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Robert H. Singer, Ph.D.
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A senior fellow at Janelia Farm, Robert Singer uses a method to label endogenous mRNAs in living cells to study the expression and kinetics of RNA within cells and tissues. A pioneer of the idea that cells localize proteins by directing mRNAs to specific destinations, Singer is currently applying mRNA detection to the study of mRNA kinetics in brain tissue of transgenic mice. Singer holds a B.S. in physical chemistry from Oberlin College and a Ph.D. from Brandeis University in developmental biology. He did his postdoctoral work at the Massachusetts Institute of Technology and at the Weizmann Institute of Science in Rehovot, Israel. In addition to his Janelia appointment, Singer holds the following positions at the Albert Einstein College of Medicine: Professor and Cochair, Department of Anatomy and Structural Biology; Professor in the Dominick P. Purpura Department of Neuroscience and in Department of Cell Biology; and Codirector of the Gruss-Lipper Biophotonics Center.
RESEARCH ABSTRACT SUMMARY:
Rob Singer’s lab seeks to understand the expression and movement of mRNA. His lab developed methods to label RNA endogenously in cell lines and mice. He develops microscopy to observe and quantify single mRNAs in neuronal processes, and can follow the mRNA from transcription through nuclear export, translation and degradation.
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