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Probing the Molecular and Cellular Basis of Developmental Morphogenesis

Research Summary

Anastasios Pavlopoulos is studying animal development at multiple levels of biological organization: from gene expression and function, to dynamic cell behaviors, to tissue and organ morphogenesis. To bridge these scales, he is using established and emerging arthropod model species that satisfy a number of appealing biological and technical requirements.

Figure: The crustacean model Parhyale hawaiensis.My doctoral and postdoctoral research focused primarily on applying functional genetic and genomic approaches in different arthropod models, including Drosophila melanogaster, Tribolium castaneum and Parhyale hawaiensis, to study the role of Hox genes in appendage development and evolution. These studies provided the entry point into my long-term research on the molecular and cellular mechanisms that control tissue and organ morphogenesis during animal development.

Having a strong experimental background in developmental genetics and molecular cell biology, I appreciate that the powerful synthesis of concepts and methodologies from biology, physics, and computer vision, as well as the interplay between theory and experiment, are necessary to fully comprehend the dynamics of developing living systems. Accordingly, my ongoing research couples functional genetic approaches with extensive multiview light-sheet microscopy recordings and sophisticated image analysis tools that will allow gene regulatory network dynamics, cell lineages, and a variety of cell behaviors to be analyzed in vivo during cell fate specification and in the context of developmental morphogenesis.

As of September 12, 2013

Scientist Profile

Janelia Fellow
Janelia Research Campus
Developmental Biology, Genetics