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October 11, 2007
The 2007 HHMI Patient-Oriented Researchers

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Vivian Cheung, M.D.

Vivian Cheung, M.D.
University of Pennsylvania School of Medicine
Philadelphia, PA

Vivian Cheung wants to create a genetic test to predict patients’ individual responses to the most commonly prescribed therapeutics. Moresmall arrow
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Arul M. Chinnaiyan, M.D., Ph.D.

Arul M. Chinnaiyan, M.D., Ph.D.
University of Michigan Medical School
Ann Arbor, MI

Arul Chinnaiyan is searching for chromosomal abnormalities that drive the formation of solid tumors, with the ultimate goal of improving the early diagnosis and therapy of common cancers. Moresmall arrow
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George Daley, M.D., Ph.D.

George Daley, M.D., Ph.D.
Children's Hospital Boston
Boston, MA

Through his studies of hematopoietic stem cells, George Daley is working toward improving drug and transplantation therapies for patients with bone marrow disease. Moresmall arrow
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Elizabeth Carson Engle, M.D.

Elizabeth C. Engle, M.D.
Children's Hospital Boston
Boston, MA

Elizabeth Engle is studying how errors in the growth and development of motor neurons can create complex eye-movement disorders. Moresmall arrow
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Erol Fikrig, M.D.

Erol Fikrig, M.D.
Yale University School of Medicine
New Haven, CT

Erol Fikrig is studying the relationship between pathogens, the vectors that carry them, and the hosts they infect, and looking for ways to interrupt those relationships to prevent or treat disease. Moresmall arrow
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Joseph G. Gleeson, M.D.

Joseph G. Gleeson, M.D.
University of California, San Diego School of Medicine
La Jolla, CA

Through his interactions with patients in the United States and the Middle East, Joseph Gleeson is working to understand the factors the brain needs to develop properly and the genetic mutations that can interfere with brain development. Moresmall arrow
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Daniel Haber, M.D., Ph.D.

Daniel Haber, M.D., Ph.D.
Massachusetts General Hospital
Boston, MA

Daniel Haber is investigating gene mutations that influence cancers' susceptibility to molecularly targeted cancer therapies as well as the genetics of the pediatric kidney cancer Wilms' tumor. Moresmall arrow
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Friedhelm Hildebrandt M.D.

Friedhelm Hildebrandt, M.D.
University of Michigan Medical School
Ann Arbor, MI

Friedhelm Hildebrandt is searching for genes responsible for childhood kidney diseases, enlisting the aid of thousands of patients worldwide. Moresmall arrow
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S. Ananth Karumanchi, M.D.

S. Ananth Karumanchi, M.D.
Beth Israel Deaconess Medical Center
Boston, MA

S. Ananth Karumanchi is studying the molecular defects that lead to preeclampsia and using this knowledge to find ways to prevent and treat the disease. Moresmall arrow
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Beth Cindy Levine, M.D.

Beth C. Levine, M.D.
University of Texas Southwestern Medical School at Dallas
Dallas, TX

Beth Levine is investigating the role of autophagy in cancer, infectious diseases, and autoimmune diseases to determine whether the process might be targeted for disease treatment. Moresmall arrow
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Christopher Vine Plowe, M.D.

Christopher V. Plowe, M.D.
University of Maryland Medical School
Baltimore, MD

Christopher Plowe studies the molecular evolution of malaria and the pathogen's response to vaccines and drug treatment, using his findings to extend the useful life of antimalarial drugs to treat patients in Africa and to develop malaria vaccines. Moresmall arrow
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Kerry J. Ressler, M.D., Ph.D.

Kerry J. Ressler, M.D., Ph.D.
Emory University School of Medicine
Atlanta, GA

Kerry Ressler is using new knowledge about the molecular neurobiology of emotional learning to understand and treat fear and stress-related disorders in human patients. Moresmall arrow
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David Henry Rowitch, M.D., Ph.D.

David H. Rowitch, M.D., Ph.D.
University of California, San Francisco School of Medicine
San Francisco, CA

David Rowitch is working to understand how problems that arise during development, particularly among the glial cells that support neurons in the brain, can lead to cerebral palsy. Moresmall arrow
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Charles Sawyers, M.D.

Charles L. Sawyers, M.D.
Memorial Sloan-Kettering Cancer Center
New York, NY

Charles Sawyers is investigating the signaling pathways that drive the growth of cancer cells, with an eye toward designing new treatment options for patients with chronic myeloid leukemia, prostate cancer, and glioblastoma. Moresmall arrow
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Andrey Shaw, M.D.

Andrey Shaw, M.D.
Washington University School of Medicine in St. Louis
St. Louis, MO

Andrey Shaw is searching for genetic mutations that cause chronic kidney disease by interfering with the kidney’s ability to filter proteins from the blood. Moresmall arrow

   

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