RESEARCH NEWS
FROM HHMI

Making Mice Old Before Their Time
(01.27.06)
Knocking out a gene that helps repair nicks in DNA causes young mice to develop many of the degenerative characteristics of their wizened elders.

Switching off Aging in
Stem Cells
(09.06.06)
A single molecular switch plays a central role in inducing stem cells in the brain, pancreas, and blood to lose function as they age.

Researchers Identify Genes Role in Suppressing Longevity
(07.19.05)
HHMI researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide.

Researchers Uncover New Genes that Control Longevity
(11.18.05)
HHMI researchers and their colleagues have identified 10 new genes that regulate longevity in yeast.

Does Chromosome 4 Hold the Secret to Human Longevity?
(08.28.01)
A genetic study of more than 300 long-lived people suggests that chromosome 4 may harbor a secret about human longevity.

HHMI SCIENTISTS AND AGING

Frederick W. Alt

Sean J. Morrison

Stanley Fields

FROM THE HHMI BULLETIN

Secrets of the Centenarians
In certain families, small genetic variations bring good health and long life. Can researchers apply this knowledge to benefit us all?

FROM BIOINTERACTIVE

Stem Cells and the End of Aging

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HHMI Bulletin: May 2008

Cover Story: Teaching Young Biologists New Tricks
Long the science where math mattered less, biology increasingly demands powerful quantitative skills. Teaching students the math they'll need, though, is more than just 1+1=2.

Invisible Barriers
Children with the subtlest form of autism suffer social isolation; those with more severe disease face a much tougher road. New genetic clues put the spotlight on the communication hubs of the brain's neurons–the synapses.

Genetic Balancing Act
Animals have evolved intricate ways to ensure that gene activity is the same in males and females despite the inherent imbalance of X chromosomes.

Sources of Renewal
As scientists learn more about how to produce and manipulate stem cells–amid high expectations and close scrutiny–no one is ready to choose any one approach over another.