Anita Sil is using the fungal pathogen Histoplasma capsulatum, which inhabits both the soil and mammalian hosts, to understand how cells sense and respond to environmental signals such as temperature.
Regulation of Virulence and Cell Shape in Response to Temperature
We study transcription factors and signal transduction pathways required for a fungal intracellular pathogen to induce host-dependent cell shape changes and virulence gene expression.
Analysis of Genes Required for Virulence of a Fungal Intracellular Pathogen
We are identifying and characterizing virulence factors that are required for colonization of macrophages by a fungal pathogen.