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Our Scientists

Graham C. Walker, PhD
HHMI Professor / 2010–Present

Scientific Discipline

Molecular Biology

Host Institution

Massachusetts Institute of Technology

Current Position

Graham Walker is an American Cancer Society Professor in the Department of Biology at the Massachusetts Institute of Technology and an Affiliate Member of the Koch Institute for Integrative Cancer Research.

Current Research

An Education Group for Innovation in Undergraduate Biology Education

Graham Walker’s HHMI Education Group has allowed him to develop new tools and curricula for undergraduate biology while training young research scientists to become educators. The group’s members participate in a variety of teaching and educational projects, and play leadership roles in the continuing development, dissemination, and assessment of the student-friendly biology digital learning tools StarBiochem, StarGenetics, and StarCellBio.

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Biography

Graham Walker knew the Massachusetts Institute of Technology (MIT) was different. But he was still surprised when he arrived for a job interview in Cambridge in 1975 to discover that MIT was so serious about teaching undergraduates.…

Graham Walker knew the Massachusetts Institute of Technology (MIT) was different. But he was still surprised when he arrived for a job interview in Cambridge in 1975 to discover that MIT was so serious about teaching undergraduates. "Honestly, I was so excited at the end of that first day that I couldn't sleep," he remembers. Walker's love of teaching had not been much of a factor in his previous interviews, but at MIT he thought he could talk about his interests. "I felt like a lucky star had hit me on the head."

Walker started his teaching career by guiding MIT students through introductory lab courses and then switched to teaching advanced undergraduate research labs. "Lab courses were where I learned to teach because that's where I began to understand what students don't know about biology," Walker recalls. Now he leads a large introductory biology course once taught by Nobel Prize winner Salvador Luria. Along the way, Walker realized that something important was missing in science education: research. "I thought, 'Why don't I form an education group that's modeled after a lab research group?'" In 2002, with help from his HHMI professor funding, Walker hired three postdoctoral students to join a team focused on science education research. The group held regular lab meetings that were open to the MIT community, and soon dozens of faculty and graduate students were attending regularly. They talked about ways to make teaching easier and more accessible at all levels.

Those discussions resulted in a wave of projects, including a "teaching toolkit" for MIT teachers and graduate students, a curriculum for high school field trips that stressed the use of primary literature and evidence-based teaching methods, and a strategy for organizing and prioritizing the key ideas in a biology curriculum. The research group also brainstormed which biology concepts were important to modern science but hard to convey to students. One important topic was how to get students to understand the three-dimensional structure of proteins using "protein viewers," sophisticated molecular visualization engines that help scientists see how proteins are folded and how they work inside cells. Most protein viewer programs were too sophisticated for beginners but Walker believed that "playing with a protein" was exactly what new students needed to grasp how molecular biology works.

At first, Walker tried unleashing his first-year students on an advanced protein viewer by providing elaborate instructions. "That was a disaster," he recalls. Creating a simpler interface for an existing viewer proved to be too hard to implement. Then, one attendee at the education group meeting, Chuck Schubert of MIT's Office of Educational Innovation and Technology, suggested that they build their own protein viewer with a custom interface that was based on the principles of protein structure the students learned in introductory biology courses. That became StarBiochem. Released in 2006, StarBiochem is a powerful 3-D molecular viewer with a simple interface designed for educational purposes that has been accessed online more than 70,000 times by students and teachers from 144 countries. StarBiochem's success led to StarGenetics, an interactive simulator that models genetic crosses and a new program currently under development called StarCellBio, a cell and molecular biology experiment simulator.

With his second HHMI professor grant, Walker reestablished his science education group with two biology education researchers, Dr. Lourdes Alemán and Dr. Alison Brauneis. Among the projects his education group has been tackling is the design, development, implementation, and assessment of novel digital biology learning tools in both residential and online classrooms.

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Education

  • BSc, chemistry, Carleton University, Canada
  • PhD, chemistry and biochemistry, University of Illinois at Urbana-Champaign

Awards

  • American Cancer Society Research Professor
  • Environmental Mutagen Society Award
  • Charles Ross Scholar Award for Cancer Research
  • Doctor honoris causa, University of Guelph
  • Margaret MacVicar Faculty Fellow, Massachusetts Institute of Technology
  • Arthur C. Smith Award, Massachusetts Institute of Technology
  • John Simon Guggenheim Memorial Fellow
  • Rita Allen Foundation Career Development Award
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Memberships

  • National Academy of Sciences
  • American Association for the Advancement of Science, Fellow
  • American Academy of Arts and Sciences
  • American Academy of Microbiology
  • Genetics Society of America
  • American Society for Biochemistry and Molecular Biology
  • Environmental
  • Environmental Mutagenesis and Genomics Society
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