David Chan studies how the dynamic behaviors of mitochondria within a cell are controlled and how they affect cell and tissue physiology. These studies have implications for a broad range of human diseases, particularly neurological disorders.
Mitochondrial Quality Control
To maintain a highly functional mitochondrial population, cells must degrade defective mitochondria and also remove misfolded or aggregated mitochondrial proteins. We are studying the mechanism of these quality control processes, particularly mitophagy, the degradation of mitochondria via autophagy. Some forms of Parkinson's disease appear to result from a defect in these processes.