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Carl Wu, Ph.D.
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Carl Wu is a senior fellow at Janelia Farm. Wu studies the molecular architecture of chromosomes and the role of chromatin structure in gene transcription—areas that are central to understanding how genomic information is programmed for selective expression in the development of the organism. Wu received his B.S. from St. Mary’s College and his Ph.D. in biology from Harvard University, where he began his study of chromatin organization under Sarah Elgin. While a Junior Fellow at Harvard under Wally Gilbert, Wu found that the chromatin of gene promoters is remodeled as DNase I hypersensitive sites. From Harvard, Wu moved to the National Cancer Institute where he investigated biochemical mechanisms of chromatin remodeling for three decades and served as Chief of the Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research. At Janelia, Wu is extending his work in new directions, developing fresh analytical methods for the epigenome and imaging local chromatin dynamics and large-scale chromatin folding in live cells.
RESEARCH ABSTRACT SUMMARY:
Carl Wu's laboratory uses biochemical and optical approaches to study the structure and function of chromatin, in particular the mechanisms by which chromatin controls access to and expression of eukaryotic genomes.
View Research Abstract
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