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Our Scientists

Carl Wu, PhD
Janelia Senior Fellow / 2012–Present

Scientific Discipline

Biochemistry, Molecular Biology

Host Institution

Janelia Research Campus

Current Position

Dr. Wu is a senior fellow at the Janelia Research Campus.

Current Research

Chromatin Structure and Function

Carl Wu's laboratory uses biochemical and optical approaches to study the structure and function of chromatin, in particular the mechanisms by which chromatin controls access to and expression of eukaryotic genomes.

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Biography

Carl Wu is a senior fellow at Janelia. Wu studies the molecular architecture of chromosomes and the role of chromatin structure in gene transcription—areas that are central to understanding how genomic information is programmed for selective…

Carl Wu is a senior fellow at Janelia. Wu studies the molecular architecture of chromosomes and the role of chromatin structure in gene transcription—areas that are central to understanding how genomic information is programmed for selective expression in the development of the organism. Wu received his BS from St. Mary'’s College and his PhD in biology from Harvard University, where he began his study of chromatin organization under Sarah Elgin. While a Junior Fellow at Harvard under Wally Gilbert, Wu found that the chromatin of gene promoters is remodeled as DNase I hypersensitive sites. From Harvard, Wu moved to the National Cancer Institute where he investigated biochemical mechanisms of chromatin remodeling for three decades and served as Chief of the Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research. At Janelia, Wu is extending his work in new directions, developing fresh analytical methods for the epigenome and imaging local chromatin dynamics and large-scale chromatin folding in live cells.

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Education

  • BS, St. Mary's College of California
  • PhD, biology, Harvard University

Awards

  • ASBMB/Schering-Plough Research Institute Award, American Society for Biochemistry and Molecular Biology

Memberships

  • Institute of Medicine of the National Academies
  • European Molecular Biology Organization
  • National Academy of Sciences
  • Academia Sinica
  • American Academy of Arts and Sciences
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