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Vamsi Mootha’s research focuses on mitochondria – organelles responsible for generating cellular energy that play a central role in apoptosis, ion homeostasis, metabolism, and biosynthesis. Working collaboratively with other researchers and clinicians, Mootha and his team combine modern tools of genomics and computation with classical biochemical physiology to study mitochondrial function in health and in disease. Their long-term goal is to use their findings to improve the diagnosis and treatment of a range of human diseases, from rare, inborn errors of metabolism to diabetes, neurodegeneration, and cancer.