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Postdoctoral Research Fellowships Awarded

Postdoctoral Research Fellowships Awarded

Summary

HHMI selects young physicians to receive support to train as physician-scientists.

Thirty-seven young physicians have been selected as fellows by the Howard Hughes Medical Institute to spend the next three years studying the role of angiogenesis in cancer, possibilities for stem-cell-derived immunotherapy, molecular mechanisms of axonal sprouting after stroke, and other subjects at the frontier of biomedical research.

The physician postdoctoral fellows will receive training for careers as physician-scientists, experts who combine basic research skills with clinical experience. This combination gives them a unique understanding of diseases and helps them think in fresh ways of possible new treatments and cures.

The fellows are the latest in a highly competitive HHMI program that supports physicians in obtaining research training in the study of basic biological processes and disease mechanisms, at leading laboratories. All have completed at least two years of clinical training since graduating from medical school.

"These outstanding young physician-scientists are committed to advancing our knowledge of basic biological processes and disease mechanisms, at a time of unparalleled opportunity in medical research," said HHMI President Purnell W. Choppin, M.D. "They have selected superb mentors with whom to work as they explore the frontiers of biomedical science in such diverse areas as signaling systems, ion channels, genetic control of development, cancer pathogenesis, and malaria vaccines."

In this ninth year of the Postdoctoral Research Fellowships for Physicians program, the new fellows include 5 women and 32 men who will be working with research mentors at 26 universities, research institutions, and hospitals, including 8 HHMI laboratories. The three-year fellowships provide annually a stipend of $40,000 to $60,000, a research allowance of $16,000, and an institutional allowance of $13,000.

This year's group of awardees includes 33 physicians from the United States, two from Germany, and one each from Israel and Sudan. More than 90 physicians are now being supported under the fellowship program, at an annual cost of about $6 million.

"Molecular medicine is a reality as we approach the new millennium," said Joseph G. Perpich, M.D., J.D., HHMI's vice president for grants and special programs. "We have learned so much about the genetics and molecular biology of life, and how it goes awry. Studies of oncogenes, growth factors, and receptors, for example, point the way to new treatment for cancer, diabetes, and neurologic disorders. In the years ahead the fellows' work will cross the boundaries from basic to disease-oriented to patient-oriented research, resulting in exciting new approaches--for patients and populations--to the prevention, diagnosis, and treatment of disease."

The HHMI program differs from similar postdoctoral opportunities because it offers research support only to physicians who have had clinical experience since receiving their medical degrees. It complements other HHMI grant initiatives that support research training of medical and predoctoral students, research resources at U.S. medical schools, and the research of scientists outside the United States. HHMI has the nation's largest private program to improve science education.



HHMI Office of Grants and Special Programs
Postdoctoral Research Fellowships for Physicians 1998 Fellows


Cell and Developmental Biology


Gerard Conrad Blobe, M.D., Ph.D. , in the laboratory of Harvey F. Lodish, Ph.D., at Whitehead Institute for Biomedical Research, Department of Biology. His project is "Characterization of the TGFâ signaling pathway."

Edward Fung Chan, M.D. , in the laboratory of Elaine V. Fuchs, Ph.D., at Howard Hughes Medical Institute and the University of Chicago, Department of Cell Biology. His project is "The role of Wnt pathway signaling in hair follicle biology and skin cancer."

John Vincent Frangioni, M.D., Ph.D. , in the laboratories of Lewis C. Cantley, Ph.D., at Beth Israel Deaconess Medical Center, Department of Medicine, and Marc R. Montminy, M.D., Ph.D., at Joslin Diabetes Center, Research Department. His project is "Sub-nuclear targeting and functioning of the cAMP-regulated histone acetyltransferases."

Andrew Li-jen Kung, M.D., Ph.D. , in the laboratory of David Morse Livingston, M.D., at Dana- Farber Cancer Institute, Department of Cancer Biology. His project is "Characterization of the interaction of hypoxia-inducible factor 1 with p300/CBP as an effector of hypoxia-dependent gene expression and as a potential target of a new anti-tumor therapeutic strategy."

Calvin Jay Kuo, M.D., Ph.D. , in the laboratory of Judah Folkman, M.D., at Children's Hospital (Boston), Department of Surgery. His project is "Isolation and molecular cloning of a receptor for the angiogenesis inhibitor endostatin."

Paul T. Nghiem, M.D., Ph.D. , in the laboratory of Stuart L. Schreiber, Ph.D., at Howard Hughes Medical Institute and Harvard University, Department of Chemistry. His project is "PIK-related kinases in the response to DNA damage by UV."

Matthew Hebden Porteus, M.D., Ph.D. , in the laboratory of David Baltimore, Ph.D., at California Institute of Technology, Division of Biology. His project is "Characterization of factors that regulate homologous recombination."

Charles M. Roberts, M.D., Ph.D. , in the laboratory of Stuart H. Orkin, M.D., at Howard Hughes Medical Institute and Children's Hospital (Boston), Department of Medicine. His project is "Analysis of the function of the SCL oncogene: characterization of its role in the initiation of hematopoiesis and angiogenesis and evaluation of their developmental relationship."

Norman Edward Sharpless, M.D. , in the laboratories of Ronald A. DePinho, M.D., at Dana-Farber Cancer Institute, Department of Adult Oncology, and Anil K. Rustgi, M.D., at the University of Pennsylvania, Department of Gastroenterology. His project is "Transcriptional mechanisms in squamous epithelia."

 

Genetics and Molecular Biology


Yair Anikster, M.D. , in the laboratories of William Alan Gahl, M.D., Ph.D., at the National Institutes of Health, National Institute of Child Health and Human Development, and Eric D. Green, M.D., National Human Genome Research Institute. His project is "Molecular and cell biological studies of cystinosis, a prototypic disorder for determining the synthesis, targeting and processing of functional integral lysosomal membrane proteins."

Edgar Arnold Buttner, M.D., Ph.D. , in the laboratory of H. Robert Horvitz, Ph.D., at Howard Hughes Medical Institute and Massachusetts Institute of Technology, Department of Biology. His project is "Functional genomics of C. elegans used to study disease."

Mel B. Feany, M.D., Ph.D. , in the laboratories of Welcome W. Bender, Ph.D., at Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, and James F. Gusella, Ph.D., at Massachusetts General Hospital, Molecular Neurogenetics Unit. Her project is "Genetic model of neurodegeneration."

Michael John Gambello, M.D., Ph.D. , in the laboratory of Anthony Wynshaw-Boris, M.D., Ph.D., at National Institutes of Health, National Human Genome Research Institute. His project is "Segmental aneusomy syndromes: modeling of Miller-Dieker lissencephaly syndrome in the mouse."

William Chun Hahn, M.D., Ph.D. , in the laboratory of Robert A. Weinberg, Ph.D., at Whitehead Institute for Biomedical Research, Department of Biology. His project is "Regulation and function of the telomerase catalytic subunit."

John Louis Hartman, M.D. , in the laboratories of Leland H. Hartwell, M.D., at Fred Hutchinson Cancer Research Center, and Maynard V. Olson, Ph.D., at University of Washington, Department of Medicine. His project is "Genetic analysis of naturally selected polymorphic alleles of the pheromone response pathway in outbred strains of S. cerevisiae: fine-tuning or robustness of biochemical networks?"

Joel Naom Hirschhorn, M.D., Ph.D. , in the laboratory of Eric S. Lander, Ph.D., at Whitehead Institute for Biomedical Research, Department of Biology. His project is "Genetic analysis of bone density in inbred strains of mice."

Beatrice B. Jegalian, M.D., Ph.D. , in the laboratory of Leonard P. Guarante, Ph.D., at Massachusetts Institute of Technology, Department of Biology. Her project is "Genetic determinants of lifespan in yeast and mammalian stem cells."

Hanlee P. Ji, M.D. , in the laboratory of Mary-Claire King, Ph.D., at the University of Washington, Department of Medical Genetics. His project is "Characterization of PTEN as a target of defective mismatch repair related mutations."

Frederick Bradley Johnson, M.D., Ph.D. , in the laboratory of Leonard P. Guarante, Ph.D., at Massachusetts Institute of Technology, Department of Biology. His project is "Biochemical and functional characterization of the Werner's syndrome protein and investigation of the role of ribosomal DNA metabolism in senescence." *

Jae Keith Joung, M.D., Ph.D. , in the laboratory of Carl O. Pabo, Ph.D., at Howard Hughes Medical Institute and Massachusetts Institute of Technology, Department of Biology. His project is "General strategies for drug-regulated control of gene expression."

James Edwin Sligh, M.D., Ph.D. , in the laboratory of Douglas C. Wallace, Ph.D., at Emory University School of Medicine, Center for Molecular Medicine. His project is "Animal models of human mitochondrial disease."

David Juri Sulciner, M.D. , in the laboratory of Shaun R. Coughlin, M.D., Ph.D., at the University of California-San Francisco, Cardiovascular Research Institute. His project is "Identifying and characterizing a platelet specific chaperone protein for the thrombin receptor protease-activated receptor 3."

 

Immunology and Microbiology


Dirk Hans Busch, M.D. , in the laboratories of Eric G. Pamer, M.D., at Yale University School of Medicine, Section of Infectious Diseases, and Charles A. Janeway Jr., M.D., at Howard Hughes Medical Institute and Yale University, Department of Immunobiology. His project is "Generation and maintenance of epitope-specific memory T cell populations following bacterial infection."

Bettina Carolyn Fries, M.D. , in the laboratory of Arturo Casadevall, M.D., Ph.D., at Albert Einstein College of Medicine, Department of Medicine. Her project is "Molecular basis of phenotypic switching in 24067 mutant."

Barbara Irena Kazmierczak, M.D., Ph.D. , in the laboratories of Jeanne Netter Engel, M.D., Ph.D., at the University of California-San Francisco, Department of Medicine, and Keith E. Mostov, M.D., Ph.D., Department of Anatomy. Her project is "Epithelial cell invasion and injury by Pseudomonas aeruginosa."

Oliver Till Keppler, M.D. , in the laboratory of Mark Alan Goldsmith, M.D., Ph.D., at the J. David Gladstone Institutes, Gladstone Institute of Virology and Immunology. His project is "Interaction of HIV-1 envelope glycoproteins with specific cell surface receptors as a pathogenetic factor in AIDS."

Wes Lee, M.D., Ph.D. , in the laboratory of Irving L Weissman, M.D., at Stanford University School of Medicine, Department of Pathology. His project is "Stem cell-derived immunotherapy."

Michael A. Panzara, M.D. , in the laboratory of Michael B. Brenner, M.D., at Brigham and Women's Hospital, Department of Medicine. His project is "Antigen presentation by CD1."

Ali Awad Elkarim Sultan, M.B., B.S., Ph.D. , in the laboratories of Victor Nussenzweig, M.D., Ph.D., at New York University Medical Center, Department of Pathology, and Ruth S. Nussenzweig, M.D., Ph.D., Department of Medical and Molecular Parasitology. His project is "The A-domain of TRAP: a target for improving the efficacy of preerythrocytic malaria vaccines."

 

Neuroscience and Physiology


S. Thomas Carmichael, M.D., Ph.D. , in the laboratory of Marie-Francoise Chesselet, M.D., Ph.D., at the University of California-Los Angeles, Department of Neurology. His project is "Studies of the molecular mechanisms and cellular cues for axonal sprouting after focal stroke."

William T. Dauer, M.D. , in the laboratory of Rene Hen, Ph.D., at Columbia University College of Physicians and Surgeons, Department of Pharmacology. His project is "The generation and characterization of an animal model of DYT1 dystonia."

Andrew Paul Lieberman, M.D., Ph.D. , in the laboratory of Kenneth H. Fischbeck, M.D., at the National Institutes of Health, National Institute of Neurological Disorders and Stroke. His project is "Identification of androgen responsive genes in motor neurons."

Joseph Andrew Mindell, M.D., Ph.D. , in the laboratory of Chris Miller, Ph.D., at Howard Hughes Medical Institute and Brandeis University, Department of Biochemistry. His project is "Single- channel analysis and protein biochemistry of epithelial CIC-type chloride channels."

Vinod Misra, M.D., Ph.D. , in the laboratory of David E. Draper, Ph.D., at Johns Hopkins University, Department of Chemistry. His project is "On the role of metal ions in the stability of RNA."

Andrew Stewart Plump, M.D., Ph.D. , in the laboratory of Marc Tessier-Lavigne, Ph.D., at Howard Hughes Medical Institute and University of California-San Francisco, Department of Anatomy. His project is "Axon targeting: guidance at the midline."

Neil Alan Shneider, M.D., Ph.D. , in the laboratory of Thomas M. Jessell, Ph.D., at Howard Hughes Medical Institute and Columbia University, Department of Biochemistry and Molecular Biophysics. His project is "The genetic control of motor neuron identity."

 

Structural Biology and Biochemistry


Paula Goodman Fraenkel, M.D. , in the laboratory of Bruce Furie, M.D., at Beth Israel Deaconess Medical Center, Department of Medicine. Her project is "Vitamin-K dependent carboxylase recognition: identification of novel substrates."

 

*Award deferred from 1997