Research Area
Cancer Biology, Developmental Biology
Related Links
Host Institution
University of Pennsylvania
Current Position
Dr. Simon is also Professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania and Scientific Director of the Abramson Family Cancer Research Institute.
Current Research
Hypoxia, Angiogenesis, and Tumor Progression
Celeste Simon studies the molecular mechanisms regulating oxygen homeostasis, stem cell maintenance, angiogenesis, and hematopoiesis. As the majority of tumors include cells that are oxygen deprived, responses to oxygen availability promote cancer cell survival, cancer stem cell phenotypes, and tumor angiogenesis. As such, oxygen-sensitive molecules are appropriate targets for anticancer therapy.
Vascular architecture of a mouse embryo...
Biography
Dr. Simon is also Professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania and Scientific Director of the Abramson Family Cancer Research Institute. She received her Ph.D. degree from the Rockefeller University and did postdoctoral research with Joseph Nevins at Rockefeller and with Stuart Orkin at Harvard Medical School. Before moving to Pennsylvania in 1999, Dr. Simon was an HHMI investigator at the University of Chicago.
Articles & News
Research Papers
Selected Research Papers
