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Dr. Seidman is also Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics at Harvard Medical School. He received his undergraduate degree from Harvard University and his Ph.D. degree from the University of Wisconsin–Madison, where he studied with William McClain. His postdoctoral studies were carried out in Philip Leder's laboratory at the National Institute of Child Health and Human Development. Dr. Seidman is a recipient of the 2002 Bristol-Myers Squibb Award, which he shared with Christine Seidman.
RESEARCH ABSTRACT SUMMARY:
Jonathan Seidman is interested in the molecular causes of left ventricular hypertrophy, or thickening of the heart wall. Two different types of disease-causing mutations have been identified that cause this condition in humans. One involves sarcomere protein genes, and the other involves a gene encoding an AMP kinase subunit. Mice bearing altered genes have been created to model these human conditions, and the pathways by which these mutant genes cause disease are being dissected. These studies may eventually lead to new therapies for left ventricular hypertrophy.
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Photo: Kay Chernush
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