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Chris Doe studies the assembly of the nervous system in Drosophila, a process which begins with neural stem cells, called neuroblasts. Doe and his team examine how neuroblasts produce a diverse array of neurons, and how the neurons “wire up” to form circuits that generate locomotion and navigation behaviors. The team’s goal is to understand the developmental rules that underlie the assembly of neural circuits, which may someday help clinicians to direct human stem cells to form the precise types of neurons needed to repair injured or diseased brains.