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Zhe Liu is interested in devising new strategies to study how biological systems establish precise spatial and temporal controls at the molecular level. Specifically, Liu and his team use a combination of advanced imaging, labeling, and genetic tools to quantitatively dissect structure-function relationships underlying information processing in the cell nucleus and on the neuron membrane. Through their collaborations at Janelia and with other scientists, the team is helping to decipher the molecular basis underlying cell physiology in the brain.