Lily Jan's lab started their ion channel studies with molecular identification of the founding members of voltage-gated potassium channels (1987) and inwardly rectifying potassium channels (1993) and identification of TMEM16A and TMEM16B as calcium-activated chloride channels (2008). They now ask how these ion channels work, how the channel activity may be regulated at the level of channel property as well as channel density and localization, and how these channels contribute to cellular functions such as neuronal signaling.
Studies of Potassium Channel and Calcium-Activated Chloride Channel Function
We are studying potassium channels and calcium-activated chloride channels at different levels to ask how these channels work and what they do in the nervous system and other tissues.
Experimental approaches used in these studies include electrophysiological recording, biochemical analyses, and behavioral studies of mutant mice.