RESEARCH NEWS
FROM HHMI

Making Mice Old Before Their Time
(01.27.06)
Knocking out a gene that helps repair nicks in DNA causes young mice to develop many of the degenerative characteristics of their wizened elders.

Switching off Aging in
Stem Cells
(09.06.06)
A single molecular switch plays a central role in inducing stem cells in the brain, pancreas, and blood to lose function as they age.

Researchers Identify Genes Role in Suppressing Longevity
(07.19.05)
HHMI researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide.

Researchers Uncover New Genes that Control Longevity
(11.18.05)
HHMI researchers and their colleagues have identified 10 new genes that regulate longevity in yeast.

Does Chromosome 4 Hold the Secret to Human Longevity?
(08.28.01)
A genetic study of more than 300 long-lived people suggests that chromosome 4 may harbor a secret about human longevity.

HHMI SCIENTISTS AND AGING

Frederick W. Alt

Sean J. Morrison

Stanley Fields

FROM THE HHMI BULLETIN

Secrets of the Centenarians
In certain families, small genetic variations bring good health and long life. Can researchers apply this knowledge to benefit us all?

FROM BIOINTERACTIVE

Stem Cells and the End of Aging

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HHMI Bulletin: Winter 2013

Cover Story: Rational Exuberance
A Nobelist shares the secrets to his longevity in the lab.

A Structural Revolution
A quarter century ago, structural biology hit a wall. HHMI created a way to break through.

One Foot in Front of the Other
Inside cells, specialized proteins march down a network of highways carrying machinery and messages. Researchers are learning how they manage it.

A Happy Oasis
Once Sangeeta Bhatia created her lab the way she wanted-as a supportive, intellectually challenging environment-the creative juices began to flow.