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Dr. Simon is also Professor of Cell and Developmental Biology at the University of Pennsylvania School of Medicine and Scientific Director of the Abramson Family Cancer Research Institute. She received her Ph.D. degree from the Rockefeller University and did postdoctoral research with Joseph Nevins at Rockefeller and with Stuart Orkin at Harvard Medical School. Before moving to Pennsylvania in 1999, Dr. Simon was an HHMI investigator at the University of Chicago.
RESEARCH ABSTRACT SUMMARY:
Celeste Simon studies the molecular mechanisms regulating oxygen homeostasis, stem cell maintenance, angiogenesis, and hematopoiesis. As the majority of tumors include cells that are oxygen deprived, responses to oxygen availability promote cancer cell survival, cancer stem cell phenotypes, and tumor angiogenesis. As such, oxygen-sensitive molecules are appropriate targets for anticancer therapy.
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Photo: Meagan Schofer
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