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Dr. McFadden is professor at the University of Western Ontario and the Robarts Research Institute in London, Ontario, Canada. He received a Ph.D. (biochemistry) in 1975 from McGill University in Montreal. In 2001, he was named Canada Research Chair in Molecular Virology and, in 2002, he received the Hellmuth Prize. He was inducted as a fellow of the Royal Society of Canada in 2004. In 1997, McFadden cofounded Viron Therapeutics, Inc. (with Dr. A. Lucas) in London, Ontario, to explore the use of viral proteins for therapeutic purposes against inflammatory diseases. He continues to expand the portfolio of viral immune-modulating agents that can be derived from large DNA viruses and can deepen our understanding of viral pathogenesis and immune and inflammation-based mechanisms of disease.
RESEARCH ABSTRACT SUMMARY:
Grant McFadden is investigating the innate antiviral pathways activated during poxvirus infection in mammalian cells. These studies will define better the molecular mechanisms controlling host–virus species barriers and provide insights into host pathways that viruses circumvent to cause human zoonotic infections and will facilitate the development of poxviruses for oncolytic virotherapy.
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Photo: David Rolls
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