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Our Scientists

Krishna K. Niyogi, PhD
Investigator / 2011–Present

Scientific Discipline

Biochemistry, Plant Biology


University of California, Berkeley

Current Position

Dr. Niyogi is a Howard Hughes Medical Institute–-Gordon and Betty Moore Foundation investigator. He is also a professor in the Department of Plant and Microbial Biology at the University of California, Berkeley and a faculty scientist in the Molecular Biophysics and Integrated Bioimaging Division at Lawrence Berkeley National Laboratory.

Current Research

Understanding and Improving Photosynthesis

Kris Niyogi studies photosynthetic energy conversion and its regulation in algae and plants.
False-color image of photosystem II efficiency in colonies of Chlamydomonas mutants...


Few people appreciate the love–hate relationship plants have with light better than Krishna Niyogi.

Too little light and plants can’t harvest enough energy to grow and reproduce. Too much and the machinery that powers photosynthesis goes…

Few people appreciate the love–hate relationship plants have with light better than Krishna Niyogi.

Too little light and plants can’t harvest enough energy to grow and reproduce. Too much and the machinery that powers photosynthesis goes into overdrive, releasing damaging, even lethal, by-products. That plants cover so much of the planet is testament to the coping mechanisms—studied by Niyogi for over a decade—that allow plants to thrive when their supply of sunlight is unsteady.

Niyogi first became interested in photosynthesis as a postdoc at the Carnegie Institution because there were so many unknowns: “There was room to make fundamental discoveries,” he says.

And he has. Niyogi’s lab at the University of California (UC), Berkeley, has elucidated the trade-offs plants make during photosynthesis by studying an alga and a flowering plant so distantly related that their last common ancestor lived hundreds of millions of years ago.

The amount of light in natural environments varies widely, on a timescale ranging from seconds to seasons. During photosynthesis, plants and green algae absorb light in the form of photons and, through a complex series of energy and electron transfers between molecules, use the light energy to convert carbon dioxide to sugars.

To make sure they capture light efficiently in low-light settings and avoid stress in sunny settings, plants and algae have evolved a variety of strategies. Some avoid shade or can adjust their capacity for absorbing light. Others regulate genes so fewer light-capturing proteins are produced when light is abundant, and more are produced when light is scarce.

Despite these defenses, many plants absorb more light than they can use, and Niyogi’s work has focused on one of their main lines of defense, a process known as nonphotochemical quenching (NPQ).

Like a safety valve on a steam engine, NPQ relieves plants of the burden of excess energy from light by releasing it as heat. NPQ was first described more than 20 years ago, but the mechanisms underlying it were poorly understood before Niyogi’s team used genetics to hone in on the problem. A full understanding of NPQ could help scientists improve it to develop more efficient biofuels and food crops that grow in a wider range of environments.

Niyogi’s lab has looked at NPQ in the flowering plant Arabidopsis and the green alga Chlamydomonas. While the mechanisms are similar, these species use different proteins to accomplish the task. Studying both model organisms has offered Niyogi a fuller picture of what’s possible in the natural world, since plants in different environments have evolved different strategies to make the best use of the conditions around them. Chlamydomonas, for example, can survive in darkness if given the right nutrients, so mutants with an impaired ability to photosynthesize can survive long enough to be studied.

His group bred thousands of plants and looked for genetic mutations that appeared to affect photosynthesis. The scientists painstakingly probed for anomalies in how the plants coped with too much or too little light and ultimately identified the first known mutants relevant to NPQ in both species. “That creative process for thinking of new genetic screens for mutants is one of the most exciting things in science,” Niyogi says. “It’s thrilling when it works.”

The mutants he isolated allowed Niyogi to define key molecules—the yellow pigments zeaxanthin and lutein—involved in NPQ. In a collaboration with physical chemist Graham Fleming, also at UC Berkeley, Niyogi explained the chemistry by which zeaxanthin facilitates the release of heat. Their work uncovering this mechanism was so elegant that it is now commonly found in plant biochemistry textbooks.

In a later paper, considered one of the most important contributions to understanding the regulation of photosynthesis in the past 20 years, Niyogi reported that Arabidopsis uses a protein called PsbS to detect, indirectly, when excess light is present and turn NPQ on or off accordingly. In a parallel discovery, Niyogi more recently showed that a protein called LHCSR plays a similar role in the green alga Chlamydomonas.

Niyogi plans to build on this work by asking how the various self-protective mechanisms in plants could be artificially improved and by developing mutants that switch NPQ on or off more quickly and others with improved capacity for photosynthesis in heavy sunlight. “I’d like to use some of the tools we’ve developed, having mutants with different enzymes as starting points. These are unproven ideas, so we don’t know if they will work or not,” says Niyogi, who has a joint appointment at the Department of Energy’s Lawrence Berkeley National Laboratory. But the payoff could be big if they do, given humanity’s ever-growing demands for food and fuel.

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  • BA, biology, The Johns Hopkins University
  • PhD, biology, Massachusetts Institute of Technology


  • Charles Albert Schull Award, American Society of Plant Biologists
  • Presidential Early Career Award for Scientists and Engineers (PECASE)


  • Member, National Academy of Sciences