of disease, Gene regulation, Neuroscience, Cell growth and division Friday, February 21, 2003 - 3:20pm

Girls with Rett syndrome develop normally for about 18 months and then begin to regress. With the help of affected girls and their families, Dr. Zoghbi and her collaborators searched for the gene responsible for this neurological disorder.

Bioethics Discussion /biointeractive/bioethics-discussion Lecture Genomics, Science and society Friday, February 21, 2003 - 3:23pm

Genetic research benefits health, but also raises thorny ethical issues.

Senses and Sensitivity: Neuronal Alliances for Sight and Sound /biointeractive/senses-and-sensitivity-neuronal-alliances-sight-and-sound Lecture Genetic basis of disease, Neuroscience, Cell signaling Saturday, February 22, 1997 - 10:51am

In four talks, A. James Hudspeth, MD, PhD, and Jeremy H. Nathans, MD, PhD, discuss how sensory information is encoded and transmitted to the brain. They describe the detailed workings of two senses of great importance to humans—vision and hearing.

Sensory Transduction: Getting the Message /biointeractive/sensory-transduction-getting-message Lecture Neuroscience, Cell signaling Saturday, February 22, 1997 - 10:57am

Dr. Hudspeth will begin by discussing how simple organisms—such as bacteria—have the capacity to detect and react to a stimulus.

The Science of Sight: Getting the Picture /biointeractive/science-sight-getting-picture Lecture Neuroscience, Cell signaling Saturday, February 22, 1997 - 10:59am

Dr. Nathans will discuss how the visual process involves the detection of light by photo-receptors in the retina.

The Science of Sound: How Hearing Happens /biointeractive/science-sound-how-hearing-happens Lecture Neuroscience, Cell signaling Saturday, February 22, 1997 - 11:03am

Dr. Hudspeth will explain the basis for the ear’s remarkable ability to detect sound through the hair cell, the sensory receptor found in the inner ear.

Neural Processing: Making Sense of Sensory Information /biointeractive/neural-processing-making-sense-sensory-information Lecture Neuroscience, Cell signaling Saturday, February 22, 1997 - 11:07am

Dr. Nathans will complete the lecture series by clarifying what is known about the brain’s ability to process and integrate various elements of the visual system, such as color, motion, and depth.

Potent Biology: Stem Cells, Cloning, and Regeneration /biointeractive/potent-biology-stem-cells-cloning-and-regeneration Lecture Developmental biology, Stem cells Wednesday, February 22, 2006 - 11:15am

Doug Melton and Nadia Rosenthal are leaders in stem cell research, working primarily with mouse and human tissue. They will discuss where embryonic and adult stem cells come from and the biology of how they supply the cells the body needs.

Understanding Embryonic Stem Cells /biointeractive/understanding-embryonic-stem-cells Lecture Gene expression, Developmental biology, Stem cells, Biotechnology Wednesday, February 22, 2006 - 11:21am

An overview of embryonic development, the progressive differentiation of cells, and properties of embryonic stem cells.

Adult Stem Cells and Regeneration /biointeractive/adult-stem-cells-and-regeneration Lecture Stem cells, Cell growth and division Wednesday, February 22, 2006 - 11:24am

The role of stem cells in regeneration, and ongoing research to improve mammalian regeneration potency.

Coaxing Embryonic Stem Cells /biointeractive/coaxing-embryonic-stem-cells Lecture Developmental biology, Stem cells, Biotechnology Wednesday, February 22, 2006 - 11:30am

In cloning, a cell's genetic machinery is reprogrammed. Can we similarly coax stem cells to become specific cell types?

Stem Cells and the End of Aging /biointeractive/stem-cells-and-end-aging Lecture Skin, muscles, and bones, Stem cells, Cell growth and division, Cell signaling Wednesday, February 22, 2006 - 11:39am

Finding factors to reverse age-related loss of cell maintenance, and some examples of stem cell therapies.

Stem Cell Research: Policies and Ethics /biointeractive/stem-cell-research-policies-and-ethics Lecture Stem cells, Science and society Wednesday, February 22, 2006 - 11:41am

A discussion on policies and ethical issues associated with stem cell research.

The Science of Fat /biointeractive/science-fat Lecture Nutrition, Neuroscience, Behavior, Cell signaling Wednesday, February 25, 2004 - 11:15am

In the 2004 Holiday Lectures on Science, HHMI investigators Ronald M. Evans and Jeffrey M. Friedman discuss how the body regulates weight by carefully controlling the storage and burning of fat—and how a better understanding of these complex metabolic systems could lead researchers to treatments that curb obesity and improve public health.

Awards

  • 2006 Telly Awards; Silver

Deconstructing Obesity /biointeractive/deconstructing-obesity Lecture Genetic basis of disease, Behavior, Nutrition Wednesday, February 25, 2004 - 11:19am

Dr. Friedman introduces the genes and circuits that control appetite, including the key role of leptin.

Understanding Fat: Syndrome X and Beyond /biointeractive/understanding-fat-syndrome-x-and-beyond Lecture Behavior, Nutrition, Cell signaling Wednesday, February 25, 2004 - 11:23am

Dr. Evans describes how fat communicates with muscle and how diet and exercise influence that relationship.

Balancing the Fat Equation /biointeractive/balancing-fat-equation Lecture Gene regulation, Nutrition, Cell signaling Wednesday, February 25, 2004 - 11:25am

Dr. Evans reviews how PPARs regulate body weight by controlling whether fat is burned or stored.

Exploring Obesity: From the Depths of the Brain to the Far Pacific /biointeractive/exploring-obesity-depths-brain-far-pacific Lecture Genomics, Genetic basis of disease, Neuroscience, Nutrition Wednesday, February 25, 2004 - 11:42am

Dr. Friedman shows how leptin rewires neural circuits, and how population studies may identify obesity genes.

Student Discussion Session on Obesity /biointeractive/student-discussion-session-obesity Lecture Nutrition, Cell signaling, Science and society Wednesday, February 25, 2004 - 11:46am

A Q&A session on obesity and related issues, with the lecturers and students attending the Holiday Lectures on Science.

Scanning Life's Matrix: Genes, Proteins, and Small Molecules /biointeractive/scanning-lifes-matrix-genes-proteins-and-small-molecules Lecture Chemistry, DNA, Genomics, Biotechnology Monday, February 25, 2002 - 12:28pm

In four presentations, Stuart L. Schreiber, PhD, and Eric S. Lander, PhD, open a window onto the fast-paced world of genomic science and chemical genetics.

Reading Genes and Genomes /biointeractive/reading-genes-and-genomes Lecture Genomics, Bioinformatics, DNA, Biotechnology Monday, February 25, 2002 - 12:34pm

Dr. Eric Lander takes us on a tour of this remarkable genetic century, describing the rapid advances in DNA sequencing technologies and information science.

Probing Genes and Genomes /biointeractive/probing-genes-and-genomes Lecture Chemistry, Proteins, Genomics, Biotechnology Monday, February 25, 2002 - 12:36pm

To understand life's processes, perturb them. How a process responds to an insult can provide clues about normal function or mimic a specific disease state.

Human Genomics: A New Guide for Medicine /biointeractive/human-genomics-new-guide-medicine Lecture Genomics, Bioinformatics, DNA, Biotechnology Monday, February 25, 2002 - 12:38pm

Dr. Lander explores human genetic variation and how it may affect individual susceptibility to certain diseases.

Chemical Genomics: New Tools for Medicine /biointeractive/chemical-genomics-new-tools-medicine Lecture Chemistry, Proteins, Genomics, Bioinformatics, Biotechnology Monday, February 25, 2002 - 12:41pm

Scientists now have the ability to create millions of new molecules. How do they test whether any of these molecules are useful?

Discussion Session: Teacher discussion /biointeractive/discussion-session-teacher-discussion Lecture Genomics, Careers in science Monday, February 25, 2002 - 12:43pm

A wide-ranging 45-minute discussion between Dr. Eric Lander, Dr. Stuart Schreiber, and four Washington DC-area high school teachers.

The Meaning of Sex: Genes and Gender /biointeractive/meaning-sex-genes-and-gender Lecture Mechanisms of evolution, Gene regulation, Reproduction, Cell signaling Sunday, February 25, 2001 - 1:08pm

Four talks focus on sex determination—the molecular and genetic mechanisms that determine whether an organism will be male, female or a hermaphrodite.

Deciphering the Language of Sex /biointeractive/deciphering-language-sex Lecture DNA, Reproduction, Developmental biology Sunday, February 25, 2001 - 1:11pm

Is it a boy or a girl? Dr. David Page looks at how we define male and female and summarizes the development of human sex characteristics.

Hermaphrodites: The Safer Sex /biointeractive/hermaphrodites-safer-sex Lecture Gene expression, Gene regulation, Reproduction, Cell signaling Sunday, February 25, 2001 - 1:13pm

Dr. Barbara Meyer explains the value of studying model organisms and introduces the nematode C. elegans.

Sex and Death: Too Much of a Good Thing /biointeractive/sex-and-death-too-much-good-thing Lecture Gene expression, Gene regulation, Reproduction, Cell growth and division Sunday, February 25, 2001 - 1:15pm

Having too many chromosomes can lead to too much gene expression. Dr. Meyer explains how the gene that controls dosage compensation in C. elegans works.

Sexual Evolution: From X to Y /biointeractive/sexual-evolution-x-y Lecture Mechanisms of evolution, DNA, Reproduction, Biotechnology Sunday, February 25, 2001 - 1:30pm

Dr. Page explains how successive inversions and deletions of the Y chromosome during mammalian evolution have reduced it to its present form—small and sparsely populated with genes.

Clockwork Genes: Discoveries in Biological Time /biointeractive/clockwork-genes-discoveries-biological-time Lecture Gene expression, Gene regulation, Neuroscience, Behavior, Cell signaling Friday, February 25, 2000 - 1:48pm

Four lectures highlight the research of two scientists who have made groundbreaking discoveries elucidating the molecular basis of circadian clocks—the internal timekeepers that govern fluctuations in behavior and physiology on a 24-hour cycle.

Biology in Four Dimensions /biointeractive/biology-four-dimensions Lecture Neuroscience, Behavior Friday, February 25, 2000 - 1:55pm

Dr. Joseph Takahashi takes us on an exciting journey into a very special region of the brain—the biological clock that governs our physiology and certain behaviors.

Unwinding Clock Genetics /biointeractive/unwinding-clock-genetics Lecture Gene expression, Behavior, Biotechnology Friday, February 25, 2000 - 1:57pm

Although tiny in size, the fruit fly has had a major impact on our understanding of circadian rhythms.

PERfect TIMing /biointeractive/perfect-timing Lecture Gene expression, Behavior, Biotechnology Friday, February 25, 2000 - 2:00pm

Dr. Rosbash discloses how scientists have persuaded Mother Nature to reveal the inner workings of the fruit fly's biological clock.

The Mammalian Timekeeper /biointeractive/mammalian-timekeeper Lecture Biodiversity, Gene expression, Behavior Friday, February 25, 2000 - 2:02pm

Dr. Takahashi describes the powerful strategies that he and others have harnessed for understanding biological clocks in mammals.

Of Hearts and Hypertension: Blazing Genetic Trails /biointeractive/hearts-and-hypertension-blazing-genetic-trails Lecture Genetic basis of disease, Circulation Wednesday, February 25, 1998 - 2:45pm

In four lectures, Richard P. Lifton, MD, PhD, and Christine E. Seidman, MD, discuss their groundbreaking work in using genetic and molecular approaches to understand cardiovascular diseases.

Brave Heart: Circle of Life /biointeractive/brave-heart-circle-life Lecture Circulation Wednesday, February 25, 1998 - 2:51pm

The heart acts as a dual pump, sending oxygen-depleted blood to the lungs to be reinvigorated and pumping oxygen-rich blood to vital organs throughout the body.

Telltale Genes: Charting Human Disease /biointeractive/telltale-genes-charting-human-disease Lecture Genetic basis of disease, Circulation Wednesday, February 25, 1998 - 2:53pm

The discovery of DNA as the basis of heredity led to an explosive growth of knowledge about the human genome and allowed the identification of genes that predispose people to different diseases.

Heartbreak: Of Mutations and Maladies /biointeractive/heartbreak-mutations-and-maladies Lecture Genetic basis of disease, Circulation Wednesday, February 25, 1998 - 2:55pm

Although heart disease typically occurs after middle age, seemingly fit and healthy young individuals can die suddenly from unrecognized heart disease.

The Kidney's Tale: Of Salt and Hypertension /biointeractive/kidneys-tale-salt-and-hypertension Lecture Genetic basis of disease, Circulation Wednesday, February 25, 1998 - 2:58pm

Molecular genetic approaches have identified genes that, when mutated, cause either increased or decreased blood pressure.

The Double Life of RNA /biointeractive/double-life-rna Lecture Chemistry, Biochemistry, RNA, Gene expression Saturday, February 25, 1995 - 3:01pm

In four lectures, Nobel laureate Thomas R. Cech, PhD, discusses the ability of RNA to act as more than just an intermediary between DNA and proteins.

Catalysis: Chemical and Biochemical /biointeractive/catalysis-chemical-and-biochemical Lecture Chemistry, Biochemistry, RNA Saturday, February 25, 1995 - 3:04pm

Cellular enzymes are catalysts that tame reactions by accelerating them, lending specificity, and regulating their time and place.

RNA as an Enzyme: Discovery, Origins of Life, and Medical Possibilities /biointeractive/rna-enzyme-discovery-origins-life-and-medical-possibilities Lecture Chemistry, Biochemistry, RNA Saturday, February 25, 1995 - 3:07pm

Discovery of RNA's catalytic activity led to unexpected spin-offs, including a new scenario for the origin of life.

How to Accelerate a Reaction 100,000,000,000 Times Using Only RNA /biointeractive/how-accelerate-reaction-100000000000-times-using-only-rna Lecture Chemistry, Biochemistry, RNA Saturday, February 25, 1995 - 3:09pm

Studies of RNA catalytic centers have revealed much about their structure and mode of action.

Life at the End of the Chromosome: Another RNA Machine /biointeractive/life-end-chromosome-another-rna-machine Lecture Chemistry, Biochemistry, DNA, RNA Saturday, February 25, 1995 - 3:11pm

The chromosome ends, or telomeres, are necessary for DNA stability and replication.

The Making of the Fittest: Evolving Switches, Evolving Bodies /biointeractive/making-fittest-evolving-switches-evolving-bodies Short Film Mechanisms of evolution, Gene expression, Gene regulation Tuesday, October 16, 2012 - 5:01pm

After the end of the last ice age 10,000 years ago, populations of marine stickleback fish became stranded in freshwater lakes dotted throughout the Northern Hemisphere in places like Alaska and British Columbia. These fish have adapted to a freshwater environment drastically different than the ocean.

The Making of the Fittest: Natural Selection and Adaptation /biointeractive/making-fittest-natural-selection-and-adaptation Short Film Mechanisms of evolution, Natural selection, Evolution of populations, Gene regulation Wednesday, October 12, 2011 - 5:04pm

The rock pocket mouse is a living example of Darwin’s process of natural selection. Also available in Spanish.

The Making of the Fittest: The Birth and Death of Genes /biointeractive/making-fittest-birth-and-death-genes Short Film Mechanisms of evolution, DNA, Circulation, History of science Wednesday, October 12, 2011 - 5:05pm

Scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

The Making of the Fittest: Natural Selection in Humans /biointeractive/making-fittest-natural-selection-humans Short Film Human evolution, Mendelian inheritance, Genetic basis of disease, Infectious disease Wednesday, October 12, 2011 - 5:08pm

In some parts of the world, there is an intimate connection between the infectious parasitic disease malaria and the genetic disease sickle cell anemia. Also available in Spanish

The Day the Mesozoic Died /biointeractive/day-mesozoic-died Short Film Paleobiology, Chemistry, Earth history, History of science, Scientific methodology Thursday, October 11, 2012 - 11:45am

The disappearance of the dinosaurs at the end of the Cretaceous period posed one of the greatest, long-standing scientific mysteries. This three-act film tells the story of the extraordinary detective work that solved it. Also available in Spanish.

Stickleback Evolution Virtual Lab /biointeractive/stickleback-evolution-virtual-lab Virtual Lab Paleobiology, Mechanisms of evolution, Statistics and math, Scientific methodology Wednesday, February 27, 2013 - 11:10am

This virtual lab teaches skills of data collection and analysis to study evolutionary processes using stickleback fish and fossil specimens.

Transgenic Fly Virtual Lab /biointeractive/transgenic-fly-virtual-lab Virtual Lab DNA, Behavior, Biotechnology Sunday, February 27, 2000 - 11:24am

The lab will familiarize you with the science and techniques used to make transgenic flies to study circadian rhythms.

Bacterial Identification Virtual Lab /biointeractive/bacterial-identification-virtual-lab Virtual Lab Bacteria, Bioinformatics, DNA, Biotechnology Saturday, February 27, 1999 - 11:32am

This virtual lab will familiarize you with the science and techniques used to identify different types of bacteria based on their DNA sequences.

Cardiology Virtual Lab /biointeractive/cardiology-virtual-lab Virtual Lab Genetic basis of disease, Circulation, Biotechnology Friday, February 27, 1998 - 11:36am

NEW! HTML 5 support added! This virtual lab will familiarize you with heritable diseases of the heart. Learn about the diagnostic tools used to examine and diagnose patients.

Neurophysiology Virtual Lab /biointeractive/neurophysiology-virtual-lab Virtual Lab Animals, Neuroscience, Cell signaling Thursday, February 27, 1997 - 11:38am

In this virtual lab, you will record electrical activities of individual neurons, identify by response to stimuli, and use dyes to visualize their morphology.

Immunology Virtual Lab /biointeractive/immunology-virtual-lab Virtual Lab Immunology, Biotechnology Tuesday, February 27, 1996 - 11:42am

This virtual lab teaches the procedures of performing an ELISA test to determine whether a particular antibody is present in a patient's blood sample.

Creating Phylogenetic Trees from DNA Sequences /biointeractive/creating-phylogenetic-trees-dna-sequences Click & Learn Phylogeny and classification, Bioinformatics, DNA Sunday, February 5, 2012 - 2:39pm

This Click and Learn explains how DNA sequences can be used to generate such trees, and how to interpret them. English version is ADA accessible.

From Birds to People: The West Nile Virus Story /biointeractive/from-birds-to-people-the-west-nile-virus-story Click & Learn Virus, Infectious disease Monday, February 27, 2012 - 5:28pm

West Nile virus infects mosquitoes, birds, and people—with very different consequences.

Skeletons Reveal Human and Chimpanzee Evolution /biointeractive/skeletons-reveal-human-and-chimpanzee-evolution Click & Learn Paleobiology, Human evolution, Skin, muscles, and bones Monday, February 27, 2012 - 5:41pm

Comparing features of a 4.4-million-year-old fossil skeleton to those of human and chimpanzee skeletons sheds light on our evolutionary history.

Recent Adaptations in Humans /biointeractive/recent-adaptations-humans Click & Learn Human evolution, DNA, Gene regulation Monday, February 27, 2012 - 5:44pm

Lactose tolerance, sickle cell anemia, and bitter taste perception are three examples of recently evolved human traits.

Regulation of the Lactase Gene /biointeractive/regulation-of-the-lactase-gene Click & Learn Human evolution, DNA, Gene expression, Gene regulation Monday, February 27, 2012 - 5:48pm

Lactase persistence results from a mutation that changes how transcription factors interact, thereby affecting gene expression.

Are You a Morning or an Evening Person? /biointeractive/are-you-morning-or-evening-person Click & Learn Behavior Sunday, February 27, 2000 - 5:50pm

This survey, developed by Horne and Ostberg, will let you determine if you are a morning or an evening person.

Test Your Knowledge of Sex Determination /biointeractive/test-your-knowledge-sex-determination Click & Learn Mendelian inheritance, DNA, Reproduction Tuesday, February 27, 2001 - 5:52pm

Answer the questions in this online quiz to test your knowledge of what determines the sex of a human, a fruit fly, and a snapping turtle.

Using the Scientific Process to Study Human Evolution /biointeractive/using-scientific-process-study-human-evolution Click & Learn Paleobiology, Human evolution, Scientific methodology Tuesday, February 28, 2012 - 12:19pm

Paleoanthropology provides an excellent example of the scientific process at work. Also available in Spanish.

Stopping Mosquito-Borne Disease /biointeractive/stopping-mosquito-borne-disease Click & Learn Virus, Infectious disease Sunday, February 28, 2010 - 12:21pm

Learn about the nature of vector-borne diseases, and the life cycle of the dengue vector mosquito.

DNA Sequence Assembly /biointeractive/dna-sequence-assembly Click & Learn DNA, Bioinformatics, Biotechnology Sunday, February 28, 2010 - 12:23pm

Learn the principles of how DNA is sequenced and assembled into whole genomes using the Sanger method, shotgun sequencing, or ultra-deep sequencing.

Virochip DNA Microarray /biointeractive/virochip-dna-microarray Click & Learn Virus, Bioinformatics, Biotechnology Sunday, February 28, 2010 - 12:24pm

Answer interactive questions to explore the logic of the Virochip microarray design, particularly how evolutionary relationships can be used to detect new viruses.

Sorting Seashells /biointeractive/sorting-seashells Click & Learn Phylogeny and classification, Biodiversity, Bioinformatics Saturday, February 28, 2009 - 12:28pm

Explore principles of taxonomy by sorting seashells according to their morphological characteristics and constructing an evolutionary tree.

Symbiotic Bioluminescence /biointeractive/symbiotic-bioluminescence Click & Learn Biodiversity, Behavior, Cell signaling Saturday, February 28, 2009 - 12:30pm

Explore the biology of the symbiotic relationship between the Hawaiian Bobtail squid and bioluminescent bacteria Vibrio fischeri.

Bacterial Quorum Sensing /biointeractive/bacterial-quorum-sensing Click & Learn Biodiversity, Gene regulation, Cell signaling Saturday, February 28, 2009 - 12:33pm

Understand how quorum sensing works by reasoning through experiments involving genetically-engineered bioluminescent bacteria.

Sex Verification Testing of Athletes /biointeractive/testing-athletes Click & Learn DNA, Reproduction, Developmental biology Friday, July 6, 2018 - 10:56am

This interactive explores the biology of sex determination and development in humans, set against the backdrop of the different sex testing policies implemented throughout sports history.

Microarray Manufacturing Technology /biointeractive/microarray-manufacturing-technology Click & Learn Chemistry, Genomics, DNA, Biotechnology Thursday, February 28, 2002 - 12:36pm

How both gene chips and microarray slides are created.

Small-Molecule Diversity /biointeractive/small-molecule-diversity Click & Learn Chemistry Thursday, February 28, 2002 - 12:44pm

Small molecules are chemicals that can interact with proteins to affect their functions. Learn about the structure and biological functions of various small molecules like sugar and caffeine.

Neural Control of Walking and Running /biointeractive/neural-control-walking-and-running Click & Learn Skin, muscles, and bones, Neuroscience, Behavior Thursday, February 28, 2008 - 1:25pm

Different gaits employed by animals and how the nervous system is able to switch between them. Also available in Spanish.

Electrical Activity of Neurons /biointeractive/electrical-activity-neurons Click & Learn Neuroscience, Cell structure, Cell signaling Thursday, February 28, 2008 - 1:32pm

Measuring neuronal activity, generating action potentials, and recording the firing of individual neurons.

Cells of the Immune System /biointeractive/cells-of-the-immune-system Click & Learn Immunology Wednesday, February 28, 2007 - 1:35pm

An overview of the immune system, concentrating on the roles played by B and T lymphocytes, and the antigen-presentation system.

Retroviruses and Viral Diversity /biointeractive/retroviruses-and-viral-diversity Click & Learn Virus, Infectious disease Wednesday, February 28, 2007 - 1:37pm

A brief discussion of what makes a virus a retrovirus, and how they differ from other types of viruses.

Drug Adherence and Resistance /biointeractive/drug-adherence-and-resistance Click & Learn Virus, Infectious disease Wednesday, February 28, 2007 - 1:39pm

Problems associated with adherence to antiviral drugs, and a student activity that mimics adherence to a multi-drug regimen.

Tissue Regeneration in Animals /biointeractive/tissue-regeneration-animals Click & Learn Skin, muscles, and bones, Stem cells Tuesday, February 28, 2006 - 1:40pm

An overview and comparison of different regenerative capabilities in many different organisms.

Stem-Cell-Based Therapies /biointeractive/stem-cell-based-therapies Click & Learn Stem cells Tuesday, February 28, 2006 - 1:41pm

An exploration of current and future therapies.

Visualizing Gene-Expression Patterns /biointeractive/visualizing-gene-expression-patterns Click & Learn Biochemistry, Gene expression, Biotechnology Monday, February 28, 2005 - 1:44pm

Learn about the different ways scientists are able to detect when genes are being expressed in various tissues.

Natural and Artificial Selection /biointeractive/natural-and-artificial-selection Click & Learn Natural selection, Artificial selection Monday, February 28, 2005 - 1:46pm

Learn about artificial and natural selection.

Genetic Switches /biointeractive/genetic-switches Click & Learn Mechanisms of evolution, Gene regulation Monday, February 28, 2005 - 1:47pm

Learn about how gene switches can control expression of genes in different tissues.

RNA Interference /biointeractive/rna-interference Click & Learn RNA, Gene regulation, Biotechnology Tuesday, February 28, 1995 - 1:49pm

RNA interference is an exciting new research tool for shutting down genes. It could also yield new medical treatments.

RNA Diversity /biointeractive/rna-diversity Click & Learn RNA Tuesday, February 28, 1995 - 1:50pm

RNA is an information molecule that can also function as an enzyme. Learn about the many different forms that RNA can take.

Structure and Function of Telomeres /biointeractive/structure-and-function-telomeres Click & Learn DNA, RNA Tuesday, February 28, 1995 - 1:51pm

This mini-lesson covers the research on telomeres that has happened since the 1995 Holiday Lectures.

Measuring Obesity /biointeractive/measuring-obesity Click & Learn Nutrition, Statistics and math, Scientific methodology Saturday, February 28, 2004 - 1:53pm

There is no way to directly measure how much fat a living person has. Learn about the various methods used by researchers and fitness advisors to estimate a person’s body fat.

Molecular Structure of Fat /biointeractive/molecular-structure-fat Click & Learn Chemistry, Lipids, Nutrition, Cell structure Saturday, February 28, 2004 - 1:54pm

This slide show delves into the various molecular shapes that fat can take.

How The Body Uses Fat /biointeractive/how-body-uses-fat Click & Learn Carbohydrates, Lipids, Nutrition, Respiration Saturday, February 28, 2004 - 1:56pm

This slide show explores some of the ways the body processes fat, including digestion, transport, conversion, and energy extraction.

The p53 Gene and Cancer /biointeractive/p53-gene-and-cancer Click & Learn DNA, Cancer Friday, February 28, 2003 - 1:57pm

This Click and Learn explains the structure and function of the p53 protein as well as how the protein’s activity is regulated.

The Proteasome and Protein Regulation /biointeractive/proteasome-and-protein-regulation Click & Learn Proteins, Neuroscience, Cell structure Friday, February 28, 2003 - 1:59pm

Learn about the structure and function of this fascinating cellular machine.

How to Analyze DNA Microarray Data /biointeractive/how-analyze-dna-microarray-data Click & Learn Genomics, Bioinformatics, Biotechnology, Statistics and math Thursday, February 28, 2002 - 2:01pm

DNA microarrays, or gene chips, are an important new technology for genomic research. Learn how researchers use computing to analyze and interpret the huge datasets generated by microarray experiments.

Using DNA to Trace Human Migration /biointeractive/using-dna-trace-human-migration Click & Learn Human evolution, Genomics Thursday, February 28, 2002 - 2:02pm

All living humans originated from populations of ancestors who migrated out of Africa less than 100,000 years ago. Learn how scientists have used genetic markers to trace the migration routes and origins of modern human populations.

Test Your Knowledge of Microbes /biointeractive/test-your-knowledge-microbes Click & Learn Virus, Bacteria, Infectious disease Sunday, February 28, 1999 - 2:04pm

Take this quiz to see how well you understand some of the topics covered in the 1999 Holiday Lectures on infectious disease.

Understanding Cancer Diversity /biointeractive/understanding-cancer-diversity Article Cancer Friday, February 28, 2003 - 4:27pm

Cancer occurs when a single cell acquires the ability to reproduce aggressively and to invade other tissues. Left unchecked, this anarchy destroys the cellular society. It interferes with the body's normal function, destroys organs, and eventually kills the organism.

The Evolution of Cancer /biointeractive/evolution-cancer Article Cancer Friday, February 28, 2003 - 4:31pm

Cancers grow and spread by a process akin to evolution.

How Did We Get Here? /biointeractive/how-did-we-get-here Article Mechanisms of evolution Friday, March 4, 2005 - 3:41pm

From the inheritance of acquired traits to natural selection to evo devo, evolutionary theory has itself evolved.

Winogradsky columns: Microbial ecology in the classroom /biointeractive/winogradsky-columns-microbial-ecology-classroom Activity Ecosystems, Chemistry, Bacteria, Earth history Monday, March 5, 2012 - 12:09pm

An activity that recreates zones of microbial activity in a glass column. To accompany the lecture series Changing Planet: Past, Present, Future.

Film Guides: The Day the Mesozoic Died /biointeractive/film-guides-day-mesozoic-died Film Guide Mechanisms of evolution, Paleobiology, Earth history, History of science, Scientific methodology Monday, March 5, 2012 - 2:52pm

The following classroom-ready resources complement The Day the Mesozoic Died, which tells the story of the extraordinary detective work that led to the stunning discovery that an asteroid struck Earth 66 million years ago, triggering a mass extinction of animals, plants and even microorganisms.

Article: The Day the Mesozoic Died /biointeractive/article-day-mesozoic-died Article Paleobiology, Earth history, History of science, Scientific methodology Monday, March 5, 2012 - 3:17pm

A short article by Dr. Sean B. Carroll detailing the discoveries covered in the film The Day The Mesozoic Died.

Chemical Signatures of Asteroid Impacts /biointeractive/chemical-signatures-asteroid-impacts Activity Chemistry, Earth history Monday, March 5, 2012 - 3:26pm

A lesson in which students analyze the chemical data that led researchers to conclude that the K-T boundary layer contained an extraordinary concentration of iridium. 

Distribution of Elements in Earth’s Crust /biointeractive/distribution-elements-earth-s-crust Activity Chemistry, Geology Monday, March 5, 2012 - 3:33pm

A lesson in which students read a passage and answer questions about the information presented, testing their non-fiction reading comprehension.

Calculating Iridium Fallout From an Asteroid Impact /biointeractive/calculating-iridium-fallout-asteroid-impact Activity Chemistry, Earth history, Statistics and math Monday, March 5, 2012 - 3:36pm

A worksheet in which students calculate how much iridium was released, and eventually deposited all over the Earth, by the impact of the asteroid that caused the K-T extinction.

Weighing the Evidence for a Mass Extinction—In the Ocean /biointeractive/weighing-evidence-mass-extinction-ocean Activity Paleobiology, Mechanisms of evolution, Protists, Earth history Monday, March 5, 2012 - 3:49pm

A hands-on activity in which students see first-hand the difference in foraminifera fossils below and above the K-T boundary. Also available in Spanish.

Film Guides: Evolving Switches, Evolving Bodies /biointeractive/film-guides-evolving-switches-evolving-bodies Film Guide Mechanisms of evolution, Gene expression, Gene regulation Friday, March 8, 2013 - 9:56am

These classroom-ready resources complement the short film Evolving Switches, Evolving Bodies, which tells the story of the dramatic transformation of stickleback fish as they adapted to living in freshwater habitats drastically different from the ocean.

Worksheet for The Stickleback Evolution Virtual Lab /biointeractive/worksheet-stickleback-evolution-virtual-lab Activity Mechanisms of evolution, Paleobiology, Scientific methodology, Statistics and math Monday, March 7, 2011 - 10:09am

A worksheet that guides students through The Stickleback Evolution Virtual Lab. The virtual lab lets students learn firsthand the methods for analyzing body structure in stickleback collected from lakes and fossils recovered from a quarry. Students measure, record, and graph their results to discover evolutionary patterns.

Film Guides: Natural Selection and Adaptation /biointeractive/film-guides-natural-selection-and-adaptation Film Guide Human evolution, Phylogeny and classification Monday, March 7, 2011 - 10:32am

The following classroom-ready resources complement The Making of the Fittest: Natural Selection and Adaptation, which describes the physical and genetic evolutionary changes in rock pocket mouse populations. Also available in Spanish.

Color Variation Over Time in Rock Pocket Mouse Populations /biointeractive/color-variation-over-time-rock-pocket-mouse-populations Activity Mechanisms of evolution, Natural selection, Evolution of populations Monday, March 7, 2011 - 10:44am

A data collection and analysis lesson that examines selection for coat color in pocket mouse populations on different color substrates over time. Also available in Spanish.

Allele and Phenotype Frequencies in Rock Pocket Mouse Populations /biointeractive/allele-and-phenotype-frequencies-rock-pocket-mouse-populations Activity Natural selection, Evolution of populations, Statistics and math Monday, March 7, 2011 - 11:06am

A lesson that uses real rock pocket mouse data collected by Dr. Michael Nachman and his colleagues to illustrate the Hardy-Weinberg principle.

Molecular Genetics of Color Mutations in Rock Pocket Mice /biointeractive/molecular-genetics-color-mutations-rock-pocket-mice Activity Mechanisms of evolution, Evolution of populations, DNA, Gene expression, Skin, muscles, and bones Monday, March 7, 2011 - 11:14am

A lesson that requires students to transcribe and translate portions of the wild-type and mutant rock pocket mouse Mc1r genes and compare sequences to identify the locations and types of mutations responsible for the coat color variation described in the film. Also available in Spanish.

Biochemistry and Cell Signaling Pathway of the Mc1r Gene /biointeractive/biochemistry-and-cell-signaling-pathway-mc1r-gene Activity Mechanisms of evolution, Biochemistry, Proteins, Cell signaling Monday, March 7, 2011 - 11:21am

An advanced lesson that requires students to analyze partial DNA sequences of the Mc1r gene and identify the effects of mutations on the MC1R protein pathway.

Natural Selection and Evolution of Rock Pocket Mouse Populations /biointeractive/natural-selection-and-evolution-rock-pocket-mouse-populations Activity Mechanisms of evolution, Evolution of populations, Proteins Monday, March 7, 2011 - 11:27am

An activity in which students analyze amino acid data and draw conclusions about the evolution of coat color phenotypes in different rock pocket mouse populations.

Following the Trail of Evidence /biointeractive/following-trail-evidence Activity Earth history, Scientific methodology Wednesday, March 7, 2012 - 2:22pm

A worksheet in which students write down the evidence that led to the discovery that an asteroid struck Earth about 66 million years ago, causing a mass extinction. Also available in Spanish.

Film Guides: The Birth and Death of Genes /biointeractive/film-guides-birth-and-death-genes Film Guide Mechanisms of evolution, Natural selection, DNA, Circulation, History of science Monday, March 7, 2011 - 2:35pm

The following classroom-ready resources complement The Making of the Fittest: The Birth and Death of Genes, which describes how scientists have pieced together the evolutionary history of the Antarctic icefish. The icefish makes an excellent case study for genetic evolution as both the gain and loss of genes have led to key adaptations.

Icefish Adaptations /biointeractive/icefish-adaptations Activity Mechanisms of evolution, Circulation Monday, March 7, 2011 - 2:42pm

A simple activity that investigates the importance of antifreeze proteins to icefish survival.

The Molecular Evolution of Gene Birth and Death /biointeractive/molecular-evolution-gene-birth-and-death Activity Mechanisms of evolution, DNA, Gene expression, Genetic basis of disease Monday, March 7, 2011 - 2:46pm

An advanced lesson that describes the role of mutations in the birth and death of genes. It includes background information, examples, video clips, and animations.

Demonstration: Viscosity of Icefish and Non-Icefish Blood /biointeractive/demonstration-viscosity-icefish-and-non-icefish-blood Activity Mechanisms of evolution, Circulation Monday, March 7, 2011 - 2:54pm

A simple demonstration that uses readily-available materials to simulate how blood pumps through the circulatory system of icefish and other fish.

Ice Crystal Formation in Icefish and Non-Icefish Blood /biointeractive/ice-crystal-formation-icefish-and-non-icefish-blood Activity Chemistry, Circulation Monday, March 7, 2011 - 2:59pm

A dramatic demonstration that simulates how tiny ice crystals would form and grow in the blood of most fish if they ventured into the icy waters of the Antarctic.

Film Guides: Natural Selection in Humans /biointeractive/film-guides-natural-selection-humans Film Guide Human evolution, Genetic basis of disease, History of science Monday, March 7, 2011 - 3:04pm

The following classroom-ready resources complement The Making of the Fittest: Natural Selection in Humans, which describes the connection between malaria and sickle cell anemia—one of the best-understood examples of natural selection in humans. Also available in Spanish.

A Lesson on the Nature of Science /biointeractive/lesson-nature-science Activity History of science, Science and society, Scientific methodology Thursday, March 7, 2013 - 3:11pm

A worksheet designed to show students how scientists make their discoveries. It provides students with background information about how Dr. Allison's work built upon the contributions made by other scientists. 

Testing a Hypothesis /biointeractive/testing-hypothesis Activity Evolution of populations, Genetic basis of disease, History of science, Scientific methodology Wednesday, March 7, 2012 - 3:15pm

A worksheet designed to actively engage students as they watch the film. Students are asked to answer questions pertaining to the information provided in the film.

How Do Fibers Form? /biointeractive/how-do-fibers-form Activity Proteins, Genetic basis of disease Monday, March 7, 2011 - 3:20pm

A hands-on activity in which students construct models of sickle-cell hemoglobin fibers inside red blood cells to illustrate how changes in the structure of a protein can affect cell shape. Students are then asked to relate these changes to disease symptoms. Also available in Spanish.

Population Genetics, Selection, and Evolution /biointeractive/population-genetics-selection-and-evolution Activity Natural selection, Population genetics, Statistics and math Monday, March 7, 2011 - 3:24pm

A hands-on activity that uses simulations with beads to teach students about population genetics, the Hardy-Weinberg principle, and how natural selection alters the frequency distribution of heritable traits. Also available in Spanish.

Mendelian Genetics, Probability, Pedigree, and Chi-Square Statistics /biointeractive/mendelian-genetics-probability-pedigree-and-chi-square-statistics Activity Population genetics, Mendelian inheritance, Statistics and math Thursday, March 7, 2013 - 3:28pm

A lesson that requires students to work through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria. These questions will probe students' understanding of Mendelian genetics, probability, pedigree analysis, and chi-square statistics. Also available in Spanish.

Classroom Activities: What is My Carbon Footprint? /biointeractive/classroom-activities-carbon-footprint Activity Climate, Human impacts, Science and society Thursday, March 7, 2013 - 3:33pm

To accompany the lecture series Changing Planet: Past, Present, Future. Using an online calculator, you will estimate your household’s carbon footprint and explore various actions to reduce it. Also available in Spanish.

Classroom Activities: Stem Cells and Diabetes /biointeractive/classroom-activities-stem-cells-and-diabetes Activity Developmental biology, Stem cells Tuesday, March 7, 2006 - 3:39pm

To accompany the lecture series Potent Biology: Stem Cells, Cloning, and Regeneration.

The Mosquito Life Cycle Activity /biointeractive/mosquito-life-cycle-activity Activity Behavior, Infectious disease, Scientific methodology Sunday, March 7, 2010 - 3:55pm

Students breed and observe mosquitoes in order to study their life cycle and demonstrate the utility of this data for public policy. Resources are also available in Spanish.

Biodiversity and Evolutionary Trees /biointeractive/biodiversity-and-evolutionary-trees Activity Phylogeny and classification, Biodiversity, Bioinformatics Saturday, March 7, 2009 - 5:39pm

Construct evolutionary trees by sorting seashells. To accompany the lecture series Exploring Biodiversity: The Search for New Medicines and the Sorting Seashells Click and Learn interactive.

Classroom Activities: Battling Beetles /biointeractive/classroom-activities-battling-beetles Activity Mechanisms of evolution, Natural selection, Evolution of populations Monday, March 7, 2005 - 6:01pm

To accompany the lecture series Evolution: Constant Change and Common Threads.

Classroom Activities: Variations in the Clam Species Clamys sweetus /biointeractive/classroom-activities-variations-clam-species-clamys-sweetus Activity Evolution of populations, Scientific methodology, Statistics and math Monday, March 7, 2005 - 6:05pm

To accompany the lecture series Evolution: Constant Change and Common Threads.

Classroom Activities: Gene Switches /biointeractive/classroom-activities-gene-switches Activity Mechanisms of evolution, Gene regulation, Developmental biology Monday, March 7, 2005 - 6:14pm

To accompany the lecture series Evolution: Constant Change and Common Threads.

Classroom Activities: Mirror-Tracing Activity /biointeractive/classroom-activities-mirror-tracing-activity Activity Neuroscience, Behavior Friday, March 7, 2008 - 6:18pm

To accompany the lecture series Making Your Mind: Molecules, Motion, and Memory.

Classroom Activities: Drug Adherence Activity /biointeractive/classroom-activities-drug-adherence-activity Activity Behavior, Infectious disease, Science and society Wednesday, March 7, 2007 - 6:24pm

To accompany the lecture series AIDS: Evolution of an Epidemic. In this activity, you simulate taking HIV antiretroviral drugs by using tic tac mints and Kool-Aid packets.

Classroom Activities: Planaria Regeneration Activity /biointeractive/classroom-activities-planaria-regeneration-activity Activity Neuroscience, Behavior, Cell growth and division, Stem cells Tuesday, March 7, 2006 - 6:30pm

This activity uses the planaria's property for regeneration and compares how long it takes for planaria cut in different places to regenerate a head. 

Classroom Activities: Pedigree Analysis Activity /biointeractive/classroom-activities-pedigree-analysis-activity Activity Mendelian inheritance, Genetic basis of disease Friday, March 7, 2003 - 6:34pm

To accompany the lecture series Learning from Patients: The Science of Medicine.

Classroom Activities: Molecular Menagerie /biointeractive/classroom-activities-molecular-menagerie Activity Chemistry, Scientific methodology Thursday, March 7, 2002 - 6:38pm

To accompany the lecture series Scanning Life's Matrix: Genes, Proteins, and Small Molecules.

Teacher Guide: AP Biology /biointeractive/teacher-guide-ap-biology Teacher Guide Mechanisms of evolution, Gene regulation, Immunology, Biotechnology Thursday, March 7, 2013 - 6:44pm

This guide correlates all the resources available on the Holiday Lectures on Science DVDs and throughout the BioInteractive.org website to specific Big Ideas, Enduring Understandings, and Essential Knowledge threads of the new AP® Biology Curriculum Framework. 

Film Guides: Got Lactase? The Co-evolution of Genes and Culture /biointeractive/film-guides-got-lactase-co-evolution-genes-and-culture Film Guide Human evolution, Gene regulation Tuesday, March 8, 2011 - 10:30am

The following classroom-ready resources complement Got Lactase? The Co-evolution of Genes and Culture, which tells the story of the evolution of the ability to digest lactose, a genetic trait that arose in humans within the last 10,000 years in some pastoralist cultures.

The Making of the Fittest: Got Lactase? The Co-evolution of Genes and Culture /biointeractive/making-fittest-got-lactase-co-evolution-genes-and-culture Short Film Human evolution, Gene expression, Gene regulation, Nutrition Friday, March 8, 2013 - 10:38am

Follow human geneticist Spencer Wells, Director of the Genographic Project of the National Geographic Society, as he tracks down the genetic changes associated with the ability to digest lactose as adults. Also available in Spanish.

Teacher Guide: Biotechnology /biointeractive/teacher-guide-biotechnology Teacher Guide DNA, Biotechnology Friday, March 8, 2013 - 11:19am

Topics include: PCR, DNA Sequencing, Genetic Engineering, and Microarray. This guide includes multiple classroom-ready worksheets to accompany HHMI’s virtual labs.

Teacher Guide: DNA /biointeractive/teacher-guide-dna Teacher Guide Nucleic acids, DNA Friday, March 8, 2013 - 11:28am

Topics include: DNA structure and function, DNA replication, damage to DNA and eukaryotic chromosomal structure.

Teacher Guide: Evolution /biointeractive/teacher-guide-evolution Teacher Guide Natural selection, Artificial selection, Evolution of populations, Human evolution, Phylogeny and classification, Population genetics Friday, March 8, 2013 - 11:31am

Topics include: natural selection, artificial selection, population genetics, human adaptations and evolution, and phylogenetics.

Teacher Guide: Gene Expression /biointeractive/teacher-guide-gene-expression Teacher Guide DNA, RNA, Gene expression Friday, March 8, 2013 - 11:35am

Topics include: Gene expression, RNA structure and function, transcription, RNA processing, translation, and post-translational events.

Teacher Guide: Gene Regulation /biointeractive/teacher-guide-gene-regulation Teacher Guide DNA, RNA, Gene regulation, Genetic basis of disease Friday, March 8, 2013 - 11:40am

Topics include: Gene regulation mechanisms and examples, gene regulation and human disease, and RNA interference.

Teacher Guide: Immunology /biointeractive/teacher-guide-immunology Teacher Guide Virus, Immunology, Infectious disease Friday, March 8, 2013 - 11:47am

Topics include: Immunology, HIV immune response and drug development, ELISA, CCR5 co-receptor mutation, vaccine development, dengue fever, and immunological response

How Novel Icefish Genes Can Improve Human Health /biointeractive/how-novel-icefish-genes-can-improve-human-health Activity Mechanisms of evolution, Skin, muscles, and bones, Circulation Tuesday, March 8, 2011 - 12:10pm

A lesson that requires students to read detailed scientific passages and explain how an understanding of specific icefish adaptations might lead to a treatment or cure for human disorders, such as osteoporosis and anemia. 

Classroom Activities: EarthViewer /biointeractive/classroom-activities-earthviewer Activity Paleobiology, Earth history, Climate Thursday, March 8, 2012 - 12:28pm

EarthViewer was designed as an interactive learning tool. Download the PDF linked in the right hand column for some ideas on how to use the app in your class, or click on the EarthViewer link to find out more about the app.

Foraminifera—Earth's Microscopic Recordkeepers /biointeractive/foraminifera-earths-microscopic-recordkeepers Poster Mechanisms of evolution, Biodiversity, Protists, Earth history Thursday, March 8, 2012 - 4:41pm

A poster from the 2012 Holiday Lectures on Science, Changing Planet: Past, Present, Future. It details the importance of foraminifera, known as "forams" for short, in discovering significant changes in Earth's past. 

Poster: Winogradsky Column—Microbial Evolution in a Bottle /biointeractive/poster-winogradsky-column-microbial-evolution-bottle Poster Communities, Biodiversity, Bacteria, Earth history Thursday, March 8, 2012 - 4:55pm

A poster from the 2012 Holiday Lectures on Science, Changing Planet: Past, Present, Future. It shows the different organisms and metabolic diversity that results in a miniature model called a Winogradsky column.

Earth Evolution—The Intersection of Geology and Biology /biointeractive/earth-evolution-intersection-geology-and-biology Poster Paleobiology, Phylogeny and classification, Geology, Earth history Thursday, March 8, 2012 - 4:58pm

A poster from the 2012 Holiday Lectures on Science, Changing Planet: Past, Present, Future. It illustrates how the Earth has evolved over the past 4.6 billion years, and highlights how that evolution influences biological evolution.

Human Evolution Within the Tree of Life /biointeractive/human-evolution-within-tree-life Poster Paleobiology, Human evolution, Phylogeny and classification, Biodiversity Tuesday, March 8, 2011 - 5:00pm

The poster from the 2011 Holiday Lectures on Science, Bones, Stones and Genes: The Origin of Modern Humans. It provides a unique look at the classic "tree of life" and features a timeline of various hominid fossils and their stone tool usage.

Viral Diversity /biointeractive/viral-diversity Poster Biodiversity, Virus, Infectious disease Monday, March 8, 2010 - 5:02pm

The poster from the 2010 Holiday Lectures, Viral Outbreak: The Science of Emerging Disease, illustrating the size, geometry, and different classifications of viruses.

How Neurons Work /biointeractive/how-neurons-work Poster Neuroscience, Cell structure, Cell signaling Saturday, March 8, 2008 - 5:05pm

The poster from the 2008 Holiday Lectures on Science, Making Your Mind: Molecules, Motion, and Memory. It illustrates the structure and function of a neuron, including how it transmits electrical and chemical signals.

(This poster is designed to printed at a maximum size of 29.5" x 23.5".)

HIV Life Cycle and Drug Targets /biointeractive/hiv-life-cycle-and-drug-targets Poster Virus, Immunology, Infectious disease Thursday, March 8, 2007 - 5:07pm

The poster from the 2007 Holiday Lectures on Science, AIDS: Evolution of an Epidemic. It shows each stage of the HIV life cycle and highlights points in the cycle that have been targeted by anti-retroviral drugs.

Fossil Evidence and Evolution /biointeractive/fossil-evidence-and-evolution Poster Paleobiology, Earth history Tuesday, March 8, 2005 - 5:10pm

The poster from the 2005 Holiday Lectures on Science, Evolution: Constant Change and Common Threads. Place the fossils in the right geological era, period, and epoch.

(This poster is designed to printed at a maximum size of 29.5" x 23.5".)

Determining the Size and Energy of the K-T Asteroid /biointeractive/determining-size-and-energy-k-t-asteroid Activity Paleobiology, Earth history, Statistics and math Thursday, March 15, 2012 - 2:12pm

A lesson in which students calculate the mass, size, and kinetic energy of the K-T asteroid based on the total abundance of iridium in the K-T boundary layer.

BioInteractive—Technical Tips and Troubleshooting /biointeractive/help Friday, March 22, 2013 - 9:07am

Help with Virtual Labs, Click and Learns, Interactive Videos, and Downloadable Videos.

Xs and Os: The Tic-Tac-Toe of Sex Determination /biointeractive/xs-and-os-tic-tac-toe-sex-determination Activity Mendelian inheritance, Reproduction Thursday, March 22, 2001 - 1:53pm

A jigsaw format activity to explore the sex determination mechanisms of seven organisms.

Weighing the Evidence for a Mass Extinction—On Land /biointeractive/weighing-evidence-mass-extinction-land Activity Mechanisms of evolution, Paleobiology, Plants, Earth history Sunday, April 1, 2012 - 10:58am

A lesson in which students analyze graphs and data on pollen grains and fern spores to form a picture of the living landscape before and after the K-T mass extinction.

Changing Planet: Past, Present, Future /biointeractive/changing-planet-past-present-future Lecture Paleobiology, Earth processes, Earth history, Climate, History of science, Science and society Monday, April 9, 2012 - 10:38am

Has Earth changed over deep time? How did Earth shape life and life shape Earth? What does Earth's climate in the distant past tell us about the future?

The Deep History of a Living Planet /biointeractive/deep-history-living-planet Lecture Paleobiology, Bacteria, Earth history, Scientific methodology Monday, April 9, 2012 - 10:52am

Microbes have been the dominant life form throughout Earth's history. Eukaryotes and animals evolved only after microbes evolved oxygen-generating photosynthesis.

Building Scientific Knowledge: The Story of Plate Tectonics /biointeractive/building-scientific-knowledge-story-plate-tectonics Lecture Earth history, History of science, Science and society, Scientific methodology Monday, April 9, 2012 - 10:58am

The theory of plate tectonics took many decades to become accepted. The process by which it was finally accepted provides a fascinating glimpse into how scientists build new scientific consensus.

Earth's Climate: Back to the Future /biointeractive/earths-climate-back-future Lecture Chemistry, Earth processes, Climate, Science and society Monday, April 9, 2012 - 11:07am

Earth has been both cooler and warmer in the past, but the change is usually gradual. The current rate of carbon dioxide increase is unprecedented in human history, and solutions to mitigate its effect on global warming are challenging to implement.

Climate Change: How Do We Know We're Not Wrong? /biointeractive/climate-change-how-do-we-know-were-not-wrong Lecture Climate, Human impacts, History of science, Science and society Monday, April 9, 2012 - 11:14am

Scientific evidence for global climate change is overwhelming, yet the American public remains skeptical. History provides insights into how a Cold War-era think tank became an influential source of anti-regulation sentiment.

Climate Discussion with Students /biointeractive/climate-discussion-students Lecture Climate, Human impacts, Science and society Monday, April 9, 2012 - 11:18am

A discussion on climate change with the students attending the 2012 Holiday Lectures on Science.

Discussion with Students on The Day The Mesozoic Died Short Film /biointeractive/discussion-students-day-mesozoic-died-short-film Lecture Paleobiology, Earth history, History of science, Scientific methodology Monday, April 9, 2012 - 11:25am

Students discuss the short film after a screening at the 2012 Holiday Lectures on Science.

The Principle of Isostasy /biointeractive/principle-isostasy Clip Geology, Earth processes, History of science Wednesday, April 18, 2012 - 8:56am

Continents rose in elevation after ice sheets from the last ice age retreated. This suggested that the underlying mantle is pliable.

Isostasy is Key to Understanding Continental Drift /biointeractive/isostasy-key-understanding-continental-drift Clip Earth history, History of science Wednesday, April 18, 2012 - 9:04am

The concept that continents float on a pliable mantle is an important element of the theory of continental drift.

Protect Our Winters /biointeractive/protect-our-winters Clip Climate, Science and society Wednesday, April 18, 2012 - 9:07am

A grassroots effort by winter sports professionals aims to convince the government to take action on climate change.

Interview with Andrew Knoll, PhD /biointeractive/interview-andrew-knoll-phd Interview Careers in science Wednesday, April 18, 2012 - 9:14am

Dr. Knoll describes the path to becoming a geologist, and explains the importance of collaboration in scientific research.

Interview with Naomi Oreskes, PhD /biointeractive/interview-naomi-oreskes-phd Interview History of science, Careers in science, Science and society Wednesday, April 18, 2012 - 9:17am

Dr. Oreskes explains her switch from research science to science history, and what led her to write Merchants of Doubt.

Interview with Daniel Schrag, PhD /biointeractive/interview-daniel-schrag-phd Interview Careers in science, Science and society Wednesday, April 18, 2012 - 10:54am

Dr. Schrag recalls his parallel interests in earth science and political science and how the two have merged over the years.

Interview with JC Creveling /biointeractive/interview-jc-creveling Interview Careers in science Wednesday, April 18, 2012 - 10:58am

A graduate student in the Knoll lab, Ms. Creveling explains how she selects field sites, and what sparked her interest in geology.

Interview with Tom Laakso /biointeractive/interview-tom-laakso Interview Statistics and math, Careers in science Wednesday, April 18, 2012 - 11:01am

A graduate student in the Schrag lab, Mr. Laakso uses computer modeling of Earth's atmosphere to help predict changes to come.

Interview with Julie Shoemaker, PhD /biointeractive/interview-julie-shoemaker-phd Interview Climate, Careers in science Wednesday, April 18, 2012 - 11:08am

A postdoc in the Schrag lab, Dr. Shoemaker works on the greenhouse gas methane, which has surprising natural and man-made sources.

How To Find a Dinosaur /biointeractive/how-find-dinosaur Scientists at Work Paleobiology, Earth history, Careers in science Wednesday, April 18, 2012 - 11:15am

Dr. Lyson describes dinosaur digs as well as his focus on prehistoric turtle fossils.

Arctic Island Was a Tropical Island 500 Million Years Ago /biointeractive/arctic-island-was-tropical-island-500-million-years-ago Animation Earth processes, Earth history Wednesday, April 18, 2012 - 11:18am

Reconstructing past continental plate movements reveals the island of Spitsbergen was tropical 500 million years ago.

Continental Movement Over the Past 200 Million Years /biointeractive/continental-movement-over-past-200-million-years Animation Earth processes, Earth history Wednesday, April 18, 2012 - 11:26am

The breakup of a supercontinent into several smaller continents explains the distribution of fossil and geologic evidence.

Daly's Model of Subduction /biointeractive/dalys-model-subduction Animation Earth processes, Earth history, History of science Wednesday, April 18, 2012 - 11:33am

An early model of continental drift proposed that parts of continental plates can sink into the mantle, allowing for movement.

Holmes' Model of Convection /biointeractive/holmes-model-convection Animation Earth processes, History of science Wednesday, April 18, 2012 - 11:53am

An early continental drift model proposed that mantle convection can produce continental movement and new plate formation.

Greenhouse Effect /biointeractive/greenhouse-effect Animation Climate, Human impacts Wednesday, April 18, 2012 - 11:58am

Sunlight that warms Earth is re-emitted as infrared radiation, which is absorbed by greenhouse gases and causes further warming.

The Geologic Carbon Cycle /biointeractive/geologic-carbon-cycle Animation Earth processes, Climate Wednesday, April 18, 2012 - 12:02pm

CO2 emitted by volcanoes into the atmosphere is removed by a series of chemical reactions related to rock weathering.

Dramatic Retreat of Arctic Sea Ice in 2012 /biointeractive/dramatic-retreat-arctic-sea-ice-2012 Animation Climate, Human impacts Wednesday, April 18, 2012 - 12:05pm

Arctic sea ice melted on an unprecedented scale in 2012, opening up the fabled Northwest and Northeast passages.

The Immune System: Friend and Foe /biointeractive/immune-system-friend-and-foe Lecture Immunology, Infectious disease Monday, April 22, 1996 - 8:19am

A wide overview of the immune system, presented by HHMI investigators John W. Kappler, PhD, and Philippa Marrack, PhD

How Immune Cells Create Trillions of Receptors from a Few Hundred Parts /biointeractive/how-immune-cells-create-trillions-receptors-few-hundred-parts Lecture Gene expression, Immunology, Cell signaling Monday, April 22, 1996 - 8:22am

The human body has at least a trillion ways of recognizing that something foreign has invaded.

How the Immune System Detects Invaders /biointeractive/how-immune-system-detects-invaders Lecture Immunology, Cell signaling Monday, April 22, 1996 - 8:30am

The immune system recognizes invaders in a complex way.

How the Host Avoids "Friendly Fire" /biointeractive/how-host-avoids-friendly-fire Lecture Immunology, Developmental biology, Cell signaling Monday, April 22, 1996 - 8:35am

Normally the trillions of lymphocytes in the human body do not attack their host. 

Stalking the Elusive Pathogen /biointeractive/stalking-elusive-pathogen Lecture Immunology, Infectious disease Monday, April 22, 1996 - 9:07am

Some organisms have evolved ways of evading or subverting the body's defenses.

Modeling the Regulatory Switches of the Pitx1 Gene in Stickleback Fish /biointeractive/modeling-regulatory-switches-pitx1-gene-stickleback-fish Activity Mechanisms of evolution, Gene regulation, Skin, muscles, and bones Monday, April 22, 2013 - 9:59am

A hands-on activity in which students interpret molecular diagrams and build physical models of eukaryotic gene regulation.

Using Genetic Crosses to Analyze a Stickleback Trait /biointeractive/using-genetic-crosses-analyze-stickleback-trait Activity Evolution of populations, Mendelian inheritance, Skin, muscles, and bones Monday, April 22, 2013 - 10:04am

A hands-on activity in which students analyze the results of genetic crosses between stickleback fish with different traits.

Bacterial ID Virtual Lab App /biointeractive/bacterial-id-virtual-lab-app Apps and eBooks Bacteria, Bioinformatics, Infectious disease, Biotechnology Thursday, June 30, 2011 - 1:25pm

Learn about the science and techniques used to identify different types of bacteria based on their DNA sequences

Click and Learn App /biointeractive/click-and-learn-app Apps and eBooks Evolution, Ecology, Genetics, Earth and Environment, Organismal Biology, Biology of Cells Saturday, July 2, 2011 - 1:31pm

Interactively explore topics in biology with the Click and Learn app. Now available from the Apple App Store, Google Play, and Amazon Apps!

Deep History of Life on Earth /biointeractive/deep-history-life-earth Click & Learn Paleobiology, Earth history Tuesday, April 24, 2012 - 1:51pm

The record of life on Earth stretches over 3 billion years. Deep time and Earth history are keys to understanding the present.

Paleoclimate: A History of Change /biointeractive/paleoclimate-history-change Click & Learn Earth history, Climate Wednesday, April 24, 2013 - 1:54pm

Earth's climate is a complex system controlled by many factors. This Click and Learn will examine the two most important factors: solar radiation and the composition of Earth's atmosphere. Worksheet available in Spanish.

Geological History of Oxygen /biointeractive/geological-history-oxygen Click & Learn Chemistry, Earth processes, Earth history Wednesday, April 24, 2013 - 1:58pm

Explore the changes in oxygen levels throughout Earth’s history and discover their impact on life.

BioInteractive Video Podcasts /biointeractive/biointeractive-video-podcasts Wednesday, May 8, 2013 - 8:56am

Watch our lectures, video extras, and short films via our podcast channel.

Finding the Crater /biointeractive/finding-the-crater Activity Earth history, Statistics and math, History of science Thursday, May 9, 2013 - 10:14am

This hands-on activity requires students to “visit” different K-T boundary sites.

Teacher Guide: Holiday Lectures on Science - 1997 /biointeractive/teacher-guide-holiday-lectures-science-1997 Teacher Guide Neuroscience, Cell signaling Tuesday, May 20, 1997 - 9:59am

A guide written for teachers to accompany the 1997 Holiday Lectures on Science.

Teacher Guide: Holiday Lectures on Science - 1998 /biointeractive/teacher-guide-holiday-lectures-science-1998 Teacher Guide DNA, Circulation Wednesday, May 20, 1998 - 10:47am

A guide written for teachers to accompany the 1998 Holiday Lectures on Science.

Teacher Guide: Holiday Lectures on Science - 1999 /biointeractive/teacher-guide-holiday-lectures-science-1999 Teacher Guide Virus, Bacteria, Infectious disease Thursday, May 20, 1999 - 10:50am

A guide written for teachers to accompany the 1999 Holiday Lectures on Science.

Teacher Guide: Holiday Lectures on Science - 2000 /biointeractive/teacher-guide-holiday-lectures-science-2000 Teacher Guide DNA, Behavior Saturday, May 20, 2000 - 10:56am

A guide written for teachers to accompany the 2000 Holiday Lectures on Science.

EarthViewer Data Files /biointeractive/earthviewer-data-files Activity Earth processes, Earth history, Climate, Statistics and math Wednesday, May 23, 2012 - 8:21am

Summaries and links to the data files used to create the charts in EarthViewer, including the APK file to manually install the app.

Earthviewer Video Tour /biointeractive/earthviewer-video-tour Clip Wednesday, June 13, 2012 - 12:50pm

Watch this 30-second tour of how EarthViewer works and how to use the interface.

Got Lactase? Blood Glucose Data Analysis /biointeractive/got-lactase-blood-glucose-data-analysis Activity Biochemistry, Gene regulation, Nutrition, Statistics and math Friday, June 14, 2013 - 2:32pm

Students interpret the results of two different tests for lactase persistence.

Milk—How Sweet Is It? /biointeractive/milk-how-sweet-it Activity Mechanisms of evolution, Nutrition, Scientific methodology Wednesday, October 22, 2014 - 2:37pm

In this lab, students test different samples to see which ones contain the lactase enzyme. Also available in Spanish.

Battling Vector-Borne Diseases: Factors That Affect the Mosquito Life Cycle /biointeractive/battling-vector-borne-diseases-factors-affect-mosquito-life-cycle Activity Behavior, Infectious disease, Scientific methodology Friday, July 9, 2010 - 3:17pm

In this activity, students rear mosquitoes in chambers and test variables that might affect the life cycle of the mosquito. Resources are also available in Spanish.

West Nile Virus: Vectors and Hosts Game /biointeractive/west-nile-virus-vectors-and-hosts-game Activity Infectious disease Thursday, July 31, 2014 - 12:27pm

Play the West Nile virus game to learn how the virus spreads and how the outcome changes depending on the species that is infected. Resources are also available in Spanish.

Medicine in the Genomic Era /biointeractive/medicine-genomic-era Lecture Genomics, Genetic basis of disease, Neuroscience, Cancer Friday, August 2, 2013 - 8:47am

In the 2013 Holiday Lectures on Science, leading medical researchers explain how advances in genomics are revolutionizing their work, leading to a better understanding of disease and to improved treatments.

Genetic Mutations and Disease /biointeractive/genetic-mutations-and-disease Poster Genetic basis of disease, Neuroscience, Developmental biology, Cancer, Cell growth and division Wednesday, August 21, 2013 - 2:10pm

The poster for the 2013 Holiday Lectures on Science, Medicine in the Genomic Era, illustrates the difference between germline and somatic cell mutations.

Plate Tectonics /biointeractive/plate-tectonics Animation Geology, Earth processes Monday, September 17, 2012 - 8:53am

Plate tectonics is the unifying theory of Earth science.

Meet Chris Walsh /biointeractive/meet-chris-walsh Clip Genomics, Developmental biology, Neuroscience Friday, September 20, 2013 - 2:07pm

Dr. Walsh is an HHMI investigator whose research focuses on understanding the genes involved in the development and function of the human brain.

Meet Charles Sawyers /biointeractive/meet-charles-sawyers Clip Genomics, Cancer Friday, September 20, 2013 - 2:14pm

Dr. Sawyers is an HHMI investigator who has contributed to the development of drugs that target leukemia and prostate cancer. 

Diet and the Evolution of Salivary Amylase /biointeractive/diet-and-evolution-salivary-amylase Activity Evolution of populations, Biochemistry, Nutrition Saturday, October 22, 2011 - 1:55pm

Students explore the effects of different diets on the evolution of an enzyme that breaks down starch.

Pedigrees and the Inheritance of Lactose Intolerance /biointeractive/pedigrees-and-inheritance-lactose-intolerance Activity Mendelian inheritance, DNA, Nutrition Wednesday, October 22, 2014 - 2:06pm

Students explore the genetic changes associated with lactose tolerance/intolerance and how the trait is inherited in families. Also available in Spanish.

The Origin of Species: The Making of a Theory /biointeractive/the-origin-of-species-the-making-of-a-theory Short Film Evolutionary theory, History of science, Science and society Tuesday, November 12, 2013 - 8:16am

The epic voyages of Darwin and Wallace led each to independently discover the natural origin of species and to formulate the theory of evolution by natural selection. Also available in Spanish.

The Origin of Species: The Beak of the Finch /biointeractive/the-origin-of-species-the-beak-of-the-finch Short Film Speciation, Phylogeny and classification, Natural selection, Behavior Tuesday, November 12, 2013 - 8:38am

Four decades of research on finch species that live only on the Galápagos Islands illuminate how species form and multiply. Also available in Spanish.

The Origin of Species: Lizards in an Evolutionary Tree /biointeractive/the-origin-of-species-lizards-in-an-evolutionary-tree Short Film Speciation, Phylogeny and classification, DNA, Behavior Tuesday, November 12, 2013 - 8:42am

In the Caribbean islands, adaptation to several common habitats has led to a large adaptive radiation with interesting examples of convergent evolution. Also available in Spanish.

The Double Helix /biointeractive/double-helix Short Film Nucleic acids, DNA, History of science Tuesday, November 12, 2013 - 9:18am

The Double Helix is the story of the scientists and evidence involved in one of the most important scientific quests of the 20th century: the discovery of the structure of DNA. Also available in Spanish.

Sorting Finch Species /biointeractive/sorting-finch-species Click & Learn Speciation, Behavior Monday, November 18, 2013 - 9:28am

Finches discriminate between members of their own species and those of a closely related species based on song and appearance.

Lactose Intolerance: Fact or Fiction /biointeractive/lactose-intolerance-fact-or-fiction Activity Mechanisms of evolution, Biochemistry, Gene regulation, Nutrition Wednesday, November 27, 2013 - 9:03am

Students evaluate and discuss several statements about lactose intolerance and evolution before and after watching the film. Also available in Spanish.

Film Guides: The Double Helix /biointeractive/film-guides-double-helix Film Guide Nucleic acids, DNA, History of science, Biotechnology Thursday, January 2, 2014 - 12:20pm

The following classroom-ready resources complement The Double Helix. This short film describes the evidence that led James Watson and Francis Crick to the discovery of the double-helical structure of DNA and how the structure immediately revealed how genetic information is stored and inherited.

The Animated Life of A. R. Wallace /biointeractive/animated-life-ar-wallace Animated Short Evolutionary theory, History of science Saturday, January 4, 2014 - 3:02pm

This animated short video illustrates the life of Alfred Russel Wallace, who independently formulated the theory of evolution by natural selection at the same time as Charles Darwin.

Film Guides: The Origin of Species: The Beak of the Finch /biointeractive/film-guides-origin-species-beak-finch Film Guide Speciation, Biodiversity, Animals, Behavior Tuesday, January 14, 2014 - 7:37pm

The following classroom-ready resources complement The Origin of Species: The Beak of the Finch. By following four decades of research on the finches of the Galápagos islands, the film illustrates how geography and ecology can drive the evolution of new species.

Film Guides: The Origin of Species: Lizards in an Evolutionary Tree /biointeractive/film-guides-the-origin-of-species-lizards-in-an-evolutionary-tree Film Guide Speciation, Biodiversity, Animals, Behavior Wednesday, January 15, 2014 - 7:48pm

The following classroom-ready resources complement The Origin of Species: Lizards in an Evolutionary Tree. Research on the anole lizards is enriching our understanding of evolutionary processes, such as adaptation by natural selection, convergent evolution, and the formation of new species. Also available in Spanish.

Submission Guidelines and Terms /biointeractive/submission-guidelines-and-terms Friday, January 17, 2014 - 2:37pm

Guidelines and submission terms for Image of the Week submissions.

Deciphering Tangled Connections, Neuron by Neuron /biointeractive/deciphering-tangled-connections-neuron-neuron Image of the Week Neuroscience, Biotechnology Friday, January 17, 2014 - 2:44pm

One approach to understanding the brain is to reconstruct the shapes and connections of individual neurons.

Film Guides: The Origin of Species: The Making of a Theory /biointeractive/film-guides-origin-species-making-theory Film Guide Evolutionary theory, History of science Tuesday, January 28, 2014 - 7:39pm

The following classroom-ready resources complement The Origin of Species: The Making of a Theory, which tells the story of the epic adventures of Charles Darwin and Alfred Russel Wallace and of the evidence they gathered for the theory of evolution by means of natural selection

Pearls or Stink Bug Eggs? /biointeractive/pearls-or-stink-bug-eggs Image of the Week Animals, Developmental biology Monday, February 3, 2014 - 12:46pm

A group of 14 stink bug eggs attached to the underside of a poplar leaf.

Image of the Week — Frequently Asked Questions /biointeractive/image-week-frequently-asked-questions Wednesday, February 5, 2014 - 1:40pm

Information on how to submit your images to Image of the Week.

Feeding a Hungry Heart /biointeractive/feeding-hungry-heart Image of the Week Skin, muscles, and bones, Circulation Tuesday, February 11, 2014 - 11:02am

An intricate three-dimensional network of blood vessels nourishes the heart.

Gleevec Inhibits Cancer-Causing Kinase BCR-ABL /biointeractive/gleevec-inhibits-cancer-causing-kinase-bcr-abl Animation Biochemistry, Proteins, Genetic basis of disease, Cell signaling, Cancer Friday, February 14, 2014 - 1:28pm

The drug Gleevec binds to and inactivates BCR-ABL, a mutant kinase that causes chronic myeloid leukemia. 

Gleevec-Resistant Form of Kinase BCR-ABL /biointeractive/gleevec-resistant-form-kinase-bcr-abl Animation Biochemistry, Proteins, Genetic basis of disease, Cell signaling, Cancer Friday, February 14, 2014 - 1:32pm

Mutations in the BCR-ABL gene can cause resistance to Gleevec, but another drug, dasatinib, can be used instead.

Let's Stick Together /biointeractive/lets-stick-together Image of the Week Biodiversity, Animals, Cell structure Monday, February 17, 2014 - 10:17am

Sponges feed themselves through chambers of specialized cells.

Evolution in Action: Data Analysis /biointeractive/evolution-in-action-data-analysis Activity Speciation, Natural selection, Evolution of populations, Statistics and math Wednesday, February 19, 2014 - 2:52pm

These two activities support the film The Origin of Species: The Beak of the Finch. They provide students with the opportunity to analyze data collected by Princeton University evolutionary biologists Peter and Rosemary Grant.

Wallace's Golden Birdwing Butterfly /biointeractive/wallaces-golden-birdwing-butterfly Image of the Week Speciation, Biodiversity, Animals, History of science Monday, February 24, 2014 - 1:53pm

The golden birdwing provided a striking clue to the natural origin of species.

The Making of a Fly's Brain /biointeractive/making-flys-brain Image of the Week Neuroscience, Stem cells Tuesday, March 4, 2014 - 7:29am

The developing brain needs a constant source of new cells as it builds the circuits that will control behavior.

The Eye of a Red-eyed Tree Frog at Rest /biointeractive/eye-red-eyed-tree-frog-rest Image of the Week Animals, Developmental biology Friday, March 7, 2014 - 11:32am

Many animals have a third eyelid called a nictitating membrane that protects the eye.

Anole Lizards: An Example of Speciation /biointeractive/anole-lizards-example-speciation Animation Mechanisms of evolution, Speciation, Behavior Tuesday, March 11, 2014 - 12:32pm

This animation features the anole lizards as an example of how a single species can split and multiply into many different species with distinct traits.

The BioInteractive Team /biointeractive/the-biointeractive-team Thursday, March 13, 2014 - 2:42pm

HHMI’s BioInteractive website provides a wide array of free science education resources for the classroom. They are produced by a core team of scientist educators, graphic artists, video producers, and outreach professionals working in close collaboration with science teachers and undergraduate educators, scientists, film producers, animators, and programmers

See Your Inner Primate /biointeractive/see-your-inner-primate Image of the Week Human evolution, Biodiversity, Neuroscience Monday, March 17, 2014 - 11:29am

The eye of a chimpanzee views the world in living color.

How the Sea Anemone Gets Its Tentacles /biointeractive/how-sea-anemone-gets-its-tentacles Image of the Week Animals, Developmental biology Monday, March 17, 2014 - 11:57am

The young starlet sea anemone forms tentacles by cell division, migration, and shape changes.   

Sizing Up the Brain Gene By Gene /biointeractive/sizing-brain-gene-gene Lecture Genomics, Genetic basis of disease, Developmental biology, Neuroscience Thursday, March 20, 2014 - 9:43am

Recent advances in DNA sequencing technology have led to a better understanding of the many genes that play a role in brain development.

Cancer As a Genetic Disease /biointeractive/cancer-genetic-disease Lecture Proteins, Genetic basis of disease, Cell signaling, Cancer Thursday, March 20, 2014 - 9:52am

Understanding that cancer is caused by mutations in genes that regulate cell proliferation has led to the development of targeted drug therapies.

Decoding the Autism Puzzle /biointeractive/decoding-autism-puzzle Lecture Genomics, Genetic basis of disease, Neuroscience Thursday, March 20, 2014 - 9:55am

Over the past decade, the application of advanced DNA sequencing techniques has greatly increased our understanding of the genetic basis of autism.

From Cancer Genomics to Cancer Drugs /biointeractive/cancer-genomics-cancer-drugs Lecture Genomics, Immunology, Cell signaling, Cancer Thursday, March 20, 2014 - 10:01am

Genetic data from a large number of tumor types reveal commonly mutated genes and uncover connections between different types of cancer.

Genomic Medicine, Autism, and Cancer /biointeractive/genomic-medicine-autism-and-cancer Lecture Genomics, Genetic basis of disease, Neuroscience, Cancer Thursday, March 20, 2014 - 10:05am

A student discussion with the lecturers of the 2013 Holiday Lectures on Science.

Dog Genomics and Dogs as Model Organisms /biointeractive/dog-genomics-and-dogs-model-organisms Lecture Artificial selection, Genomics, Bioinformatics Thursday, March 20, 2014 - 10:10am

Dr. Elinor Karlsson discusses her work with dogs as a model organism for genomic studies.

Interview with Christopher Walsh, MD, PhD /biointeractive/interview-christopher-walsh-md-phd Interview Genomics, Neuroscience, Careers in science Friday, March 21, 2014 - 10:48am

Dr. Walsh recalls his childhood as one of eight siblings, discovering science in college, and the role of genomics in studying autism.

Interview with Charles Sawyers, MD /biointeractive/interview-charles-sawyers-md Interview Genomics, Cancer, Careers in science Friday, March 21, 2014 - 10:55am

Dr. Sawyers describes how he became interested in science during medical school, and offers advice to science students.

Interview with Minna Balbas /biointeractive/interview-minna-balbas Interview Cancer, Scientific methodology Friday, March 21, 2014 - 11:25am

Ms. Balbas discusses her early interest in medicine, her path to becoming a researcher, and her best day in the lab.

Interview with Madelen Diaz /biointeractive/interview-madelen-diaz Interview Neuroscience, Careers in science Friday, March 21, 2014 - 11:32am

Ms. Diaz discusses her family's emphasis on academics, how she discovered neuroscience, and describes a typical day in the lab.

Interview with Jenny Yawei Yang /biointeractive/interview-jenny-yawei-yang Interview Genomics, Neuroscience, Careers in science Friday, March 21, 2014 - 12:20pm

Ms. Yang describes what it was like growing up in a family filled with medical doctors, discusses her MD-PhD program, and provides advice to high school students interested in science.

BioInteractive at NSTA in Boston /biointeractive/biointeractive-nsta-boston Saturday, March 22, 2014 - 11:01am

BioInteractive will be in Boston on April 3–5 for the National Science Teachers Association meeting. Stop by booth #843, join us for HHMI’s Night at the Movies, and participate in hands-on workshops featuring free classroom-ready activities!

Explore Your Inner Animals /biointeractive/explore-your-inner-animals Click & Learn Paleobiology, Human evolution, Animals, Skin, muscles, and bones Tuesday, March 25, 2014 - 7:57am

This interactive explores different anatomical features of the human body and what they reveal about the evolutionary history we share with other organisms, including earlier, long-extinct species.

Great Transitions: The Origin of Tetrapods /biointeractive/great-transitions-origin-tetrapods Short Film Mechanisms of evolution, Paleobiology, Skin, muscles, and bones, Scientific methodology Friday, March 28, 2014 - 9:05am

One of the most exciting discoveries in the long history of fossil exploration is Tiktaalik, a creature with a mix of features common to fish and four-legged animals, or tetrapods.

Revealing the Inner Fish /biointeractive/revealing-inner-fish Image of the Week Phylogeny and classification, Skin, muscles, and bones Monday, March 31, 2014 - 2:47pm

The fins of the scalyhead sculpin are related to our arms.

Using DNA to Explore Lizard Phylogeny /biointeractive/using-dna-explore-lizard-phylogeny Activity Phylogeny and classification, Biodiversity, Bioinformatics, DNA, Behavior, Scientific methodology Wednesday, April 2, 2014 - 2:59pm

This activity supports the film The Origin of Species: Lizards in an Evolutionary Tree. Students are guided to sort the lizard species by appearance, then generate a phylogenetic tree using the lizards’ DNA sequences to evaluate whether species that appear similar are closely related to each other.

Digging Your Inner Fish /biointeractive/digging-your-inner-fish Image of the Week Paleobiology, Earth history, Skin, muscles, and bones, Scientific methodology Monday, April 7, 2014 - 9:58pm

Tiktaalik roseae, also known as the “fishapod,” is an animal that lived about 375 million years ago, with features of fish and four-legged animals.

Beaks As Tools: Selective Advantage in Changing Environments /biointeractive/beaks-as-tools-selective-advantage-in-changing-environments Activity Speciation, Biodiversity, Behavior, Scientific methodology Thursday, April 10, 2014 - 8:57am

This classroom experiment supports the film The Origin of Species: The Beak of the Finch. Students collect and analyze data to learn why even slight variations in beak size can make the difference between life and death.

Earth Systems Activity /biointeractive/earth-systems-activity Activity Chemistry, Climate, Human impacts, Science and society Friday, April 11, 2014 - 3:12pm

This activity guides students through building a conceptual model of how carbon dioxide affects Earth's climate

EarthViewer Climate Guide Activity /biointeractive/earthviewer-climate-guide-activity Activity Climate, Human impacts, Science and society Friday, April 11, 2014 - 3:36pm

This student worksheet highlights climate concepts in the EarthViewer app.

Your Armored Reptile /biointeractive/your-armored-reptile Image of the Week Animals, Skin, muscles, and bones Sunday, April 13, 2014 - 2:33pm

The Cape Cliff lizard sports a bony body armor.

Film Guides: The Origin of Tetrapods /biointeractive/film-guides-origin-tetrapods Film Guide Mechanisms of evolution, Paleobiology, Earth history, Skin, muscles, and bones Monday, April 21, 2014 - 9:32am

The following classroom-ready resources complement Great Transitions: The Origin of Tetrapods, which tells the story of the discovery of Tiktaalik, a creature with features common to fish and four-legged animals, or tetrapods.

The Making of a Theory—Fact or Fiction /biointeractive/making-theory-fact-or-fiction Activity Evolutionary theory, History of science Monday, April 21, 2014 - 10:20am

This activity supports the viewing of the film The Origin of Species: The Making of a Theory. Before and after watching the film, students discuss and evaluate several statements about Charles Darwin, Alfred Russel Wallace, and the specific evidence that led each of them to the theory of evolution by natural selection.

Grasping Your Inner Monkey /biointeractive/grasping-your-inner-monkey Image of the Week Human evolution, Skin, muscles, and bones, Behavior Monday, April 21, 2014 - 4:42pm

The shape of our hands comes from tree-dwelling ancestors.

These Limbs Are Made for Walkin'... /biointeractive/these-limbs-are-made-walkin Image of the Week Animals, Gene regulation, Developmental biology Monday, April 28, 2014 - 8:58am

... but that's not all they'll do. Several genes determine the diverse shapes and functions of crustacean appendages. 

Development of the Cerebral Cortex /biointeractive/development-cerebral-cortex Animation Developmental biology, Neuroscience, Cell growth and division Wednesday, April 30, 2014 - 11:09am

Most of the neurons of the cerebral cortex arise from progenitor cells that undergo repeated cell division.

Autism and the Structure and Function of Synapses /biointeractive/autism-structure-function-synapses Animation Genetic basis of disease, Neuroscience, Cell structure, Cell signaling Wednesday, April 30, 2014 - 11:21am

Genes associated with autism affect the structure and function of neuronal synapses.

Cancer and Cell Fate in the Intestinal Epithelium /biointeractive/cancer-and-cell-fate-intestinal-epithelium Animation Nutrition, Cancer, Cell growth and division Wednesday, April 30, 2014 - 11:30am

Disrupting the normal processes of differentiation and maturation of the intestinal epithelial cells can lead to cancer. Also available in Spanish.

CLARITY—Cutting Edge Microscopy for Brain Imaging /biointeractive/clarity-cutting-edge-microscopy-brain-imaging Clip Neuroscience, Scientific methodology Wednesday, April 30, 2014 - 1:21pm

A new technique for making the brain transparent provides extremely detailed views of groups of neurons.

Meet Dante—A Young Boy with Hemimegalencephaly /biointeractive/meet-dante-young-boy-hemimegalencephaly Clip Genetic basis of disease, Developmental biology, Neuroscience Wednesday, April 30, 2014 - 1:27pm

Dante is a healthy 10-year-old boy who has had half his cerebral cortex surgically removed to treat his seizures.

The Search for Genetic Mutations that Cause Autism /biointeractive/search-genetic-mutations-cause-autism Clip Genomics, Developmental biology, Neuroscience Wednesday, April 30, 2014 - 1:32pm

Dr. Christopher Walsh discusses how genomic science has made enormous contributions to our understanding of the genetic causes of autism.

DNA Sequence Technology Improves Cancer Treatment /biointeractive/dna-sequence-technology-improves-cancer-treatment Clip DNA, Genomics, Cancer, Biotechnology Wednesday, April 30, 2014 - 1:36pm

Dr. Charles Sawyers discusses how the identification of most cancer genes could transform cancer into a chronic disease.

Dante's Story /biointeractive/dantes-story Clip Genetic basis of disease, Developmental biology, Neuroscience Wednesday, April 30, 2014 - 1:41pm

Dante is a 10-year-old boy born with hemimegalencephaly—an enlargement of half his brain.

Good Moms Come in All Shapes and Sizes /biointeractive/good-moms-come-all-shapes-and-sizes Image of the Week Animals, Behavior Monday, May 5, 2014 - 1:31pm

Female peacock spiders stay with their young in an egg sac until they can fend for themselves. 

Pulse Chase Primer: The Meselson-Stahl Experiment /biointeractive/pulse-chase-primer-the-meselson-stahl-experiment Activity DNA, History of science, Scientific methodology Tuesday, May 6, 2014 - 8:35am

This activity can be used in conjunction with the short film The Double Helix. It introduces students to the classic experiment by Matthew Meselson and Franklin Stahl, which revealed that DNA replication follows the semiconservative model.

Holding on to Your Mother /biointeractive/holding-your-mother Image of the Week Human evolution, Biodiversity, Animals, Behavior Monday, May 12, 2014 - 2:51pm

Infant lemurs hitch a ride through the forest by holding on to their mother’s tummy or riding piggyback.

It's a Fishapod! /biointeractive/its-fishapod Article Paleobiology, Mechanisms of evolution Tuesday, May 13, 2014 - 8:11am

This article by Sean B. Carroll tells the story of the search for and discovery of Tiktaalik, an animal with a mix of fish and tetrapod features—a fishapod! It supplements the short film Great Transitions: The Origin of Tetrapods, starring Neil Shubin.

Young Students Recognize a Transitional Fossil /biointeractive/young-students-recognize-transitional-fossil Clip Paleobiology, Mechanisms of evolution Thursday, May 15, 2014 - 10:04am

Neil Shubin brought the fossil of Tiktaalik to his daughter’s first grade class to see what the students would make of it.

Perfect Daughters /biointeractive/perfect-daughters Image of the Week Gene expression, Developmental biology, Cell growth and division Monday, May 19, 2014 - 2:21pm

Chromosomes change form as a cell divides to ensure that each daughter cell gets a full, intact copy of the genome.

Discovering the Wallace Line /biointeractive/discovering-wallace-line Activity Evolutionary theory, Biodiversity, Earth processes, History of science Wednesday, May 21, 2014 - 11:28am

This activity supports the HHMI short film The Origin of Species: The Making of a Theory. Students are presented with a map of the Malay Archipelago and some field notebooks with observations of animals. By plotting which animals are found on which island, the students discover the Wallace Line—a sharp boundary that separates distinct Asian and Australian fauna. 

Dengue Virus /biointeractive/dengue-virus 3D Model Virus, Infectious disease Friday, May 23, 2014 - 1:19pm

A 3D model of dengue virus.

Nodamura Virus /biointeractive/nodamura-virus 3D Model Virus, Infectious disease Friday, May 23, 2014 - 1:24pm

A 3D model of nodamura virus.

Rhinovirus /biointeractive/rhinovirus 3D Model Virus, Infectious disease Friday, May 23, 2014 - 1:29pm

A 3D model of rhinovirus, an RNA genome virus that is the main cause of the common cold in humans.

BCR-ABL: ABL Kinase Domain /biointeractive/bcr-abl-abl-kinase-domain 3D Model Proteins, Cancer Friday, May 23, 2014 - 1:33pm

A 3D model of BCR-ABL, an unregulated kinase that causes cancer.

Gleevec-resistant BCR-ABL: ABL Kinase Domain /biointeractive/gleevec-resistant-bcr-abl-abl-kinase-domain 3D Model Proteins, Cancer Friday, May 23, 2014 - 1:37pm

A 3D model of gleevec-resistant BCR-ABL, a mutated form of BCR-ABL.

Adenosine Triphosphate (ATP) /biointeractive/adenosine-triphosphate-atp 3D Model Biochemistry, Respiration, Cancer Friday, May 23, 2014 - 1:43pm

A 3D model of adenosine triphosphate, or ATP.

Imatinib (Gleevec) /biointeractive/imatinib-gleevec 3D Model Biochemistry, Cancer Friday, May 23, 2014 - 1:48pm

A 3D model of imatinib (Gleevec), a drug that mimics ATP and inhibits BCR-ABL.

Dasatinib /biointeractive/dasatinib 3D Model Biochemistry, Cancer Friday, May 23, 2014 - 1:54pm

A 3D model of dasatinib, a drug that can inhibit BCR-ABL and Gleevec-resistant BCR-ABL.


Hunting Down HIV /biointeractive/hunting-down-hiv Image of the Week Virus, Infectious disease Monday, May 26, 2014 - 4:55pm

The human immunodeficiency virus (HIV) is discovered “hiding” between the cells of the gut.

Great Transitions Interactive /biointeractive/great-transitions-interactive Click & Learn Mechanisms of evolution, Paleobiology, Earth history Friday, May 30, 2014 - 2:36pm

The fossils of transitional creatures were key evidence for Darwin’s evolutionary theory, but none had been found when he published On the Origin of Species. Now, there are many examples of such fossils, which clearly show that big evolutionary leaps consist of many smaller steps.

Three-Layer Retina /biointeractive/three-layer-retina Image of the Week Neuroscience, Cell signaling Monday, June 2, 2014 - 12:49pm

The arrangement of cells in the retina reveals how it detects, processes, and relays visual information to the brain.

Howie /biointeractive/howie 3D Model Tuesday, June 3, 2014 - 1:44pm

Howie is BioInteractive's mascot. He's an interactivore.

Dinner Date /biointeractive/dinner-date Image of the Week Animals, Behavior Monday, June 9, 2014 - 3:14pm

The male peacock spider performs a spectacular dance to attract a mate—but the female is not always impressed.

Dengue Fever /biointeractive/dengue-fever Image of the Week Virus, RNA, Infectious disease Monday, June 16, 2014 - 10:01am

A 3D model of the dengue virus reveals a shape like a soccer ball with an outer coating of glycoproteins.

A Flower That Fits the Bill /biointeractive/flower-fits-bill Image of the Week Mechanisms of evolution, Biodiversity, Skin, muscles, and bones Monday, June 16, 2014 - 10:32am

The bill of the buff-tailed sicklebill hummingbird is perfectly shaped to collect nectar from deep within the Centropogon flower.

Fact Patterns: A Film Guide /biointeractive/fact-patterns-film-guide Activity Evolutionary theory, History of science Wednesday, June 18, 2014 - 3:41pm

Students are challenged to identify “fact patterns,” or patterns that emerge from a collection of different facts and observations, and draw conclusions about what they suggest. Also available in Spanish.

Seeing Fireworks /biointeractive/seeing-fireworks Image of the Week Neuroscience, Cell signaling Friday, June 20, 2014 - 5:08pm

A unique group of cells in the eye’s retina specifically detects the upward motion of objects, such as a ball thrown in the air or…fireworks.

Lizard Evolution Virtual Lab /biointeractive/lizard-evolution-virtual-lab Virtual Lab Speciation, Populations, Biodiversity, Behavior Friday, June 20, 2014 - 5:17pm

In the Lizard Evolution Virtual Lab students explore the evolution of the anole lizards in the Caribbean by collecting and analyzing their own data.  

The Guide: A Biologist in Gorongosa /biointeractive/guide-biologist-gorongosa Short Film Conservation biology, Biodiversity, Human impacts, Careers in science, Science and society Monday, July 7, 2014 - 9:20am

Set against the restoration of war-torn Gorongosa National Park in Mozambique, The Guide tells the story of a young man from the local community who discovers a passion for science after meeting world-renowned biologist E.O. Wilson.  Also available in Spanish.

Teacher Guide: Math and Statistics /biointeractive/teacher-guide-math-and-statistics Teacher Guide Statistics and math Tuesday, August 12, 2014 - 8:48am

Topics include measures of average (mean, median, and mode), variability (range and standard deviation), uncertainty (standard error and 95% confidence interval), Chi-square analysis, student t-test, Hardy-Weinberg equation, frequency calculations, and more. 

Gorongosa: Restoring Mozambique’s National Treasure /biointeractive/gorongosa-restoring-mozambique-s-national-treasure Article Conservation biology, Populations, Human impacts, Science and society Thursday, August 21, 2014 - 9:36am

This article by Gorongosa National Project staff explains the project’s history, mission, and future goals.

Biodiversity in the Age of Humans /biointeractive/biodiversity-age-humans Lecture Paleobiology, Biodiversity, Conservation biology, Earth history, Climate, Human impacts Thursday, August 21, 2014 - 10:33am

Are we witnessing a sixth mass extinction? What factors threaten ecosystems on land and in the sea? What are researchers doing to try to conserve biodiversity and ecosystems?

Gorongosa National Park Interactive Map /biointeractive/gorongosa-national-park-interactive-map Click & Learn Biosphere, Conservation biology, Ecosystems, Communities, Biodiversity, Science and society Friday, August 22, 2014 - 10:00am

This interactive map of Gorongosa National Park allows users to explore different features of the park, including key components of the conservation strategy. 

Biodiversity at Your Fingertips /biointeractive/biodiversity-your-fingertips Image of the Week Biodiversity, Conservation biology, Animals Monday, August 25, 2014 - 12:03pm

Gorongosa National Park is rich in diverse species including some found only in and near the park, like this pygmy chameleon.

Film Guides: The Guide: A Biologist in Gorongosa /biointeractive/film-guides-guide-biologist-gorongosa Film Guide Biodiversity, Conservation biology, Careers in science, Science and society Monday, August 25, 2014 - 3:04pm

The following classroom-ready resources complement The Guide: A Biologist in Gorongosa, which tells the story of Tonga Torcida, a young man coming of age on Mount Gorongosa and in the newly revitalized Gorongosa National Park in Mozambique.

Putting Food on the Table /biointeractive/putting-food-table Image of the Week Biodiversity, Conservation biology, Animals, Behavior Sunday, August 31, 2014 - 12:53pm

Weaver ants labor to carry a live land snail back to their nest in Gorongosa National Park.

The Anthropocene—Human Impact on the Environment /biointeractive/anthropocene-human-impact-environment-0 Poster Biodiversity, Earth history, Climate, Human impacts Thursday, September 4, 2014 - 9:08am

The poster supporting the 2014 Holiday Lectures, Biodiversity in the Age of Humans, illustrates many ways that humans are affecting the earth.

On Their Way Back /biointeractive/their-way-back Image of the Week Biodiversity, Conservation biology, Animals Monday, September 8, 2014 - 11:24am

Zebras on the move in a remote area of Gorongosa National Park in 2006.

Animalcules with Wheels /biointeractive/animalcules-wheels Image of the Week Animals, History of science, Scientific methodology Sunday, September 14, 2014 - 12:58pm

Dutch draper Antonie van Leeuwenhoek (1632–1723) built microscopes that allowed him to observe never-before-seen microorganisms, including this rotifer. He called them “animalcules.”  

Biodiversity Rediscovered /biointeractive/biodiversity-rediscovered Image of the Week Biodiversity, Conservation biology, Animals Monday, September 22, 2014 - 10:11am

Gorongosa’s spiky pillbug had not been seen for 50 years.

Potent Stem Cells /biointeractive/potent-stem-cells Poster Developmental biology, Stem cells, Biotechnology Tuesday, September 23, 2014 - 3:51pm

The poster from the 2006 Holiday Lectures on Science, Potent Biology: Stem Cells, Cloning, and Regeneration, illustrates the role of stem cells during human embryonic development.

Gorongosa Timeline /biointeractive/gorongosa-timeline Click & Learn Conservation biology, Populations, Biodiversity, Science and society Thursday, September 25, 2014 - 9:11am

A highly visual interactive timeline for exploring the history of Gorongosa National Park, from its beginnings as a hunting reserve and decline in the wake of a civil war, to its return to being one of the world’s foremost wildlife treasures and case studies in conservation biology.  

Counting the Chirps of Fall /biointeractive/counting-chirps-fall Image of the Week Animals, Behavior Monday, September 29, 2014 - 10:35am

A close-up view of the sound-producing structure on the wing of a field cricket (Gryllus pennsylvanicus).

Cancer as a Genetic Disease: Video Highlights /biointeractive/cancer-genetic-disease-video-highlights Clip Genetic basis of disease, Cancer, Cell growth and division Monday, September 29, 2014 - 12:23pm

In this video Dr. Charles Sawyers provides an overview of the types of genes that, when mutated, can lead to the development of cancer. Also available in Spanish.

Cancer Discovery Activities /biointeractive/cancer-discovery-activities Activity Bioinformatics, Genetic basis of disease, Cancer Tuesday, September 30, 2014 - 9:17am

These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video featuring researcher Dr. Charles L. Sawyers. Also available in Spanish.

Fish Tales /biointeractive/fish-tales Image of the Week Developmental biology, Stem cells, Cancer Monday, October 6, 2014 - 9:01am

Zebrafish blood is generated from stem cells located in the tail region of fish embryos and later from stem cells located in the kidney of the adult fish.

Mapping Genes to Traits in Dogs Using SNPs /biointeractive/mapping-genes-traits-dogs-using-snps Activity Artificial selection, Genomics, Bioinformatics, Statistics and math Thursday, October 9, 2014 - 9:11am

In this hands-on genetic mapping activity students identify single nucleotide polymorphisms (SNPs) correlated with different traits in dogs.

Holiday Lecture 2004 Update—Jeff Friedman /biointeractive/holiday-lecture-2004-update-jeff-friedman Clip Genomics, Nutrition, Behavior Friday, October 10, 2014 - 11:34am

HHMI investigator Jeff Friedman provides an update to his 2004 lectures on obesity.

Seeing Single Molecules /biointeractive/seeing-single-molecules Image of the Week Chemistry, Bacteria, Scientific methodology Monday, October 13, 2014 - 11:33am

Pushing the limits of light microscopy to the nanoscale, new technology allows visualization of single proteins in cells.

Animated Life: Seeing the Invisible /biointeractive/seeing-the-invisible Animated Short Animals, Bacteria, Protists, Cell signaling, History of science Monday, October 20, 2014 - 1:22pm

This animated feature celebrates 17th-century citizen-scientist Antonie van Leeuwenhoek, whose discoveries of microbes changed our view of the biological world. Also available in Spanish.

Secret of Coral-Reef Survival /biointeractive/secret-coral-reef-survival Image of the Week Biodiversity, Protists, Animals Monday, October 20, 2014 - 2:52pm

Reef-building corals depend on brown-colored symbiotic algae for survival.

Double, Double, Toil and Trouble /biointeractive/double-double-toil-and-trouble Image of the Week Animals, Developmental biology Monday, October 27, 2014 - 9:57am

Two views of a late pupa of an unidentified midge species (family Chironomidae).

Reading Primary Sources: Darwin and Wallace /biointeractive/reading-primary-sources-darwin-and-wallace Activity Evolutionary theory, History of science, Scientific methodology Wednesday, October 29, 2014 - 9:01am

This activity serves as a supplement to the HHMI short film The Origin of Species: The Making of a Theory. Students read and analyze excerpts from texts written by Charles Darwin and Alfred Russel Wallace and answer questions about the information presented, developing their nonfiction reading comprehension.

One Bone, Two Bones... /biointeractive/one-bone-two-bones Image of the Week Paleobiology, Skin, muscles, and bones, Developmental biology Monday, November 3, 2014 - 2:17pm

This short-tailed fruit bat embryo shows a pattern of bones in its limbs characteristic of all tetrapods: one bone, two bones, lots of bones, digits. 

Piecing Together Our Past /biointeractive/piecing-together-our-past Image of the Week Paleobiology, Human evolution, History of science Monday, November 10, 2014 - 2:31pm

The skull of Zinjanthropus is one of the first early hominid fossils found in Africa and provides essential clues in the story of human evolution.

Coral Bleaching /biointeractive/coral-bleaching Animation Evolution of populations, Animals, Protists, Climate, Photosynthesis Tuesday, November 11, 2014 - 8:49am

Zoom into a coral reef and discover photosynthetic algae inside the coral’s cells. Reef-building corals rely on these symbionts for their survival.

BCR-ABL: Cancer Protein Structure and Function /biointeractive/bcr-abl-cancer-protein-structure-and-function Click & Learn Proteins, Biochemistry, Cancer Tuesday, November 11, 2014 - 1:33pm

This Click and Learn describes how understanding the structure of the BCR-ABL kinase led to the development of an effective treatment for chronic myeloid leukemia.

Have Your Larva and Eat It Too /biointeractive/have-your-larva-and-eat-it-too Image of the Week Biodiversity, Animals, Developmental biology Monday, November 17, 2014 - 1:07pm

During the larval stage, the Nemertean worm develops inside a hollow sac from which the juvenile eventually emerges, rupturing the sac and then eating the remains.

Liz Hadly Tracks the Impact of Climate Change in Yellowstone /biointeractive/liz-hadly-tracks-the-impact-of-climate-change-in-yellowstone Scientists at Work Ecosystems, Communities, Populations, Biodiversity, Climate, Human impacts Wednesday, November 19, 2014 - 10:33am

Ecosystems in the world-famous national park are threatened by warming temperatures.

Anthony Barnosky and Kaitlin Maguire Measure Mammal Extinctions at the John Day Fossil Beds /biointeractive/anthony-barnosky-and-kaitlin-maguire-measure-mammal-extinctions-at-the-john-day Scientists at Work Paleobiology, Biodiversity, Earth history, Scientific methodology Wednesday, November 19, 2014 - 10:43am

Prehistoric extinction rates are calculated from fossil data in a paleodatabase and compared to today’s extinction rate.

Stickleback Evolution Virtual Lab App /biointeractive/stickleback-evolution-virtual-lab-app Apps and eBooks Mechanisms of evolution, Evolution of populations, Paleobiology, Gene regulation Thursday, November 20, 2014 - 4:20pm

App version of the popular virtual lab, introducing you to the science and techniques used to analyze the threespine stickleback fish.

The Eukaryotic Cell Cycle and Cancer /biointeractive/eukaryotic-cell-cycle-and-cancer Click & Learn Genetic basis of disease, Cancer, Cell growth and division, Cell signaling Friday, November 21, 2014 - 3:22pm

Explore the phases, checkpoints, and protein regulators of the cell cycle in this highly interactive Click and Learn and find out how mutated versions of these proteins can lead to the development of cancer. Also available in Spanish.

Your Turkey’s Ancestors /biointeractive/your-turkey-s-ancestors Image of the Week Paleobiology, Animals Monday, November 24, 2014 - 9:33pm

A reconstruction of Anchiornis huxleyi, a feathered dinosaur that is part of the ancestral lineage of birds.

Attacking AIDS from Within /biointeractive/attacking-aids-within Image of the Week Virus, Immunology, Infectious disease Monday, December 1, 2014 - 9:06pm

Killer T-cells captured in the act of destroying HIV-infected cells.

Vertebrate Circulatorium /biointeractive/vertebrate-circulatorium Click & Learn Mechanisms of evolution, Animals, Circulation Friday, December 5, 2014 - 9:08am

Compare and contrast the anatomy of the heart and the circulatory systems of major vertebrate groups and gain insights into their evolution.

Seeing Single Molecules Move /biointeractive/seeing-single-molecules-move Animation Proteins, DNA, Gene regulation, Biotechnology Monday, December 8, 2014 - 10:53am

Single-molecule analysis using super-resolution microscopes reveals that transcription factors are not usually found bound to their binding sites on DNA.

Single Molecules on the Move /biointeractive/single-molecules-move Image of the Week DNA, Gene regulation, Scientific methodology Monday, December 8, 2014 - 3:55pm

Using super-resolution microscopes, scientists have uncovered how single protein molecules behave, and the results are astonishing.

Great Transitions: The Origin of Humans /biointeractive/great-transitions-origin-humans Short Film Mechanisms of evolution, Paleobiology, Human evolution, Skin, muscles, and bones Monday, December 8, 2014 - 9:33pm

Which traits distinguish humans from other primates? When and where did these traits evolve? Analysis of the major fossil finds from Africa, dating back to 4.4 million years ago, provides answers to these questions and reveals the history of our evolutionary origins. Also available in Spanish.

Putting Crocs on the Map /biointeractive/putting-crocs-map Image of the Week Biodiversity, Conservation biology Monday, December 15, 2014 - 3:09pm

One of the largest populations of Nile crocodiles in Africa congregates on the beaches of Lake Urema in Gorongosa National Park.

Festive Fat Cells /biointeractive/festive-fat-cells Image of the Week Nutrition, Cell structure Friday, December 19, 2014 - 9:57am

Fat is made up of spherical plump cells supplied by a network of blood vessels.

Party Like A Microbe /biointeractive/party-microbe Image of the Week Communities, Bacteria Friday, December 19, 2014 - 10:15am

Fluorescence microscopy reveals bacterial communities in human dental plaque.

The Anatomy of a Sneeze /biointeractive/anatomy-sneeze Image of the Week Virus, Infectious disease Monday, January 5, 2015 - 3:24pm

A germ-spreading sneeze unleashes a shower of large liquid droplets and a moist gas cloud of smaller ones.

The Making of Mass Extinctions /biointeractive/making-mass-extinctions Poster Paleobiology, Biodiversity, Earth history Tuesday, January 6, 2015 - 12:16pm

Discover the environmental factors that caused the five big mass extinctions in Earth’s history and which species they impacted.

The Anthropocene: Human Impact on the Environment /biointeractive/anthropocene-human-impact-environment Click & Learn Biodiversity, Earth history, Climate, Human impacts Tuesday, January 6, 2015 - 12:33pm

Explore key human impacts on the environment and how they have affected Earth’s landscape, ocean, atmosphere, and biodiversity with this engaging interactive. 

Fruit Fly Art /biointeractive/fruit-fly-art Image of the Week Neuroscience, Behavior Monday, January 12, 2015 - 12:10pm

Tracking the flight paths and speeds of fruit flies in a wind tunnel may help design better flying robots.

Host to Thousands /biointeractive/host-thousands Image of the Week Animals, Infectious disease Monday, January 19, 2015 - 5:01pm

A freshwater snail infected with thousands of blood flukes will release the disease-causing parasites into the water where they can infect humans.

Lizard Evolution Virtual Lab App /biointeractive/lizard-evolution-virtual-lab-app Apps and eBooks Mechanisms of evolution, Speciation, Phylogeny and classification, Biodiversity Thursday, January 22, 2015 - 9:17am

The Lizard Evolution Virtual Lab app lets you explore the evolution of the anole lizards in the Caribbean on your iOS device.

The Lone Anole /biointeractive/lone-anole Phenomenal Image Speciation, Biodiversity, Animals, Behavior Monday, January 26, 2015 - 1:24pm

Students explore a photo of an anole lizard as an anchoring phenomenon to explore adaptations and natural selection

Measles Outbreak /biointeractive/measles-outbreak Image of the Week Virus, Immunology, Infectious disease Monday, February 2, 2015 - 4:56pm

The measles virus can spread easily among people who have no immunity against it, as the current outbreak shows.

Pocket Mouse Film With Quiz /biointeractive/pocket-mouse-film-quiz Interactive Video Mechanisms of evolution, Natural selection, Evolution of populations Thursday, February 5, 2015 - 10:24am

Embedded quiz modules test students’ understanding as they watch the short film on the rock pocket mouse—a living example of Darwin’s process of natural selection. Also available in Spanish.

Darwin the Entomologist /biointeractive/darwin-entomologist Image of the Week Evolutionary theory, Animals, History of science Monday, February 9, 2015 - 5:20pm

As a student of divinity at Cambridge University, Charles Darwin was an enthusiastic collector of beetles

Great Transitions: The Origin of Birds /biointeractive/great-transitions-origin-birds Short Film Paleobiology, Mechanisms of evolution, Skin, muscles, and bones, Scientific methodology Thursday, February 12, 2015 - 8:20am

In the second film of the Great Transitions trilogy, paleontologist Julia Clarke takes us on a journey to uncover the evidence that birds descended from dinosaurs. Also available in Spanish.

Film Guides: The Origin of Humans /biointeractive/film-guides-origin-humans Film Guide Paleobiology, Human evolution, Skin, muscles, and bones Friday, February 13, 2015 - 11:03am

The following classroom-ready resources complement Great Transitions: The Origin of Humans, which reveals the history of our evolutionary origins. Also available in Spanish.

A Billion Heartbeats /biointeractive/billion-heartbeats Image of the Week Skin, muscles, and bones, Circulation Friday, February 13, 2015 - 12:48pm

The muscles of the mouse’s heart contract about 600 times per minute, or a billion times in its three-year lifespan.

In A Different Light /biointeractive/different-light Image of the Week Paleobiology, Biodiversity, Animals Monday, February 23, 2015 - 4:05pm

A tree scorpion illuminated with UV light gives off a blue-green glow.

Popped Secret: The Mysterious Origin of Corn /biointeractive/popped-secret-mysterious-origin-corn Short Film Paleobiology, Artificial selection, Plants, Gene regulation Monday, March 2, 2015 - 3:30pm

Where did corn come from? Genetic and archeological data point to what may seem like an unlikely ancestor: a wild Mexican grass called teosinte. Also available in Spanish.

Life and Pi /biointeractive/life-and-pi Image of the Week Ecosystems, Protists, Statistics and math Monday, March 9, 2015 - 4:05pm

Many groups of organisms, including some diatoms, are radially symmetrical, and look like circles when seen end on. 

Popping a Kernel /biointeractive/popping-kernel Image of the Week Artificial selection, Plants Monday, March 16, 2015 - 4:14pm

When heated to a temperature of around 180°C, corn bursts open with a “pop” in mere hundredths of seconds.

Learning from Past Extinctions /biointeractive/learning-past-extinctions Lecture Paleobiology, Biodiversity, Human impacts Wednesday, March 18, 2015 - 11:21am

There is still time to avoid a sixth mass extinction.

Humans, Biodiversity, and Habitat Loss /biointeractive/humans-biodiversity-and-habitat-loss Lecture Paleobiology, Populations, Biodiversity, Conservation biology, Human impacts Wednesday, March 18, 2015 - 11:24am

Human activities and their effects on biodiversity in the past, present, and future.

Rescuing Species /biointeractive/rescuing-species Lecture Populations, Biodiversity, Conservation biology, Population genetics, Human impacts Wednesday, March 18, 2015 - 11:28am

How to preserve genetic diversity that is threatened by habitat loss.

Extreme Life of the Sea /biointeractive/extreme-life-sea Lecture Biodiversity, Conservation biology, Animals, Human impacts Wednesday, March 18, 2015 - 11:31am

The threat to biodiversity in the ocean differs from the threats on the land.

Ocean Species Respond to Climate Change /biointeractive/ocean-species-respond-climate-change Lecture Biodiversity, Animals, Gene expression, Climate, Photosynthesis Wednesday, March 18, 2015 - 11:35am

Coral reefs, how they are threatened by climate change, and how to protect them.

Dodging Extinction /biointeractive/dodging-extinction Lecture Paleobiology, Biodiversity, Earth history Wednesday, March 18, 2015 - 11:37am

What steps can be taken to avoid the sixth mass extinction?

Saving Biodiversity Discussion /biointeractive/saving-biodiversity-discussion Lecture Biodiversity, Conservation biology, Human impacts, Science and society Wednesday, March 18, 2015 - 1:15pm

A sixty-minute discussion on biodiversity.

Animated Life: Pangea /biointeractive/animated-life-pangea Animated Short Earth history, History of science Thursday, March 19, 2015 - 2:40pm

The story of Alfred Wegener, who came up with the idea that continents once formed a single landmass and had drifted apart. Also available in Spanish.

Supporting the Ecosystem /biointeractive/supporting-ecosystem Image of the Week Ecosystems, Biodiversity, Animals Monday, March 23, 2015 - 1:32pm

Pikas are small mammals related to rabbits that can only live in cold climates, either at high latitude or high elevations in North America and Asia.

Steve Palumbi & Megan Morikawa Study Coral Reef Damage in American Samoa /biointeractive/steve-palumbi-megan-morikawa-study-coral-reef-damage-in-american-samoa Scientists at Work Biodiversity, Animals, Climate, Human impacts, Scientific methodology Wednesday, March 25, 2015 - 11:38am

Field research on coral bleaching suggests possibilities for saving threatened reefs.

The Tool-Making Animal /biointeractive/tool-making-animal Scientists at Work Paleobiology, Human evolution Wednesday, March 25, 2015 - 12:20pm

Stone tools reveal a critical transition in the lives of our early human ancestors. 

Mesozoic Film with Quiz /biointeractive/mesozoic-film-quiz Interactive Video Paleobiology, Earth history, History of science, Scientific methodology Wednesday, March 25, 2015 - 12:47pm

Embedded quiz modules test students’ understanding as they watch the short film on the asteroid that caused the extinction of the dinosaurs.

The Embryo Puzzle /biointeractive/embryo-puzzle Image of the Week Developmental biology, Scientific methodology Friday, March 27, 2015 - 1:42pm

A new technique tracks thousands of cells in the fruit fly (Drosophila) embryo during development.

Making the Flow /biointeractive/making-flow Image of the Week Developmental biology, Cell structure Monday, April 6, 2015 - 1:59pm

The surface cells of tadpole embryos have cilia that move the water around them.

Synchronized Division /biointeractive/synchronized-division Image of the Week Animals, Developmental biology, Cell growth and division Monday, April 13, 2015 - 10:21pm

The early embryonic cells of the sand dollar are caught in the act of synchronized cell division.

Icefish Film with Quiz /biointeractive/icefish-film-quiz Interactive Video Mechanisms of evolution, DNA, Circulation, History of science Friday, April 17, 2015 - 1:23pm

Embedded quiz modules test students’ understanding as they watch the short film on the icefish—an example of how genes are reused and recycled.

Following Tracks In The Sky /biointeractive/following-tracks-sky Image of the Week Biodiversity, Behavior, Scientific methodology Monday, April 20, 2015 - 4:18pm

The flight patterns of a flock of black vultures are revealed by a novel digital video technique.

Coral Bleaching Activity /biointeractive/coral-bleaching-activity Activity Biodiversity, Climate, Human impacts, Statistics and math Wednesday, April 22, 2015 - 10:31am

This is a classroom activity in which students use authentic data to assess the threat of coral bleaching around the world. It supports the 2014 Holiday Lectures on Science video featuring Dr. Stephen Palumbi.

Working On The Ant Farm /biointeractive/working-ant-farm Image of the Week Biodiversity, Fungi, Animals Monday, April 27, 2015 - 9:42am

Leaf-cutter ants practice fungus agriculture to provide the ant colony with a steady source of food.

Exploring Biomes in Gorongosa National Park /biointeractive/exploring-biomes-gorongosa-national-park Activity Biosphere, Ecosystems, Biodiversity Thursday, April 30, 2015 - 8:31am

Gorongosa National Park in Mozambique is a region with high ecological diversity that encompasses two distinct biomes. This activity introduces students to the concept of biomes in conjunction with the Gorongosa National Park interactive map click and learn

Warthog Love /biointeractive/warthog-love Image of the Week Biodiversity, Conservation biology, Animals, Behavior Monday, May 4, 2015 - 12:40pm

Warthog mothers look after their young in small family groups.

Save Our Sawfish /biointeractive/save-our-sawfish Image of the Week Biodiversity, Conservation biology, Animals, Behavior Monday, May 11, 2015 - 3:19pm

A smalltooth sawfish (Pristis pectinata) patrols the murky waters of the Everglades National Park in Florida.

Mapping a Kidney’s Tubes /biointeractive/mapping-kidney-s-tubes Image of the Week Circulation Monday, May 18, 2015 - 3:15pm

An intricate system of tubes in the kidney filters out waste products from the blood.

The Art of Hiding /biointeractive/art-hiding Image of the Week Mechanisms of evolution, Animals, Behavior Monday, May 25, 2015 - 3:35pm

Animal mimics evolved markings that make them look either like other animals or inanimate objects.

Dottyback in Damselfish Clothing /biointeractive/dottyback-damselfish-clothing Image of the Week Skin, muscles, and bones, Behavior, Cell signaling Monday, June 1, 2015 - 3:20pm

Dottyback fish change color by altering the proportions of yellow and black pigment cells in their skin to mimic Damselfish.

Shades of Pollen /biointeractive/shades-pollen Image of the Week Biodiversity, Animals, Behavior Monday, June 8, 2015 - 11:01am

The variety of colors of cells in a honeycomb comes from pollen collected from different plant species.

Tick Hiker /biointeractive/tick-hiker Image of the Week Animals, Behavior, Infectious disease Monday, June 15, 2015 - 1:50pm

An adult female Blacklegged tick (Ixodes scapularis), commonly known as the deer tick, awaits passing wildlife. 

Solar Fix /biointeractive/solar-fix Image of the Week Plants, Cell structure, Photosynthesis Monday, June 22, 2015 - 12:44pm

The cells of the liverwort (Marchantia polymorpha) are packed with chloroplasts.

Look Who's Coming for Dinner: Selection by Predation /biointeractive/look-whos-coming-dinner-selection-predation Activity Natural selection, Statistics and math Wednesday, June 24, 2015 - 10:42am

This activity supports the film The Origin of Species: Lizards in an Evolutionary Tree. Students are asked to formulate a hypothesis, and collect and analyze real research data to understand how quickly natural selection can act on specific traits in a population. Also available in Spanish.

The Biology of Skin Color /biointeractive/biology-skin-color Short Film Human evolution, DNA, Gene expression, Skin, muscles, and bones Monday, June 29, 2015 - 2:19pm

Penn State University anthropologist Dr. Nina Jablonski walks us through the evidence that the different shades of skin color among human populations arose as adaptations to the intensity of ultraviolet radiation in different parts of the world. Also available in Spanish.

Sand Flea Fireworks /biointeractive/sand-flea-fireworks Image of the Week Biodiversity, Animals Monday, June 29, 2015 - 4:16pm

The front leg of a sand flea stained with colorful dyes.

How We Get Our Skin Color /biointeractive/how-we-get-our-skin-color Animation Gene expression, Gene regulation, Skin, muscles, and bones, Cell structure Tuesday, June 30, 2015 - 12:51pm

This engaging animation shows how human skin cells produce the pigment melanin, which gives skin its color. 

Episode 1: Your Inner Fish /biointeractive/episode-1-your-inner-fish Feature Film Paleobiology, Mechanisms of evolution, Skin, muscles, and bones, Scientific methodology Tuesday, June 30, 2015 - 2:18pm

See how the genetic legacy of a fish can be seen today in our own DNA.

PLEASE N​OTE: Due to international distribution restrictions, these programs can only be streamed in the United States and Canada.

Episode 2: Your Inner Reptile /biointeractive/episode-2-your-inner-reptile Feature Film Paleobiology, Mechanisms of evolution, Skin, muscles, and bones Tuesday, June 30, 2015 - 2:52pm

Join Neil Shubin as he links our hair, teeth and hearing to ancient reptilian ancestors.

PLEASE N​OTE: Due to international distribution restrictions, these programs can only be streamed in the United States and Canada.

Episode 3: Your Inner Monkey /biointeractive/episode-3-your-inner-monkey Feature Film Paleobiology, Human evolution, Mechanisms of evolution, Neuroscience, Skin, muscles, and bones Tuesday, June 30, 2015 - 2:58pm

Join Neil Shubin as he links our hands, vision, and brains to ancient primate ancestors.

PLEASE N​OTE: Due to international distribution restrictions, these programs can only be streamed in the United States and Canada.

Film Guide: Your Inner Fish /biointeractive/film-guide-your-inner-fish Film Guide Mechanisms of evolution, Paleobiology, Human evolution Thursday, July 2, 2015 - 3:56pm

This guide complements the three-part television series Your Inner Fish. This series describes the legacy of our ancient animal ancestors and the evidence of their relationship to us.

Beak of the Finch Film With Quiz /biointeractive/beak-finch-film-quiz Interactive Video Natural selection, Animals Monday, July 13, 2015 - 8:28pm

Embedded quiz modules test students’ understanding as they watch a short film on the evolution of the finch species found on the Galápagos Islands.

BioInteractive Alignment to Vision & Change Concepts and Practices /biointeractive/biointeractive-alignment-vision-change-concepts-and-practices Teacher Guide Tuesday, July 21, 2015 - 11:37am

This guide correlates resources available on BioInteractive.org with the Core Concepts and Disciplinary Practices of the 2011 report: Vision and Change in Undergraduate Biology

The Origin of Birds Film Guide /biointeractive/origin-birds-film-guide Film Guide Evolutionary theory, Paleobiology, History of science Friday, July 24, 2015 - 2:55pm

The following classroom-ready resources complement Great Transitions: The Origin of Birds. Featuring vertebrate paleontologist Dr. Julia Clarke, the film walks us through the evidence that birds are a lineage of theropod dinosaurs. 

Living Dinosaurs: Fact or Fiction? /biointeractive/living-dinosaurs-fact-or-fiction Activity Evolutionary theory, Paleobiology, History of science Friday, July 24, 2015 - 3:28pm

Students evaluate and discuss statements about the evolutionary relationship between birds and dinosaurs and other facts about these groups, before and after watching the short film Great Transitions: The Origin of Birds. Also available in Spanish.

WildCam Gorongosa /biointeractive/wildcam-gorongosa Click & Learn Conservation biology, Communities, Populations, Biodiversity, Animals, Behavior, Scientific methodology Tuesday, September 8, 2015 - 1:02pm

Researchers in Gorongosa National Park use remote trail cameras to study the park’s wildlife. You can contribute to this important research through WildCam Gorongosa, an online citizen science platform.

Tracking Lion Recovery in Gorongosa National Park /biointeractive/tracking-lion-recovery-in-gorongosa-national-park Scientists at Work Conservation biology, Human impacts, Scientific methodology Tuesday, August 4, 2015 - 3:08pm

See how scientists in Gorongosa National Park are using GPS satellite collars and motion-sensitive cameras to gather data about the recovery of the park’s lion population.

Creating Chains and Webs to Model Ecological Relationships /biointeractive/creating-chains-and-webs-model-ecological-relationships Activity Conservation biology, Ecosystems, Biodiversity, Animals Friday, August 14, 2015 - 2:14pm

Students use cards to build model food webs and evaluate how ecological disturbances affect each trophic level. Also available in Spanish.

School's Back! /biointeractive/schools-back Image of the Week Animals, Behavior, Scientific methodology Monday, August 17, 2015 - 10:38am

Golden shiner fish (Notemigonus crysoleucas) stay in school for the shade.

How Did Dinosaurs Regulate Their Body Temperature? /biointeractive/how-did-dinosaurs-regulate-their-body-temperature Activity Evolutionary theory, Organismal Biology, Statistics and math Tuesday, August 18, 2015 - 12:48pm

This activity uses data from a 2014 scientific paper to explore thermoregulation in living and extinct animals, including dinosaurs. 

Lactase Persistence: Evidence for Selection /biointeractive/lactase-persistence-evidence-selection Activity Human evolution, Gene expression, Scientific methodology Wednesday, August 19, 2015 - 1:11pm

This activity provides a case study in human evolution that connects genotype, phenotype, culture, and graphical analysis skills. Also available in Spanish.

Surveying Gorongosa's Biodiversity /biointeractive/surveying-gorongosas-biodiversity Scientists at Work Conservation biology, Human impacts, Scientific methodology Wednesday, August 19, 2015 - 2:19pm

Biologists Piotr Naskrecki and Jennifer Guyton identify and record the diversity of species in Gorongosa National Park’s Cheringoma Plateau.

Fungus-Cultivating Termites of the African Savanna — Ecosystem Engineers /biointeractive/fungus-cultivating-termites-african-savanna-ecosystem-engineers Poster Ecosystems, Animals, Statistics and math Wednesday, August 19, 2015 - 2:55pm

The poster for the 2015 Holiday Lectures on Science, Patterns and Processes in Ecology, illustrates how termites enhance the productivity and stability of African savanna ecosystems.

Schooling Behavior of Stickleback Fish from Different Habitats /biointeractive/schooling-behavior-stickleback-fish-different-habitats Data Point Evolution of populations, Behavior, Statistics and math, Scientific methodology Saturday, August 22, 2015 - 8:25pm

A team of scientists studied the schooling behavior of threespine stickleback fish by experimentally testing how individual fish responded to an artificial fish school model.

What Makes Flowers Red? /biointeractive/what-makes-flowers-red Image of the Week Biochemistry, Plants, Cell structure Monday, August 31, 2015 - 10:34pm

The petals of flowers get their vibrant colors from cells packed with pigments such as orange carotenoids and pink anthocyanins.

Cracking the Hardest Nut /biointeractive/cracking-hardest-nut Image of the Week Speciation, Animals Monday, September 7, 2015 - 3:29pm

The Large Ground-Finch (Geospiza magnirostris) has the largest beak of all Darwin’s finches on the Galápagos Islands.

Effects of Natural Selection on Finch Beak Size /biointeractive/effects-of-natural-selection-on-finch-beak-size Data Point Mechanisms of evolution, Natural selection, Evolution of populations, Statistics and math, Scientific methodology Sunday, September 13, 2015 - 3:04pm

Rosemary and Peter Grant studied the change in beak depths of finches on the island of Daphne Major in the Galápagos Islands after a drought.

Spreadsheet Tutorial 1 -- Formulae, Functions, and Averages /biointeractive/spreadsheet-tutorial-1-formulae-functions-and-averages Activity Speciation, Statistics and math, Scientific methodology Tuesday, September 15, 2015 - 4:03pm

Use formulas and functions to calculate the mean and median.

Spreadsheet Tutorial 2 -- Autofill Data, Cell References, and Standard Deviation /biointeractive/spreadsheet-tutorial-2-autofill-data-cell-references-and-standard-deviation Activity Speciation, Scientific methodology, Statistics and math Tuesday, September 15, 2015 - 4:06pm

Generate a table with autofill, and use absolute cell reference to calculate variance and standard deviation.

Spreadsheet Tutorial 3 -- Column Graphs, Error Bars, and Standard Error of the Mean /biointeractive/spreadsheet-tutorial-3-column-graphs-error-bars-and-standard-error-mean Activity Speciation, Scientific methodology, Statistics and math Tuesday, September 15, 2015 - 4:09pm

Generate a column or bar graph with standard error bars.

Film Guide for The Biology of Skin Color /biointeractive/film-guide-for-the-biology-of-skin-color Film Guide Human evolution, DNA, Gene expression, Skin, muscles, and bones Monday, September 21, 2015 - 9:41am

The following classroom-ready resources complement The Biology of Skin Color. Featuring anthropologist Dr. Nina Jablonski, the film walks us through the evidence that differences in human skin color are adaptations to varying intensity of UV light. Also available in Spanish.

You Lookin' at Me? /biointeractive/you-lookin-me Image of the Week Communities, Populations, Biodiversity, Animals Monday, September 21, 2015 - 3:35pm

Waterbucks caught in the act as they eat their way in front of a trail camera in Mozambique, Africa.

iTunes U Course: Gorongosa: Using Citizen Science to Study Ecology /biointeractive/itunes-u-course-gorongosa-using-citizen-science-study-ecology Click & Learn Ecosystems, Communities, Biodiversity, Conservation biology, Animals, Scientific methodology Monday, September 21, 2015 - 9:33pm

This iTunes U course teaches concepts in ecology and scientific inquiry through a citizen science project in Gorongosa National Park, Mozambique.

Human Feet Are Strange /biointeractive/human-feet-are-strange Activity Paleobiology, Human evolution, Scientific methodology Friday, September 25, 2015 - 10:15am

In this hands-on activity students examine the evidence for the evolution of human bipedality as revealed by a trail of fossil footprints. Also available in Spanish.

Wait for Me! /biointeractive/wait-me Image of the Week Communities, Biodiversity, Animals, Behavior Monday, September 28, 2015 - 1:22pm

A remote trail camera captures a photo of an elephant calf trying to catch up to the rest of its family group in Gorongosa National Park.

Mass Extinction: Life at the Brink /biointeractive/mass-extinction-life-brink Feature Film Paleobiology, Earth history, Human impacts, Scientific methodology Wednesday, September 30, 2015 - 10:40am

Five times in Earth’s past, the vast majority of plant and animal species have been annihilated in a geologic instant. What triggered these dramatic events, and what might they tell us about the fate of our world?

Helena With Cub /biointeractive/helena-cub Image of the Week Communities, Populations, Biodiversity, Animals Monday, October 5, 2015 - 4:12pm

A lioness relaxing with her cub in Gorongosa National Park, where scientists are studying the recovery of the lion population. 

Mozambique Mounds /biointeractive/mozambique-mounds Image of the Week Evolution of populations, Ecosystems, Animals, Behavior Monday, October 12, 2015 - 2:19pm

Termite mounds in central Mozambique appear as regularly spaced islands of dark-green vegetation in a sea of grassland. 

How We Get Our Skin Color Interactive /biointeractive/how-we-get-our-skin-color-interactive Interactive Video Human evolution, Biochemistry, Skin, muscles, and bones, Nutrition, Cell structure, Cancer Tuesday, October 13, 2015 - 11:43am

This interactive animation about the biology of skin color provides stop points at which students can further explore the material through additional text and illustrations, videos, questions, and simple interactive widgets.

Modeling Ecosystem Effects of Termite Mound Patterns /biointeractive/modeling-ecosystem-effects-of-termite-mound-patterns Data Point Ecosystems, Plants, Climate, Statistics and math, Scientific methodology Monday, October 19, 2015 - 3:03pm

Dr. Corina Tarnita and colleagues studied how a pattern of termite mounds across a dryland ecosystem enhances resilience against desertification.

Film Guide for Popped Secret: The Mysterious Origin of Corn /biointeractive/film-guide-for-popped-secret-the-mysterious-origin-of-corn Film Guide Paleobiology, Artificial selection, Plants, Mendelian inheritance, Gene regulation, Scientific methodology Wednesday, October 21, 2015 - 10:24am

The following classroom-ready resources complement the film Popped Secret: The Mysterious Origin of Corn, which tells the story of how geneticists and archaeologists have come together to determine how and where corn was domesticated nearly 9,000 years ago. Also available in Spanish.

Patterns and Processes in Ecology /biointeractive/patterns-and-processes-ecology Lecture Ecosystems, Populations, Biodiversity, Statistics and math Thursday, October 22, 2015 - 2:51pm

What controls the numbers and distributions of animals in their environment? How do animals interact with other species? How do natural patterns arise in nature? Find out in the 2015 Holiday Lectures on Science.

Africa's Savanna Ecosystems /biointeractive/africas-savanna-ecosystems Lecture Biosphere, Ecosystems, Climate Thursday, October 22, 2015 - 3:06pm

Savannas cover 20 percent of Earth’s surface and much of Africa. The patterns and processes that occur in this globally important biome illustrate core concepts in ecology.

Patterns in Nature /biointeractive/patterns-nature Lecture Ecosystems, Plants, Statistics and math Thursday, October 22, 2015 - 3:17pm

Regular spatial patterns abound in natural systems. Understanding how patterns arise in ecosystems provides insights into how these ecosystems function.

How Species Coexist /biointeractive/how-species-coexist Lecture Ecosystems, Biodiversity, Bioinformatics, Scientific methodology Thursday, October 22, 2015 - 3:21pm

Large herbivores in the African savanna coexist by partitioning ecological niches by time, space, and diet.

Modeling Populations and Species Interactions /biointeractive/modeling-populations-and-species-interactions Lecture Communities, Populations, Conservation biology, Statistics and math Thursday, October 22, 2015 - 3:23pm

Gorongosa National Park in Mozambique provides several examples for how to model the growth of animal populations and then check the models against actual data. 

Communities as Ecological Networks /biointeractive/communities-ecological-networks Lecture Ecosystems, Communities, Scientific methodology, Statistics and math Thursday, October 22, 2015 - 3:59pm

Ecosystems include complex interactions between animals and plants, which can be measured experimentally and investigated using mathematical models.

Conserving and Restoring Ecosystems /biointeractive/conserving-and-restoring-ecosystems Lecture Ecosystems, Biodiversity, Conservation biology, Science and society Thursday, October 22, 2015 - 4:02pm

Two important questions in ecology are "How do we conserve ecosystems?" and  "When we try to restore damaged ecosystems, what state do we restore them to?"

The Science of Camera Traps /biointeractive/science-camera-traps Lecture Communities, Biodiversity, Conservation biology, Scientific methodology Thursday, October 22, 2015 - 5:03pm

A discussion of camera traps and their use in ecological research.

Primate in a Pumpkin /biointeractive/primate-pumpkin Image of the Week Speciation, Biodiversity, Conservation biology Tuesday, October 27, 2015 - 9:02am

The Aye-Aye is a nocturnal lemur, a member of a group of primates that live only on the island of Madagascar. 

Reckless Growth /biointeractive/reckless-growth Image of the Week Genetic basis of disease, Developmental biology, Cancer Monday, November 2, 2015 - 4:09pm

The organization of cells in a healthy mouse intestine is lost in a growing tumor.

Natural Selection and the Evolution of Darwin's Finches /biointeractive/natural-selection-and-evolution-darwins-finches Activity Mechanisms of evolution, Natural selection, Evolution of populations, Scientific methodology Wednesday, November 4, 2015 - 8:58am

This lesson is aligned with the NGSS science practices of engaging in argument from evidence using mathematical and computational thinking and analyzing and interpreting data.

The Origin of Flight: What Use Is Half a Wing? /biointeractive/the-origin-of-flight-what-use-is-half-a-wing Scientists at Work Paleobiology, Mechanisms of evolution, Skin, muscles, and bones, Scientific methodology Monday, November 9, 2015 - 8:54am

Biologist Ken Dial's study of how young birds use their developing wings sheds light on the evolution of flight in birds.

Human Skin Color: Evidence for Selection /biointeractive/human-skin-color-evidence-for-selection Activity Human evolution, Natural selection, Evolution of populations, Skin, muscles, and bones, Scientific methodology Monday, November 9, 2015 - 9:28am

This case study is based on the short film The Biology of Skin Color. Students use real data to propose hypotheses, make predictions, and justify claims with evidence. Also available in Spanish.

Coloring the Past /biointeractive/coloring-past Image of the Week Paleobiology, Biochemistry, Cell structure Monday, November 9, 2015 - 1:46pm

An electron micrograph of tightly-packed melanosomes in a 55.4-million-year-old fossil bird feather unearthed in Denmark.

Gorongosa: Making Observations Activity /biointeractive/gorongosa-making-observations-activity Activity Ecosystems, Communities, Biodiversity, Animals, Scientific methodology Monday, November 9, 2015 - 2:02pm

In this activity, students will use trail camera photos from WildCam Gorongosa to make observations and ask scientific questions as part of the scientific process.

Comparative Anatomy of the Domestic Chicken /biointeractive/comparative-anatomy-domestic-chicken Click & Learn Evolutionary theory, Paleobiology, Phylogeny and classification, Skin, muscles, and bones, Scientific methodology Tuesday, November 10, 2015 - 12:57pm

Trace the evolutionary history of birds by comparing the shapes and structures of certain bones in a chicken to those of some of its extinct and living relatives. Also available in Spanish.

Analyzing Patterns in the Savanna Landscape /biointeractive/analyzing-patterns-in-the-savanna-landscape Scientists at Work Ecosystems, Statistics and math, Scientific methodology Wednesday, November 11, 2015 - 2:47pm

Mathematician-turned biologist Dr. Corina Tarnita describes the importance of termite mounds in a savanna ecosystem. Also available in Spanish.

Niche Partitioning and Species Coexistence /biointeractive/niche-partitioning-and-species-coexistence Scientists at Work Ecosystems, Biodiversity, Scientific methodology Wednesday, November 11, 2015 - 2:52pm

Professor Robert Pringle describes the cutting-edge method of DNA metabarcoding used to reveal how similar animals share resources. Film and worksheet also available in Spanish.

Genetic Origin of Variation in Human Skin Color /biointeractive/genetic-origin-of-variation-in-human-skin-color Data Point Gene expression, Skin, muscles, and bones, Statistics and math, Scientific methodology Monday, November 16, 2015 - 2:49pm

Dr. Rebecca Lamason and colleagues studied the genetic origin of variation in human skin color using a model organism, the zebrafish.

Sampling and Normal Distribution /biointeractive/sampling-and-normal-distribution Click & Learn Statistics and math Friday, November 20, 2015 - 8:07am

Graphically explore how sample distribution and standard error of the mean depends on the sample size.

To Brine, Or Not To Brine? /biointeractive/brine-or-not-brine Image of the Week Proteins, Nutrition, Cell structure Monday, November 23, 2015 - 2:07pm

Soaking your Thanksgiving turkey in a salt solution (brine) alters the arrangement of muscle fiber protein molecules.

What Is Fat? /biointeractive/what-fat Poster Lipids, Nutrition, Cell structure, Cell signaling Friday, September 24, 2004 - 12:11pm

The poster from the 2004 Holiday Lectures on Science, The Science of Fat. See how fat is stored and metabolized.
(This poster is designed to printed at a maximum size of 29.5" x 23.5".)

A Predator in the Plankton /biointeractive/predator-plankton Image of the Week Ecosystems, Biodiversity, Protists, Cell structure Monday, November 30, 2015 - 3:22pm

The comb jelly (Beroe cucumis) uses its large mouth and cilia-powered motor to prey upon members of the plankton family, including other ctenophores.

Coral Fluorescence /biointeractive/coral-fluorescence Image of the Week Ecosystems, Biodiversity, Photosynthesis Monday, December 7, 2015 - 3:12pm

Most corals contain proteins that emit light, or fluoresce, when light shines on them.

Gorongosa's Water Cycle /biointeractive/gorongosas-water-cycle Animation Biosphere, Climate Tuesday, December 8, 2015 - 9:01am

This animation illustrates the main stages of the water cycle in the setting of Gorongosa National Park.

Lesson 1 - WildCam Gorongosa /biointeractive/lesson-1-wildcam-gorongosa Activity Ecosystems, Communities, Biodiversity, Conservation biology, Animals Friday, December 11, 2015 - 1:53pm

In this lesson students will learn how to use WildCam Gorongosa and get introduced to some of the animals in the park.

Lesson 2 - Gorongosa National Park /biointeractive/lesson-2-gorongosa-national-park Activity Ecosystems, Communities, Biodiversity, Conservation biology, Animals Friday, December 11, 2015 - 2:07pm

In this lesson students will learn about the history of Gorongosa National Park and the ongoing restoration effort through readings and videos.

Lesson 3 - Scientific Inquiry with WildCam Gorongosa /biointeractive/lesson-3-scientific-inquiry-wildcam-gorongosa Activity Ecosystems, Communities, Biodiversity, Animals, Scientific methodology Friday, December 11, 2015 - 2:11pm

In this lesson, students will use WildCam Gorongosa to start making observations and generating scientific questions using a single trail camera photo.

Lesson 4 - Gorongosa's Food Webs /biointeractive/lesson-4-gorongosas-food-webs Activity Ecosystems, Communities, Biodiversity, Conservation biology, Animals Friday, December 11, 2015 - 2:19pm

In this lesson, students will learn about how food webs are constructed and trophic levels in an ecological community. They will then use animals that they identify in WildCam Gorongosa to construct food chains and food webs, and study the impacts of disturbances.

Lesson 5 - Tracking Lion Communities /biointeractive/lesson-5-tracking-lion-communities Activity Communities, Conservation biology, Animals, Human impacts, Scientific methodology Friday, December 11, 2015 - 2:23pm

For this lesson, students will watch the video “Tracking Lion Recovery in Gorongosa National Park” and complete a worksheet.

Lesson 6 - Biomes and Landscapes /biointeractive/lesson-6-biomes-and-landscapes Activity Biosphere, Ecosystems, Biodiversity, Plants Friday, December 11, 2015 - 2:29pm

In this lesson, students will use an interactive map of Gorongosa National Park to learn about biomes. They will then explore E.O. Wilson’s Life on Earth iBook to learn about the varied landscapes and vegetation types in Gorongosa.

Lesson 7 - Observations Across Habitats /biointeractive/lesson-7-observations-across-habitats Activity Ecosystems, Communities, Biodiversity, Animals, Scientific methodology Friday, December 11, 2015 - 2:33pm

In this lesson, students will compare wildlife in two different habitats by making observations using sets of trail camera photos. They will then use these observations to formulate questions for further study.

Lesson 8 - WildCam Gorongosa: Data Analysis /biointeractive/lesson-8-wildcam-gorongosa-data-analysis Activity Ecosystems, Communities, Biodiversity, Animals, Scientific methodology, Statistics and math Friday, December 11, 2015 - 2:39pm

In this activity, students will collect actual data from WildCam Gorongosa and use those data to create graphs and answer an ecological question of their choice.

Resistance to Coral Bleaching /biointeractive/resistance-to-coral-bleaching Data Point Ecosystems, Climate, Statistics and math, Scientific methodology Monday, December 14, 2015 - 5:45pm

To test whether corals can become more resistant to bleaching, Dr. Steve Palumbi and colleagues performed a series of experiments in the U.S. National Park of American Samoa off of Ofu Island.

Twinkle, Twinkle Little Desmid /biointeractive/twinkle-twinkle-little-desmid Image of the Week Ecosystems, Plants, Photosynthesis Monday, December 21, 2015 - 3:19pm

These tiny star-shaped organisms are single-celled, freshwater green algae called desmids.

New Year Bash /biointeractive/new-year-bash Image of the Week Mechanisms of evolution, Biodiversity, Skin, muscles, and bones Monday, December 21, 2015 - 3:37pm

Some mantis shrimps, for example, Odontodactylus sp., can smash open prey, such as snails and crabs, using powerful specialized limbs.

Gorongosa: Scientific Inquiry and Data Analysis /biointeractive/gorongosa-scientific-inquiry-and-data-analysis Activity Ecosystems, Communities, Biodiversity, Animals, Scientific methodology Tuesday, December 22, 2015 - 1:50pm

In this activity, students will be guided through the investigation of a scientific question, using data from ongoing research in Gorongosa National Park.

Trends in Atmospheric Carbon Dioxide /biointeractive/trends-in-atmospheric-carbon-dioxide Data Point Climate, Human impacts, Statistics and math, Scientific methodology Monday, January 4, 2016 - 12:43pm

Charles David Keeling began measuring atmospheric carbon dioxide (CO2) in 1958 at the Mauna Loa observatory on the big island of Hawaii.  This graph shows atmospheric carbon dioxide concentration in parts per million (ppm) by volume from 1958 to 2016. Worksheet also available in Spanish.

Popped Secret Film with Quiz /biointeractive/popped-secret-film-quiz Interactive Video Artificial selection, Paleobiology, Plants, Gene regulation Tuesday, January 5, 2016 - 9:08am

Embedded quiz modules test students’ understanding as they watch a short film on the evolutionary origins of corn.

Bioinspired by Seahorse Tails /biointeractive/bioinspired-seahorse-tails Image of the Week Animals, Skin, muscles, and bones, Scientific methodology Monday, January 11, 2016 - 11:23am

The flexibility of the seahorse’s armored tail is inspiring novel designs with biomedical and architectural applications.

Mass Extinctions Interactive /biointeractive/mass-extinctions-interactive Click & Learn Paleobiology, Biodiversity, Earth history Wednesday, January 13, 2016 - 11:50am

Discover the environmental factors that caused the five big mass extinctions in Earth’s history and which species they impacted.

Crystals and the Color of Skin /biointeractive/crystals-and-color-skin Image of the Week Biodiversity, Skin, muscles, and bones, Cell structure Monday, January 18, 2016 - 10:48am

The panther chameleon alters the arrangement of tiny crystals in its skin to change color.

Origin of Birds With Quiz /biointeractive/origin-birds-quiz Interactive Video Mechanisms of evolution, Paleobiology, Skin, muscles, and bones, Scientific methodology Thursday, January 21, 2016 - 7:35am

Embedded quiz modules test students’ understanding as they watch a short film about the evidence that showed birds descended from dinosaurs.

Cancer Evolution /biointeractive/cancer-evolution Image of the Week Genetic basis of disease, Cell growth and division, Cancer Monday, January 25, 2016 - 8:22pm

A computer simulation of cancer growth, in which cell colors correspond to different mutations, reveals that a tumor mass is a mixture of genetically similar cells.

Animated Life: Mary Leakey /biointeractive/animated-life-mary-leakey Animated Short Paleobiology, Human evolution, History of science Thursday, January 28, 2016 - 12:17pm

This animated short film recounts the life and work of paleoanthropologist Mary Leakey, including her discovery of the Laetoli footprints.

Animated Life: The Living Fossil Fish /biointeractive/animated-life-living-fossil-fish Animated Short Evolutionary theory, Evolution of populations, Biodiversity, Earth history, History of science Thursday, January 28, 2016 - 12:22pm

This animated short film tells the engaging tale of the discovery of the coelacanth.

Efficacy of a Treatment for Chronic Myeloid Leukemia /biointeractive/efficacy-of-a-treatment-for-chronic-myeloid-leukemia Data Point Proteins, Cancer, Statistics and math, Scientific methodology Monday, February 1, 2016 - 2:19pm

Dr. Brian Druker and colleagues monitored white blood cell counts in six patients with chronic myeloid leukemia treated with the drug, STI571, which blocks the activity of the cancer-causing tyrosine kinase BCR-ABL.

Termite Activity Enhances Ecosystem Productivity and Stability /biointeractive/termite-activity-enhances-ecosystem-productivity-and-stability Animation Ecosystems, Animals Wednesday, February 3, 2016 - 5:38pm

Termite activity increases soil moisture and nutrient accumulation, strengthening African savanna ecosystems.

The Heart of the Matter /biointeractive/heart-matter Image of the Week Circulation, Developmental biology, History of science Monday, February 8, 2016 - 12:55pm

Early theories of the heart’s role were largely based on its central position in the body.

Social Networking /biointeractive/social-networking Image of the Week Neuroscience, Behavior, Cell structure Monday, February 15, 2016 - 5:02pm

The arrangement of nerve cells in the region of the brain called the hippocampus is essential for the formation and storage of new memories.

Origin of Humans with Quiz /biointeractive/origin-humans-quiz Interactive Video Mechanisms of evolution, Paleobiology, Human evolution, Skin, muscles, and bones Tuesday, February 16, 2016 - 9:37am

Embedded quiz modules test students’ understanding as they watch a short film on the major human fossil finds from Africa  and what they reveal about the history of our evolutionary origins.

Surveying Ant Diversity in Gorongosa National Park /biointeractive/surveying-ant-diversity-gorongosa-national-park Scientists at Work Conservation biology, Ecosystems, Biodiversity, Scientific methodology Friday, February 19, 2016 - 1:56pm

Conservation biologist Leeanne Alonso is surveying ant species Gorongosa National Park to monitor the health of the park’s ecosystems

A Science-Based Approach to Restoring Gorongosa's Wildlife /biointeractive/a-science-based-approach-to-restoring-gorongosas-wildlife Scientists at Work Conservation biology, Ecosystems, Biodiversity, Scientific methodology Friday, February 19, 2016 - 2:02pm

Scientists from Gorongosa National Park relocate zebras from a nearby reserve as part of the effort to restore healthy wildlife populations.

Slug Power /biointeractive/slug-power Phenomenal Image Mechanisms of evolution, Biodiversity, Nutrition, Photosynthesis Monday, February 22, 2016 - 3:23pm

Students explore photos of a sea slug and chloroplasts as anchoring phenomena to explore photosynthesis concepts.

Effects of Predation on the Niche of Lizards /biointeractive/effects-of-predation-on-the-niche-of-lizards Data Point Communities, Animals, Statistics and math, Scientific methodology Monday, February 29, 2016 - 10:52am

A team of scientists studied the effects of introducing a lizard predator on the food webs of a group of small islands in the Bahamas.

Skin Color Interactive Video /biointeractive/skin-color-interactive-video Interactive Video Human evolution, DNA, Gene expression, Skin, muscles, and bones Monday, March 7, 2016 - 10:00am

Embedded quiz modules test students’ understanding as they watch a short film that explores the evidence for the evolution of the variation in skin color among human populations.

The Teosinte Hypothesis /biointeractive/teosinte-hypothesis Activity Artificial selection, Plants, Mendelian inheritance, Statistics and math, Scientific methodology Monday, March 7, 2016 - 2:43pm

In this lesson, students work through the mathematics and concepts behind George Beadle’s claim that teosinte is the wild ancestor of maize. Also available in Spanish.

Student Discussion on Patterns and Processes in Ecology /biointeractive/student-discussion-patterns-and-processes-ecology Lecture Ecosystems, Conservation biology, Scientific methodology Monday, March 7, 2016 - 3:18pm

The 2015 Holiday Lecture discussion session.

Cheese Pi /biointeractive/cheese-pi Image of the Week Ecosystems, Bacteria, Fungi Monday, March 7, 2016 - 3:41pm

Colonies of bacteria from the rind of a cave-aged cheese, cultured on a petri dish.

The Shy Shark's Secret /biointeractive/shy-sharks-secret Image of the Week Biodiversity, Chemistry, Animals Monday, March 14, 2016 - 3:15pm

The Chain catshark (Scyliorhinus retifer) fluoresces bright green when illuminated in blue light.

Measuring Biodiversity in Gorongosa /biointeractive/measuring-biodiversity-gorongosa Activity Ecosystems, Communities, Biodiversity, Animals, Statistics and math Monday, March 14, 2016 - 3:28pm

In this activity, students will calculate species richness, evenness, and the Shannon diversity index for various habitat types using data from trail cameras in Gorongosa National Park.

Building Ecological Pyramids /biointeractive/building-ecological-pyramids Activity Ecosystems, Communities, Animals, Statistics and math Monday, March 14, 2016 - 3:31pm

In this activity, students will build biomass pyramids depicting trophic levels of various habitat types using data from trail cameras in Gorongosa National Park.

Scientific Inquiry Using WildCam Gorongosa /biointeractive/scientific-inquiry-using-wildcam-gorongosa Activity Ecosystems, Communities, Biodiversity, Animals, Scientific methodology Monday, March 14, 2016 - 3:37pm

In this activity, students will be guided through the investigation of a scientific question, using data from trail cameras in Gorongosa National Park.

Bird's Eye View /biointeractive/birds-eye-view Image of the Week Speciation, Biochemistry, Neuroscience Wednesday, March 16, 2016 - 12:16pm

Unlike the human retina, in which red and green cones are randomly distributed, the five cone types of the bird’s retina are arranged in a highly regular mosaic.

Identifying Autism Genes by Tracking Gene Mutations /biointeractive/identifying-autism-genes-by-tracking-gene-mutations Data Point Genomics, Genetic basis of disease, Statistics and math, Scientific methodology Friday, March 25, 2016 - 10:01am

A team of scientists used homozygosity mapping to map SNPs on chromosome 3 in a family with an autistic son to identify a likely gene that caused the disorder.

Trojan Micro Horses /biointeractive/trojan-micro-horses Image of the Week Biochemistry, Immunology, Cell signaling, Stem cells Monday, March 28, 2016 - 9:05am

Spheres made from sugar polymers hide insulin-producing cells from attack by the immune system.

Lactase Film with Quiz /biointeractive/lactase-film-quiz Interactive Video Human evolution, Gene expression, Gene regulation, Nutrition Monday, March 28, 2016 - 9:33am

Embedded quiz modules test students’ understanding as they watch a short film that explores the evolution of the ability to digest lactose as adults (lactose tolerance) and the genetic changes associated with the trait.

Ocean Acidification /biointeractive/ocean-acidification Activity Chemistry, Earth processes, Climate, Human impacts Monday, March 28, 2016 - 12:38pm

In this hands-on activity, students simulate the effects of decreasing pH caused by rising levels of atmospheric carbon dioxide.

Spreadsheet Tutorial 4: t-Test /biointeractive/spreadsheet-tutorial-4-t-test Activity Speciation, Scientific methodology, Statistics and math Tuesday, March 29, 2016 - 10:15pm

Calculate t-values and perform t-tests using built-in functions.

Spreadsheet Tutorial 5: Histogram /biointeractive/spreadsheet-tutorial-5-histogram Activity Speciation, Scientific methodology, Statistics and math Tuesday, March 29, 2016 - 10:22pm

Generate a histogram using a variety of methods.

Some Animals Are More Equal than Others: Keystone Species and Trophic Cascades /biointeractive/some-animals-are-more-equal-others-keystone-species-and-trophic-cascades Short Film Ecosystems, Communities, Populations, History of science, Scientific methodology Friday, April 1, 2016 - 5:53pm

Keystone species and trophic cascades are fundamental concepts in ecology. This short film tells the story of how these concepts were first established through the pioneering experiments of two young researchers: Robert Paine and James Estes.

Counting Glomeruli /biointeractive/counting-glomeruli Image of the Week Circulation, Cell structure, Scientific methodology Monday, April 11, 2016 - 9:52am

The human kidney contains about 1 million tiny filters called glomeruli with associated nephron tubules.

Stickleback Film with Quiz /biointeractive/stickleback-film-quiz Interactive Video Mechanisms of evolution, Gene expression, Gene regulation Tuesday, April 12, 2016 - 11:22am

Embedded quiz modules test students’ understanding as they watch a short film that explains how stickleback fish let scientists study evolution in action, identify key genes, and peer deep into the evolutionary past.

Plaque Attack /biointeractive/plaque-attack Image of the Week Genetic basis of disease, Neuroscience, Cell structure, History of science Sunday, April 17, 2016 - 11:28pm

An amyloid plaque (in purple) is surrounded by branches of damaged neurons (multiple colors) in the brain of a mouse with Alzheimer’s disease.

To Boldly Go /biointeractive/boldly-go Image of the Week Biosphere, Conservation biology, Climate Monday, April 25, 2016 - 1:04pm

A green sea turtle hatchling makes a break for the South Atlantic Ocean from the beach on Ascension Island at sunset.

WildCam Lab /biointeractive/wildcam-lab Click & Learn Communities, Populations, Biodiversity, Animals, Behavior, Scientific methodology Tuesday, April 26, 2016 - 1:39pm

The WildCam Lab is a part of WildCam Gorongosa, an online citizen science platform where users identify animals in trail camera photos. Using the WildCam Lab, students can investigate ecological questions and test hypotheses by exploring trail camera data using an interactive map. 

Unconditional Love /biointeractive/unconditional-love Image of the Week Developmental biology, Neuroscience, Cell growth and division Monday, May 2, 2016 - 3:01pm

A mother and her baby viewed using magnetic resonance imaging (MRI).

Amylase Copy Number and Diet /biointeractive/amylase-copy-number-and-diet Data Point Evolution of populations, Nutrition, Statistics and math, Scientific methodology Monday, May 9, 2016 - 10:25am

A team of scientists investigated whether there is a correlation between the number of AMY1 gene copies and the type of diet (high-starch or low-starch) of a population.

Moth Mimicry: Using Ultrasound to Avoid Bats /biointeractive/moth-mimicry-using-ultrasound-to-avoid-bats Scientists at Work Mechanisms of evolution, Natural selection, Biodiversity, Scientific methodology Tuesday, May 10, 2016 - 6:26am

This video follows scientists as they uncover the ways in which moth species in Gorongosa National Park use ultrasound to avoid being eaten by bats.

Niche Partitioning /biointeractive/niche-partitioning Clip Ecosystems Sunday, May 15, 2016 - 1:14pm

Dr. Rob Pringle introduces the concept of niche partitioning with examples drawn from the African savanna.

Metabarcoding /biointeractive/metabarcoding Clip Ecosystems, Biotechnology Sunday, May 15, 2016 - 6:48pm

Dr. Rob Pringle introduces a new method of studying herbivore diets by extracting plant DNA from animal dung.

Niche Partitioning Activity /biointeractive/niche-partitioning-activity Activity Communities, Populations, Biodiversity, Animals Sunday, May 15, 2016 - 7:03pm

Students are introduced to real-world examples of niche partitioning and cutting-edge technology used to give unprecedented insights into the feeding habits of wild animals.

Colorizing Skin Cells /biointeractive/colorizing-skin-cells Image of the Week Skin, muscles, and bones, Developmental biology, Cell growth and division Monday, May 16, 2016 - 8:21am

The “skinbow” zebrafish has color-coded skin cells when viewed in a microscope using UV light illumination.

Written in Chalk /biointeractive/written-chalk Image of the Week Mechanisms of evolution, Chemistry, Geology, History of science Monday, May 23, 2016 - 1:56pm

The world’s chalk deposits are made of fossilized remains of the shells of tiny microscopic algae.

Origin of a Gene Mutation Causing Early-Onset Alzheimer’s Disease /biointeractive/origin-of-a-gene-mutation-causing-early-onset-alzheimers-disease Data Point Evolution of populations, Genetic basis of disease, Neuroscience, Statistics and math, Scientific methodology Friday, May 27, 2016 - 2:07pm

A team of scientists built a pedigree of a large extended family in Antioquia, Colombia, that has a high prevalence of early-onset familial Alzheimer’s disease due to a mutation in the PSEN1 gene. Worksheets also available in Spanish.

Jurassic Mammal Teeth /biointeractive/jurassic-mammal-teeth Image of the Week Paleobiology, Phylogeny and classification, Scientific methodology Monday, June 6, 2016 - 11:19am

A three-dimensional model of a fossilized jaw from a mouse-sized mammal that lived during the Jurassic Period.

The Great Elephant Census /biointeractive/the-great-elephant-census Scientists at Work Conservation biology, Communities, Populations, Statistics and math, Scientific methodology Thursday, June 9, 2016 - 2:48pm

How many African elephants are left and where are they? This video follows the work of researchers conducting the first census of African savanna elephants in over 40 years and the methods they are using to obtain accurate, up-to-date numbers across the continent. 

Survey Methods /biointeractive/survey-methods Click & Learn Populations, Conservation biology, Animals, Scientific methodology, Statistics and math Thursday, June 9, 2016 - 2:59pm

In this interactive, students explore the methods scientists use to survey elephants and learn about the current state of the elephant population in Africa.

CSI Wildlife /biointeractive/csi-wildlife Click & Learn Populations, Conservation biology, DNA, Population genetics, Scientific methodology, Biotechnology Friday, June 10, 2016 - 8:59am

In this interactive, students use DNA profiling, or fingerprinting, to solve two cases of elephant poaching. In the process they will learn about genetic markers, PCR, gel electrophoresis, allele frequencies, and population genetics.

Fellowship of the Rings /biointeractive/fellowship-rings Image of the Week Proteins, Nucleic acids, Virus, Cell structure Monday, June 13, 2016 - 2:29pm

The nuclear pore is a complex of three rings of proteins that controls the passage of materials in and out of the nucleus.

Using Genetic Evidence to Identify Ivory Poaching Hotspots /biointeractive/using-genetic-evidence-to-identify-ivory-poaching-hotspots Data Point Conservation biology, Populations, Population genetics, DNA, Statistics and math, Scientific methodology Monday, June 20, 2016 - 3:17pm

A team of scientists analyzed the DNA from seized ivory to determine where the ivory from poached elephants came from.

Selective Breeding in Maize /biointeractive/selective-breeding-in-maize Data Point Artificial selection, Plants, Statistics and math, Scientific methodology Wednesday, June 22, 2016 - 4:02pm

Researchers performed the longest-running, controlled artificial selection experiment to study whether they could increase the protein concentration of maize (corn) by selective breeding.

Alzheimer’s Disease: Piecing Together the Evidence /biointeractive/alzheimers-disease-piecing-together-evidence Click & Learn Genetic basis of disease, Neuroscience Monday, June 27, 2016 - 1:03pm

This interactive explores evidence from brain anatomy, tissue histology, and genetic studies to reveal possible targets for the treatment of Alzheimer’s disease.

Undersea Fireworks /biointeractive/undersea-fireworks Image of the Week Behavior, Cell structure, Cell signaling Monday, July 4, 2016 - 3:22pm

The tentacles of sea anemones contain thousands of stinging cells called nematocysts that are ready to fire for defense or attack. 

Virus Hunter: Monitoring Nipah Virus in Bat Populations /biointeractive/virus-hunter-monitoring-nipah-virus-bat-populations Scientists at Work Virus, Infectious disease, Scientific methodology Wednesday, August 3, 2016 - 12:53pm

In this video we follow scientists working in Bangladesh as they test fruit bat populations to determine whether they are infected with Nipah virus—a potentially deadly virus when passed on to humans.

Virus Explorer /biointeractive/virus-explorer Click & Learn Virus, Infectious disease Wednesday, August 3, 2016 - 7:50pm

Explore the similarities and differences of a variety of viruses by sorting them based on structure, genomic make-up, host range, transmission mechanism, and vaccine availability.

Film Guide for Some Animals are More Equal than Others /biointeractive/film-guide-for-some-animals-are-more-equal-than-others Film Guide Ecosystems, Communities, Populations, History of science, Scientific methodology Thursday, August 11, 2016 - 10:13am

The following classroom-ready resources complement the film Some Animals Are More Equal Than Others: Trophic Cascades and Keystone Species. It tells the story of the bold experiments by Robert Paine and James Estes, which established the importance of keystone species in regulating ecological communities and the cascades of effects set in motion by their removal.

Discovering Keystone Species /biointeractive/discovering-keystone-species Poster Ecosystems, Communities, Populations, History of science, Scientific methodology Thursday, August 11, 2016 - 1:11pm

This classroom poster illustrates Robert Paine’s pioneering experiment that demonstrated the importance of top-down regulation of ecological communities by predators and led to his coining of the term keystone species.

Thermoregulation in Dinosaurs /biointeractive/thermoregulation-in-dinosaurs Data Point Evolutionary theory, Circulation, Statistics and math, Scientific methodology Monday, August 15, 2016 - 2:24pm

Grady and colleagues compared dinosaur fossil evidence with evidence from living animal species to shed more light on the type of thermoregulation that dinosaurs used—ectothermy, endothermy, or mesothermy.

Zebrafish Brain Cells for Spontaneous Navigation /biointeractive/zebrafish-brain-cells-spontaneous-navigation Image of the Week Developmental biology, Neuroscience, Cell signaling Monday, August 22, 2016 - 12:34pm

The brain and part of the spinal cord of a one-week-old zebrafish, showing neurons that are active during a left turn (green), a right turn (red), or when swimming straight ahead (blue)

Following the Matriarch /biointeractive/following-matriarch Image of the Week Conservation biology, Populations, Behavior Monday, August 29, 2016 - 1:31pm

A herd of elephants moving across the floodplain grassland of Gorongosa National Park.

Biological Basis of a Myth /biointeractive/biological-basis-myth Image of the Week Developmental biology, Neuroscience, Cell growth and division, Stem cells Monday, September 5, 2016 - 2:37pm

Hydra is a small freshwater hydrozoan polyp that has the capacity to grow a new individual from any part of its body.

Human Impacts on Biodiversity /biointeractive/human-impacts-biodiversity Activity Ecosystems, Communities, Biodiversity, Animals, Human impacts, Statistics and math Friday, September 9, 2016 - 1:17pm

In this activity, students will use trail camera data to answer a scientific research question about the impacts of humans on species diversity in Gorongosa.

Finding A Place On The Tree /biointeractive/finding-place-tree Image of the Week Speciation, Phylogeny and classification, Biodiversity Monday, September 12, 2016 - 11:46am

Dendrogramma is a newly-discovered species of deep sea siphonophore.

Exploring Trophic Cascades /biointeractive/exploring-trophic-cascades Click & Learn Ecosystems, Communities, Populations Tuesday, September 13, 2016 - 8:52am

This interactive explores examples of what can happen when there are changes in the population size of one species in an ecosystem. How are species at other trophic levels affected? How does the ecosystem change?

Dead Zones in Coastal Ecosystems /biointeractive/dead-zones-coastal-ecosystems Data Point Ecosystems, Human impacts, Statistics and math, Scientific methodology Monday, September 19, 2016 - 1:55pm

Researchers overlaid the locations of more than 400 hypoxic systems linked to eutrophication on a map of the global “human footprint.”

Zebrafish and Skin Color /biointeractive/zebrafish-and-skin-color Activity Human evolution, DNA, Gene expression, Skin, muscles, and bones Thursday, September 22, 2016 - 9:26am

This lesson complements the film The Biology of Skin Color and explores how experimental work in zebrafish led to a better understanding of the role of the gene SLC24A5 in human skin color.

Understanding Variation /biointeractive/understanding-variation Activity Human evolution, DNA, Gene expression, Skin, muscles, and bones Thursday, September 22, 2016 - 9:36am

This lesson complements the film The Biology of Skin Color and discusses variation in human skin color and polygenic inheritance. Also available in Spanish.

Selection for Tuskless Elephants /biointeractive/selection-tuskless-elephants Scientists at Work Natural selection, Conservation biology, Animals Friday, September 23, 2016 - 8:30am

Working in Gorongosa National Park, Mozambique, Dr. Joyce Poole and colleagues made a striking observation: many female elephants lack tusks.

Expanding Cells /biointeractive/expanding-cells Image of the Week Cell structure, Cell growth and division, Scientific methodology Monday, September 26, 2016 - 12:12pm

Using a new technique called expansion microscopy, scientists are able to see more details in their specimens.

The Great Elephant Census Modeling Activity /biointeractive/great-elephant-census-modeling-activity Activity Populations, Scientific methodology, Statistics and math Tuesday, September 27, 2016 - 1:44pm

In this classroom activity, students will model two types of counting methods, sample counts and total counts, to determine population size. 

Ultrasonic Evolution /biointeractive/ultrasonic-evolution Image of the Week Paleobiology, Phylogeny and classification, Neuroscience Monday, October 3, 2016 - 9:08pm

The inner ear of a 13-million-year-old shark-toothed dolphin.

Ecology of Rivers and Coasts—Food Webs and Human Impacts /biointeractive/ecology-of-rivers-and-coasts-food-webs-and-human-impacts Lecture Ecosystems, Communities, Populations Tuesday, October 4, 2016 - 5:39pm

Two leading ecologists describe the complex interactions between species and their environment in aquatic ecosystems. 

Mass Extinctions: Lessons from the Past /biointeractive/mass-extinctions-lessons-past Apps and eBooks Evolutionary theory, Paleobiology, Earth history, Human impacts Wednesday, October 5, 2016 - 6:09pm

Examine the history and causes of past mass extinctions, and the evidence for whether we are facing a sixth mass extinction, with this interactive eBook.

Tagging Bumble Bees to Study Their Movements /biointeractive/tagging-bumble-bees-study-their-movements Scientists at Work Biodiversity, Scientific methodology Friday, October 7, 2016 - 11:53am

Graduate student Jeremy Hemberger designs an experiment to study the foraging behavior of bumble bees in different habitats.

The Effects of Fungicides on Bumble Bee Colonies /biointeractive/effects-fungicides-bumble-bee-colonies Scientists at Work Biodiversity, Fungi, Scientific methodology Friday, October 7, 2016 - 11:56am

Are fungicides safe for bumble bees? Entomologist Shawn Steffan designed an experiment to answer this question.

Trophic Cascades in Rivers /biointeractive/trophic-cascades-rivers Lecture Ecosystems, Communities, Populations Thursday, October 13, 2016 - 10:04am

How fishes in a river ecosystem play a critical role in forming the aquascape.

Untangling Salt Marsh Food Webs /biointeractive/untangling-salt-marsh-food-webs Lecture Ecosystems, Communities, Populations Thursday, October 13, 2016 - 10:07am

The revelation that salt marshes are controlled by top-down forces of herbivores and other consumers.

Floods, Droughts, and Food Chains /biointeractive/floods-droughts-and-food-chains Lecture Ecosystems, Communities, Populations Thursday, October 13, 2016 - 10:11am

How a river's community of herbivores and predators is affected by changes in river flow.

Climate Stress and Coastal Food Webs /biointeractive/climate-stress-and-coastal-food-webs Lecture Ecosystems, Communities, Populations Thursday, October 13, 2016 - 10:31am

We are in the midst of a major die-off of coastal wetlands – what is to blame?

A Model Microbe /biointeractive/model-microbe Image of the Week Protists, RNA, Cell structure Monday, October 17, 2016 - 9:29am

Tetrahymena thermophila is a freshwater unicellular ciliated protozoan related to Paramecium.

Patterns of Zoonotic Disease /biointeractive/patterns-of-zoonotic-disease Data Point Virus, Infectious disease, Statistics and math, Scientific methodology Monday, October 24, 2016 - 1:37pm

In this study, scientists analyzed previously published data on terrestrial mammal zoonotic host species and the pathogens they carry to search for global patterns of zoonotic disease distribution.

Spooky Sedge /biointeractive/spooky-sedge Image of the Week Plants, Cell structure, History of science Monday, October 31, 2016 - 8:12pm

Oh the horror! A cross-section of the stem of yellow nut sedge plant (Cyperus esculentus)

How Animals Use Sound to Communicate /biointeractive/how-animals-use-sound-communicate Click & Learn Natural selection, Animals, Neuroscience, Behavior, Statistics and math Wednesday, November 2, 2016 - 10:22am

Using elephants, finches, bats, and moths, as case studies, explore different aspects of how animals use sound to communicate.

Teeth of the Skin /biointeractive/teeth-skin Image of the Week Mechanisms of evolution, Gene expression, Skin, muscles, and bones Monday, November 7, 2016 - 9:07am

The head of a newly-hatched catshark (Scyliorhinus canicula) imaged using 3D X-ray microscopy.

Genetically Modified Mosquitoes /biointeractive/genetically-modified-mosquitoes Scientists at Work Virus, Gene expression, Biotechnology Monday, November 14, 2016 - 9:07am

Learn the process by which a line of genetically modified mosquitoes was engineered to reduce populations of Aedes aegypti mosquitoes in the wild.

Eat Your Vitamins /biointeractive/eat-your-vitamins Image of the Week Chemistry, Nutrition, Cell growth and division Monday, November 14, 2016 - 2:37pm

Ascorbic acid, or Vitamin C, is an essential component of the human diet.

Relish the Cranberry /biointeractive/relish-cranberry Image of the Week Ecosystems, Plants, Human impacts Monday, November 21, 2016 - 2:31pm

Most of the cranberries used for Thanksgiving dinner are “wet harvested” by flooding cranberry marshes.

Dating Corn Domestication Using Carbon Isotopes /biointeractive/dating-corn-domestication-using-carbon-isotopes Data Point Paleobiology, Plants, Statistics and math, Scientific methodology Monday, November 28, 2016 - 12:20pm

To study the change in diet as human populations changed lifestyles from hunter-gatherers to agriculturalists, scientists measured carbon isotopes in the collagen tissues of human skeletons from North America.

Genetic Mutations and Disease Interactive /biointeractive/genetic-mutations-and-disease-interactive Click & Learn Genetic basis of disease, Developmental biology, Cell growth and division Tuesday, November 29, 2016 - 11:28am

This interactive focuses on the roles of germline and somatic cell mutations in human disease. It supports the 2013 Holiday Lectures on Science, Medicine in the Genomic Era.

Sharklab /biointeractive/sharklab Image of the Week Ecosystems, Biodiversity, Behavior Monday, December 5, 2016 - 3:40pm

A team of scientists from The Bimini Biological Field Station collecting samples from a male tiger shark (Galeocerdo cuvier).

Designer Proteins /biointeractive/designer-proteins Image of the Week Biochemistry, Proteins, Gene expression Monday, December 12, 2016 - 5:54pm

Scientists are custom-designing proteins, like these nanocages with many green fluorescent proteins attached

Ebola: Disease Detectives /biointeractive/ebola-disease-detectives Activity Virus Wednesday, December 14, 2016 - 10:45am

In this classroom activity, students will analyze sequences of Ebola viruses isolated from patients in Sierra Leone during the Ebola outbreak of 2013–2016 to track the virus spread. Also available in Spanish.

Under the Hemiparasite /biointeractive/under-hemiparasite Image of the Week Biodiversity, Plants, Photosynthesis Monday, December 19, 2016 - 9:50am

Many of the 1400 or so species of mistletoes are hemiparasites—they obtain at least part of their nutrition from the host tree.

BiomeViewer /biointeractive/biomeviewer Click & Learn, Apps and eBooks Ecosystems, Biodiversity, Climate, Human impacts Thursday, October 19, 2017 - 3:50pm

An interactive to explore biomes, climate, biodiversity, and human impacts across the globe.

DNA Profiling Activity /biointeractive/dna-profiling-activity Activity Mendelian inheritance, DNA, Biotechnology Thursday, December 22, 2016 - 11:19am

This multi-part lesson is designed to give students a firm understanding of genetic profiling using short tandem repeats (STRs), which is a process used by forensics labs around the world. 

Seeing In the New Year /biointeractive/seeing-new-year Image of the Week Developmental biology, Neuroscience, Cell growth and division Monday, January 2, 2017 - 9:07am

Multi-color labeling of photoreceptor neurons in the developing visual system of the fruit fly (Drosophila melanogaster).

Think Like a Scientist: Natural Selection in an Outbreak /biointeractive/think-like-a-scientist-natural-selection-in-an-outbreak Scientists at Work Natural selection, Virus, Genomics, Infectious disease Tuesday, January 3, 2017 - 10:36am

This video brings us to the front lines of the 2013–2015 Ebola outbreak in west Africa and explains how scientists monitored the evolution of the virus by analyzing its genome.

Bat Echolocation /biointeractive/bat-echolocation Data Point Animals, Behavior, Statistics and math, Scientific methodology Monday, January 9, 2017 - 12:41pm

In this study, researchers tested whether bats change their behavior while hunting based on feedback from echolocation.

Deadly Straw /biointeractive/deadly-straw Image of the Week Virus, Protists, Infectious disease Monday, January 16, 2017 - 1:16pm

Blood cells adorn the proboscis of a female mosquito.

Sound and Vision /biointeractive/sound-and-vision Image of the Week Chemistry, Circulation, Cancer Monday, January 23, 2017 - 2:22pm

A mass of cells surrounded by blood vessels visualized in a living mouse using photoacoustic imaging.

HIV Receptors and Co-receptors /biointeractive/hiv-receptors-and-co-receptors Activity Proteins, Virus, Infectious disease Monday, February 6, 2017 - 10:28am

This demonstration models the first step of the HIV life cycle: the binding of HIV envelope proteins to receptors on human helper T cells.

HIV Reverse Transcription and AZT /biointeractive/hiv-reverse-transcription-and-azt Activity Proteins, Virus, Infectious disease Monday, February 6, 2017 - 11:09am

Students model how the anti-HIV drug AZT (azidothymidine) interferes with the process of viral replication.

Viral DNA Integration /biointeractive/viral-dna-integration Activity Proteins, Virus, Infectious disease Monday, February 6, 2017 - 11:20am

In this hands-on activity, students model how a double-stranded DNA copy of the HIV genome is integrated into the host cell DNA.

Cell Division and Cancer Risk /biointeractive/cell-division-and-cancer-risk Data Point Cancer, Cell growth and division, Statistics and math, Scientific methodology Monday, February 6, 2017 - 2:40pm

Cancer is typically attributed to hereditary and environmental factors, but these only explain a fraction of overall cancer risk. In this study, researchers investigated how a third factor—chance genetic mutations that occur during stem cell division—may contribute to the overall rate of cancer incidence in different body tissues.

HIV Protease Inhibitors /biointeractive/hiv-protease-inhibitors Activity Proteins, Virus, Infectious disease Monday, February 6, 2017 - 3:54pm

This demonstration models how the HIV protease enzyme functions and how its activity is blocked by a class of anti-HIV drugs.

Viral Lysis and Budding /biointeractive/viral-lysis-and-budding Activity Virus, Infectious disease Tuesday, February 7, 2017 - 12:27pm

This activity outlines two demonstrations that model how enveloped and nonenveloped viruses are released from infected cells.

Tugging The Cellular Heartstrings /biointeractive/tugging-cellular-heartstrings Image of the Week Skin, muscles, and bones, Circulation, Cell structure Monday, February 13, 2017 - 3:21pm

The microtubules inside cardiomyocytes buckle when the heart contracts.

Studying Elephant Communication /biointeractive/studying-elephant-communication Scientists at Work Animals, Behavior, Scientific methodology Thursday, February 16, 2017 - 9:08am

Elephants can communicate over long distances using low-frequency sounds that travel both in the air and through the ground. Scientists are studying whether elephants can “hear” and interpret these ground vibrations.

Spiny Cells /biointeractive/spiny-cells Image of the Week Neuroscience, Cell structure, History of science Monday, February 20, 2017 - 5:54pm

A drawing, made by Santiago Ramón y Cajal of pyramidal neurons in the cerebral cortex of a rabbit, documented the presence of dendritic spines on the surfaces of some of the cells.

Tracking Global Changes in Forest Cover /biointeractive/tracking-global-changes-in-forest-cover Data Point Ecosystems, Human impacts, Statistics and math, Scientific methodology Monday, February 27, 2017 - 3:20pm

Researchers used satellite imagery analyze the amount of forest that was lost annually across the globe between 2000 and 2012.

Red Tattoo /biointeractive/red-tattoo Image of the Week Skin, muscles, and bones, Cell structure, Science and society Monday, March 6, 2017 - 9:48am

A section of stained human skin bearing a red tattoo.

Wash Your Hands /biointeractive/wash-your-hands Image of the Week Virus, Infectious disease, Scientific methodology Monday, March 13, 2017 - 2:51pm

As few as eighteen of these norovirus particles are sufficient to infect one person.

Lionfish Invasion /biointeractive/lionfish-invasion Image of the Week Ecosystems, Conservation biology, Human impacts Monday, March 20, 2017 - 5:40pm

Two species of lionfish, the red lionfish (Pterois volitans) and the common lionfish (Pterois miles), have been established as invasive species off the East Coast of the United States and in the Caribbean.

Snail Fronts and Salt Marsh Die-Offs /biointeractive/snail-fronts-and-salt-marsh-die-offs Data Point Ecosystems, Human impacts, Statistics and math, Scientific methodology Monday, March 27, 2017 - 3:16pm

Researchers studied whether periwinkle snail fronts expand mudflats and contribute to salt marsh die-offs.

Ecology, Food Webs, and the Chesapeake Bay /biointeractive/ecology-food-webs-and-chesapeake-bay Lecture Conservation biology, Ecosystems, Human impacts Monday, April 3, 2017 - 11:03am

A discussion of the Chesapeake Bay Watershed, its complex food web, and the challenges of conserving and restoring the bay.

Super Stoma /biointeractive/super-stoma Image of the Week Natural selection, Biodiversity, Plants, Photosynthesis Monday, April 3, 2017 - 3:20pm

The stomata of grasses (singular stoma) function more efficiently than those of other plants.

Who Am I? /biointeractive/who-am-i Image of the Week Mechanisms of evolution, Natural selection, History of science Monday, April 17, 2017 - 11:20am

The caterpillar of the spicebush swallowtail butterfly (Papilio trollus) mimics the rough green snake (Opheodrys aestivus).

Mimicry in a Diverse Community of Arthropods /biointeractive/mimicry-in-a-diverse-community-of-arthropods Data Point Mechanisms of evolution, Statistics and math, Scientific methodology Monday, April 24, 2017 - 5:46pm

Researchers exposed arthropod mimics that use a golden patch to warn of unpalatability to predators with different prey preferences to determine how effective their warnings were.

Patterns in the Distribution of Lactase Persistence /biointeractive/patterns-distribution-lactase-persistence Activity Evolution of populations, Human evolution, Population genetics Friday, April 28, 2017 - 9:23am

Students explore the geographic distribution of lactase persistence around the world by analyzing real data collected by scientists.

Riverine Food Webs – How Flow Rates Affect Biomass /biointeractive/riverine-food-webs-how-flow-rates-affect-biomass Scientists at Work Ecosystems, Scientific methodology Monday, May 1, 2017 - 12:29pm

Ecologist Mary Power studies the Eel River in Northern California to figure out the connection between river flows and biodiversity.

Larval Biscuit /biointeractive/larval-biscuit Image of the Week Speciation, Biodiversity, Developmental biology Monday, May 1, 2017 - 1:37pm

A pluteus larva of the sea biscuit, Clypeaster subdepressus, an echinoderm closely related to sea urchins.

Trophic Cascades in Salt Marsh Ecosystems /biointeractive/trophic-cascades-salt-marsh-ecosystems Scientists at Work Ecosystems, Scientific methodology Friday, May 5, 2017 - 10:37am

Ecologist Brian Silliman uses manipulative field experiments to reveal that salt marsh ecosystems are under top down control from consumers and predators.

Single Mother /biointeractive/single-mother Image of the Week Conservation biology, Ecosystems, Developmental biology Monday, May 8, 2017 - 12:53pm

A queen bee may produce as many as 60,000 offspring during her lifetime.

Modeling Trophic Cascades /biointeractive/modeling-trophic-cascades Activity Ecosystems, Animals Wednesday, May 10, 2017 - 12:41pm

Students use cards of animal and plant species to model trophic cascades. Species examples are drawn from seven different habitats to test student understanding.

Dragon Tale /biointeractive/dragon-tale Image of the Week Biodiversity, Conservation biology, Animals Monday, May 15, 2017 - 12:45pm

A pangolin rescued from poachers near Gorongosa National Park, Mozambique.

Sleep Clears β-amyloid from the Brain /biointeractive/sleep-clears-v-amyloid-from-the-brain Data Point Neuroscience, Statistics and math, Scientific methodology Monday, May 22, 2017 - 2:11pm

The researchers in this study tested whether the rate of Aβ removal is higher during sleep using mice as model organisms.

Counting the Rings /biointeractive/counting-rings Image of the Week Populations, Neuroscience, Cell growth and division Monday, May 29, 2017 - 11:34am

An otolith from a lanternfish (Gymnoscopelus nicholsi) is used to estimate the fish’s age and growth rate.

WildCam Darién /biointeractive/wildcam-darien Click & Learn Communities, Biodiversity, Conservation biology, Animals, Scientific methodology Monday, June 5, 2017 - 2:27pm

Researchers in Darién and Soberanía National Parks use remote trail cameras to study jaguars and their prey. You can contribute to this important research through WildCam Darién, an online citizen science platform.

Root Movement /biointeractive/root-movement Phenomenal Image Plants, Stem cells, Photosynthesis Monday, June 5, 2017 - 8:46pm

Students explore photos of plant cells as an anchoring phenomenon to explore the response of plant cells to stimuli.

Seed Dispersal and Habitat Fragmentation /biointeractive/seed-dispersal-and-habitat-fragmentation Scientists at Work Conservation biology, Biodiversity, Plants, Human impacts Wednesday, June 7, 2017 - 9:16am

Watch researchers follow brown spider monkeys in a tropical forest of Colombia to determine which plant seeds they are dispersing. Seed dispersers are critical to the forest’s ability to grow and regenerate. 

Dad Feathers /biointeractive/dad-feathers Image of the Week Natural selection, Reproduction, Behavior Monday, June 12, 2017 - 9:08pm

The male peafowl, or peacock, invests a lot in his appearance.

How Lizards Find Their Way Home /biointeractive/how-lizards-find-their-way-home Scientists at Work Animals, Behavior, Scientific methodology Wednesday, June 14, 2017 - 3:19pm

When Dr. Manuel Leal removed lizards from an area in the forest, he noticed an interesting phenomenon: all the lizards seemed to be back the next day. Watch as he sets up an experiment to study how these lizards navigate home. Also available in Spanish.

Using Wolbachia to Suppress Mosquito Fertility /biointeractive/using-wolbachia-to-suppress-mosquito-fertility Data Point Bacteria, Statistics and math, Scientific methodology Monday, June 19, 2017 - 3:37pm

In this study, researchers tested whether releasing Wolbachia-infected male Aedes albopictus (Asian tiger mosquitoes) would suppress populations of this mosquito species in their study area.

Asteroid Impact? /biointeractive/asteroid-impact Image of the Week Biosphere, Chemistry, Earth processes Monday, June 26, 2017 - 3:02pm

A living foraminifer, Orbulina universa, in the act of shortening its spines in preparation for gametogenesis.

Firefly Pyrotechnics /biointeractive/firefly-pyrotechnics Image of the Week Biodiversity, Biochemistry, Behavior Wednesday, July 5, 2017 - 9:53am

Most firefly species employ characteristic patterns of bioluminescent flashes to elicit responses from potential mates.

Grandes transiciones: el origen de los humanos /node/168280 Short Film Paleobiology, Human evolution, Mechanisms of evolution, Skin, muscles, and bones Wednesday, August 9, 2017 - 2:08pm

¿Qué rasgos distinguen a los humanos del resto de los primates? ¿Dónde y cuándo evolucionaron estos rasgos? El análisis de los principales descubrimientos fósiles en África, que datan de hace 4.4 millones de años, responde estas interrogantes y revela la historia de nuestros orígenes evolutivos.

Grandes transiciones: el origen de las aves /node/168324 Short Film Paleobiology, Mechanisms of evolution, Skin, muscles, and bones, Scientific methodology Wednesday, August 9, 2017 - 5:39pm

En el segundo cortometraje de la trilogía titulada Grandes transiciones, la paleontóloga Julia Clarke nos lleva en un viaje para explorar la evidencia de que las aves descendieron de los dinosaurios.

Paleoclima: una historia de cambio /node/168330 Click & Learn Earth history, Climate Wednesday, August 9, 2017 - 5:54pm

El clima de la Tierra es un sistema complejo controlado por muchos factores. Este “Click and Learn” examinará los dos factores más importantes: la radiación solar y la composición de la atmósfera de la Tierra.

Ebola: detectives de enfermedades /node/168334 Activity Virus Wednesday, August 9, 2017 - 6:05pm

En esta actividad los estudiantes analizarán las secuencias de Ebola obtenidas de pacientes en Sierra Leona durante el brote de 2013-2016 para monitorear la propagación del virus.

El día que murió el Mesozoico /node/168403 Short Film Paleobiology, Chemistry, Earth history, History of science, Scientific methodology Thursday, August 10, 2017 - 4:00pm

La desaparición de los dinosaurios al final del período Cretácico planteó uno de los misterios científicos más grandes y perdurables. Esta película, organizada en tres actos, relata la historia del extraordinario trabajo detectivesco que resolvió el misterio.

Usando ADN para construir filogenias /node/168404 Activity Phylogeny and classification, Biodiversity, Bioinformatics, DNA, Behavior, Scientific methodology Thursday, August 10, 2017 - 4:18pm

Esta actividad complementa al cortometraje El origen de las especies: Lagartijas en un árbol evolutivo. A los estudiantes se les pide clasificar a las especies de lagartijas por su aspecto, y luego generar un árbol filogenético usando secuencias de ADN para evaluar si las especies parecidas están estrechamente emparentadas entre sí.

El origen de las especies: lagartijas en un árbol evolutivo /node/168408 Short Film Speciation, Phylogeny and classification, DNA, Behavior Thursday, August 10, 2017 - 4:33pm

En las islas del Caribe, la adaptación de un grupo de lagartijas a varios hábitats ha dado lugar a una radiación adaptativa, con interesantes ejemplos de evolución convergente.

Benefits of Schools /biointeractive/benefits-schools Phenomenal Image Ecosystems, Populations, Behavior Monday, August 14, 2017 - 12:35pm

Students explore photos of animals in groups as anchoring phenomena to explore animal behavior concepts.

Portrait of a Howler /biointeractive/portrait-howler Image of the Week Populations, Behavior, History of science Monday, August 14, 2017 - 12:59pm

Groups of black howler monkeys (Alouatta caraya) “howl” to each other in the Amazon rainforest during the evening and early morning hours in order to maintain neighborly distances.

La biología del color de la piel /node/168553 Short Film Human evolution, DNA, Gene expression, Skin, muscles, and bones Tuesday, August 15, 2017 - 10:44am

La antropóloga de la Universidad Penn State, Dra. Nina Jablonski, nos muestra la evidencia de que los distintos tonos de color de piel en poblaciones humanas surgieron como adaptaciones a la intensidad de los rayos ultravioleta en distintas partes del mundo.

Selección natural en humanos /node/168556 Short Film Human evolution, Mendelian inheritance, Genetic basis of disease, Infectious disease Tuesday, August 15, 2017 - 12:31pm

En algunas partes del mundo existe una conexión íntima entre una enfermedad parasítica, la malaria, y una enfermedad genética, la anemia falciforme.

Population Dynamics /biointeractive/population-dynamics Click & Learn Populations, Statistics and math Tuesday, August 15, 2017 - 3:08pm

Explore the exponential and the logistic growth mathematical models that describe how population changes with time.

Microbial Community Response to an Oil Spill /biointeractive/microbial-community-response-to-an-oil-spill Data Point Communities, Bacteria, Human impacts, Statistics and math, Scientific methodology Wednesday, August 16, 2017 - 10:12am

Researchers monitored the succession of the microbial community in the Gulf of Mexico using data from before, during, and after the Deepwater Horizon oil spill.

El origen de las especies: construyendo una teoría /node/168622 Short Film Evolutionary theory, History of science, Science and society Thursday, August 17, 2017 - 8:42am

Los viajes épicos de Darwin y Wallace llevaron a cada uno de ellos a descubrir de manera independiente el origen natural de las especies, y a formular la teoría de la evolución mediante selección natural.

La doble hélice /node/168623 Short Film Nucleic acids, DNA, History of science Thursday, August 17, 2017 - 10:31am

La doble hélice es la historia de los científicos y la evidencia en la búsqueda científica más importante del siglo XX: el descubrimiento de la estructura del ADN.

¿Tienes lactasa? La co-evolución de genes y cultura /node/168624 Short Film Human evolution, Gene expression, Gene regulation, Nutrition Thursday, August 17, 2017 - 10:45am

Sigue al genetista Spencer Wells, Director del Proyecto Geográfico de la National Geographic Society, mientras le sigue la pista a los cambios genéticos asociados con la capacidad de los adultos para digerir la lactosa.

Vida animada: al ver lo invisible /node/168625 Animated Short Animals, Bacteria, Protists, Cell signaling, History of science Thursday, August 17, 2017 - 10:55am

Este cortometraje animado celebra al ciudadano-científico del siglo XVII, Antoine van Leeuwenhoek, cuyo descubrimiento de los microbios cambió nuestra percepción del mundo biológico.

Selección natural y adaptación /node/168626 Short Film Mechanisms of evolution, Natural selection Thursday, August 17, 2017 - 11:12am

El ratón de bolsillo es un ejemplo viviente del proceso de selección natural de Darwin.

Estalló el secreto: el misterioso origen del maíz /node/168627 Short Film Paleobiology, Artificial selection, Plants, Gene regulation Thursday, August 17, 2017 - 11:20am

¿De dónde vino el maíz? Datos genéticos y arqueológicos apuntan hacia lo que podría parecer un ancestro improbable: un pasto silvestre en México, llamado teosinte.

El guía: un biólogo en Gorongosa /node/168628 Short Film Conservation biology, Biodiversity, Human impacts, Careers in science, Science and society Thursday, August 17, 2017 - 11:27am

Con la restauración del Parque Nacional Gorongosa en Mozambique como telón de fondo, El guía relata la historia de un joven de una comunidad local quien descubre su pasión por la ciencia luego de conocer al biólogo de fama mundial, E.O. Wilson

Repartición de nichos y co-existencia de las especies /node/168629 Scientists at Work Ecosystems, Biodiversity, Scientific methodology Thursday, August 17, 2017 - 12:16pm

El investigador Robert Pringle describe el método de metabarcoding del ADN, utilizado para revelar cómo animales similares comparten recursos.

Analizando patrones en la sabana Africana /node/168630 Scientists at Work Ecosystems, Statistics and math, Scientific methodology Thursday, August 17, 2017 - 12:23pm

La Dra. Corina Tarnita, matemática devenida en bióloga, describe la importancia de los termiteros en los ecosistemas de sabana.

Tracking Genetically Modified Mosquitoes /biointeractive/tracking-genetically-modified-mosquitoes Activity Populations, Statistics and math, Scientific methodology, Biotechnology Friday, August 18, 2017 - 3:23pm

Genetically modified mosquitoes have been used to reduce mosquito populations and the diseases they spread. But how can we tell if the method works? In this activity, students analyze data from a field experiment.

El ciclo celular eucarionte y el cáncer /node/169149 Click & Learn Genetic basis of disease, Cancer, Cell growth and division, Cell signaling Friday, August 25, 2017 - 9:44am

Explora las fases, puntos de control y proteínas reguladoras del ciclo celular con esta herramienta “Click and Learn”. Esta es una plataforma altamente interactiva que te permite descubrir cómo versiones mutadas de estas proteínas pueden conducir al desarrollo de cáncer.

Control neural del caminar y el correr /node/169154 Click & Learn Neuroscience, Behavior, Skin, muscles, and bones Friday, August 25, 2017 - 9:55am

Explora los diferentes modos de andar utilizados por los animales, y cómo el sistema nervioso es capaz de controlar la transición entre distintos modos.

Usando el proceso científico para estudiar la evolución humana /node/169248 Click & Learn Paleobiology, Human evolution, Scientific meth