Joseph DeRisi employs a highly interdisciplinary approach, combining genomics, bioinformatics, biochemistry, and bioengineering to study parasitic and viral infectious diseases in a wide range of organisms.
Genomics and Infectious Disease
Our lab is dedicated to the study of infectious disease, including the causative agent of the most deadly form of human malaria, Plasmodium falciparum, and a wide range of viral pathogens. In particular, we use a variety of high-throughput genome-wide approaches, robotics, microfluidics, and bioinformatics to dissect the molecular physiology of the malaria parasite with respect to gene regulation, messenger RNA dynamics, and evolution of drug resistance. We are developing and applying similar strategies to examine the role of viruses in diseases of unknown etiology and the evolution of RNA viruses, including arenavirus, enterovirus, and many more. Throughout all of these projects, we pursue a highly interdisciplinary approach, consisting of expertise in parasitology, structural biology, genomics, bioinformatics, and virology, to develop new technologies and analysis approaches.