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Eva Nogales studies the molecular function of macromolecular assemblies by direct visualization of their architecture, functional states, and regulatory interactions. Nogales and her team focus their efforts on two areas of eukaryotic biology in particular: regulatory mechanisms underlying gene expression and cytoskeleton self-assembly during cell division. To gain a molecular understanding of their systems of interest, the team uses cutting-edge cryo-electron microscopy methods and image analysis as well as biochemical and biophysical assays.