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Michael Welsh is interested in understanding the biology of cystic fibrosis (CF) and developing new treatments for the lethal genetic disease. Welsh and his team study regulation of the CFTR anion channel and how mutation alters its function in CF, as well as the pathogenesis of lung disease. In addition, the team studies the molecular biology and physiology of changes in brain pH and its effect on acid sensing ion channels and neural function. They are particularly interested in understanding the basis of fear memory and how that memory might be altered to treat people with PTSD.