HomeOur ScientistsSusan Lindquist

Our Scientists

Susan Lindquist, PhD
Investigator / 2006–Present

Host Institution

Whitehead Institute for Biomedical Research

Current Position

Dr. Lindquist is a member (and former director) of the Whitehead Institute for Biomedical Research, a professor of biology at the Massachusetts Institute of Technology, an associate member of the Broad Institute of MIT and Harvard, and an associate member of the David H. Koch Institute for Integrative Cancer Research at MIT. She was an HHMI investigator from 1988 to 2001 at the University of Chicago.

Current Research

The Surprising World of Protein Folding

Susan Lindquist's pioneering work in protein folding has demonstrated that alternative protein conformations have profound and unexpected effects in fields as wide ranging as human disease, evolution, and biomaterials. Her work on yeast prions has provided evidence for a mechanism of protein-only inheritance and contributed to a structural understanding of amyloid fiber formation. She has shown that molecular chaperones can influence the expression and evolution of new traits by chaperoning the folding of key players in signal transduction pathways. Her group has also developed yeast models to study protein-folding transitions in neurodegenerative diseases and to test therapeutic strategies.

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Amyloid fiber assembly...

Biography

Dr. Lindquist is also a member and former director of the Whitehead Institute for Biomedical Research, a professor of biology at the Massachusetts Institute of Technology, an associate member of the Broad Institute of MIT and Harvard, and an…

Dr. Lindquist is also a member and former director of the Whitehead Institute for Biomedical Research, a professor of biology at the Massachusetts Institute of Technology, an associate member of the Broad Institute of MIT and Harvard, and an associate member of the David H. Koch Institute for Integrative Cancer Research at MIT. Prior to this she was Albert D. Lasker Professor of Medical Sciences in the Department of Molecular Biology at the University of Chicago. She received her undergraduate degree in microbiology from the University of Illinois and a PhD in biology from Harvard University.

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Education

  • BA, microbiology, University of Illinois
  • PhD, biology, Harvard University

Awards

  • President's National Medal of Science
  • Mendel Medal, UK Genetics Society
  • Max Delbrück Medal, Max Delbrück Center for Molecular Medicine, Berlin
  • Stein and Moore Award, Protein Society
  • Genetics Society of America Medal
  • Sigma Xi William Procter Prize for Scientific Achievement
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Memberships

  • National Academy of Sciences
  • Institute of Medicine of the National Academies
  • American Philosophical Society
  • American Academy of Arts and Sciences
  • German Academy of Natural Sciences Leopoldina
  • American Academy of Microbiology
  • European Molecular Biology Organization
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