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Figure 2: Resolution of individual proteins in cell extracts by two-dimensional gel electrophoresis, visualized by silver staining. Arrows indicate proteins identified by peptide sequencing using mass spectrometry. In one study, human leukemia cells were analyzed for changes in protein mobility in response to MKK1 activation, identifying 20 new targets of MAP kinase pathway signaling (not shown).
Image: Timothy Lewis and Natalie Ahn.
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